Magnetic properties of Zn-substituted MnFe<sub>2</sub>O<sub>4</sub> nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells

Beji, Z.; Hanini, Amel; Smiri, Leila Samia; Gavard, Julie; Kacem, Kamel; Villain, F.; Grenèche, Jean‐Marc; Chau, François; Ammar, Souad

doi:10.1021/cm1001708

Cited by 108 publications

(66 citation statements)

References 59 publications

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“…Cell viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)diphenyltetrazolium bromide (MTT) method according to manufacturer's instructions (SigmaAldrich) as previously reported. 18 Cell viability was calculated as a ratio between treated (sample) and untreated (control).…”

Section: Western Blotmentioning

confidence: 99%

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Evaluation of iron oxide nanoparticle biocompatibility

Hanini¹,

Schmitt²,

Kacem³

et al. 2011

IJN

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Nanotechnology is an exciting field of investigation for the development of new treatments for many human diseases. However, it is necessary to assess the biocompatibility of nanoparticles in vitro and in vivo before considering clinical applications. Our characterization of polyol-produced maghemite γ-Fe 2 O 3 nanoparticles showed high structural quality. The particles showed a homogeneous spherical size around 10 nm and could form aggregates depending on the dispersion conditions. Such nanoparticles were efficiently taken up in vitro by human endothelial cells, which represent the first biological barrier to nanoparticles in vivo. However, γ-Fe 2 O 3 can cause cell death within 24 hours of exposure, most likely through oxidative stress. Further in vivo exploration suggests that although γ-Fe 2 O 3 nanoparticles are rapidly cleared through the urine, they can lead to toxicity in the liver, kidneys and lungs, while the brain and heart remain unaffected. In conclusion, γ-Fe 2 O 3 could exhibit harmful properties and therefore surface coating, cellular targeting, and local exposure should be considered before developing clinical applications.

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Section: Western Blotmentioning

confidence: 99%

“…These results are in agreement with the average crystal size inferred from X-ray diffraction line broadening using the Scherrer formula. 16,18 There is no evidence of physical defects such as dislocation and stacking, or of amorphous regions at the surface, suggesting high crystalline quality in single particles.…”

Section: Iron Oxide Np Characterizationmentioning

confidence: 99%

Evaluation of iron oxide nanoparticle biocompatibility

Hanini¹,

Schmitt²,

Kacem³

et al. 2011

IJN

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“…A metal dopant of ferrite nanoparticles has been pursued to achieve high and tunable nanomagnetism (Beji et al, 2010;Hochepied and Pileni, 2000;Sun et al, 2004). Jang et al (2009) , and Fe…”

Section: Controlled Properties Of Nanoparticlesmentioning

confidence: 99%

Controlled Magnetic Properties of Iron Oxide-Based Nanoparticles for Smart Therapy

Kim

2016

KONA

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Magnetic nanoparticles provide a unique nanosystem for various smart therapy applications because of their biocompatibility, their nanostructures which can be prepared controllably to match with the interest of study and, specifically, their responses to an external magnetic field. Interests in utilizing magnetic nanoparticles for biomedical treatments originate from their external controllability of transportation and movement inside biological objects and magnetic heat generation which provide tremendous advantages for targeted drug delivery and controlled drug release as well as magnetic hyperthermia. Recent progress in synthesis and functionalization has led to the formation of various functional magnetic nanoparticles with controlled magnetic properties based on controlling their particle size, shape and composition. In this review, we focus on the synthesis, protection and functionalization of iron oxide-based magnetic nanoparticles in order to control magnetic properties of nanostructured systems. We also highlight the recent advances in the development of multifunctional therapeutic nanosystems combining magnetic nanoparticles and drugs as well as their superior efficacy in biomedical treatments with smart performance by including therapy and modulated drug delivery and release through magnetic heating.

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“…[21][22][23][24][25] Three nanoparticle samples were evaluated at concentrations within the range widely used in clinic 26,27 and experimental studies. 16,28 Some nanoparticles were surface-coated with citrate (the coating agent already used for magnetic resonance image -see Sosnovik et al 29 ) or tripolyphosphate.…”

Section: Introductionmentioning

confidence: 99%

Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects

Nunes¹,

Ramalho²,

Souza³

et al. 2014

IJN

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Magnetic nanoparticles (MNPs) have been used for various biomedical applications. Importantly, manganese ferrite-based nanoparticles have useful magnetic resonance imaging characteristics and potential for hyperthermia treatment, but their effects in the cardiovascular system are poorly reported. Thus, the objectives of this study were to determine the cardiovascular effects of three different types of manganese ferrite-based magnetic nanoparticles: citrate-coated (CiMNPs); tripolyphosphate-coated (PhMNPs); and bare magnetic nanoparticles (BaMNPs). The samples were characterized by vibrating sample magnetometer, X-ray diffraction, dynamic light scattering, and transmission electron microscopy. The direct effects of the MNPs on cardiac contractility were evaluated in isolated perfused rat hearts. The CiMNPs, but not PhMNPs and BaMNPs, induced a transient decrease in the left ventricular end-systolic pressure. The PhMNPs and BaMNPs, but not CiMNPs, induced an increase in left ventricular end-diastolic pressure, which resulted in a decrease in a left ventricular end developed pressure. Indeed, PhMNPs and BaMNPs also caused a decrease in the maximal rate of left ventricular pressure rise (+dP/dt) and maximal rate of left ventricular pressure decline (−dP/dt). The three MNPs studied induced an increase in the perfusion pressure of isolated hearts. BaMNPs, but not PhMNPs or CiMNPs, induced a slight vasorelaxant effect in the isolated aortic rings. None of the MNPs were able to change heart rate or arterial blood pressure in conscious rats. In summary, although the MNPs were able to induce effects ex vivo, no significant changes were observed in vivo. Thus, given the proper dosages, these MNPs should be considered for possible therapeutic applications.

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Magnetic properties of Zn-substituted MnFe₂O₄ nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells

Cited by 108 publications

References 59 publications

Evaluation of iron oxide nanoparticle biocompatibility

Evaluation of iron oxide nanoparticle biocompatibility

Controlled Magnetic Properties of Iron Oxide-Based Nanoparticles for Smart Therapy

Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects

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Magnetic properties of Zn-substituted MnFe2O4 nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells

Cited by 108 publications

References 59 publications

Evaluation of iron oxide nanoparticle biocompatibility

Evaluation of iron oxide nanoparticle biocompatibility

Controlled Magnetic Properties of Iron Oxide-Based Nanoparticles for Smart Therapy

Manganese ferrite-based nanoparticles induce ex vivo, but not in vivo, cardiovascular effects

Contact Info

Product

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Magnetic properties of Zn-substituted MnFe₂O₄ nanoparticles synthesized in polyol as potential heating agents for hyperthermia. Evaluation of their toxicity on Endothelial cells