Magnetic resonance and spectroscopic imaging in prenatal alcohol-exposed children: Preliminary findings in the caudate nucleus

Cortese, Bernadette M.; Moore, Gregory J.; Bailey, Beth A.; Jacobson, Sandra W.; Delaney‐Black, Virginia; Hannigan, John H.

doi:10.1016/j.ntt.2006.08.002

Cited by 77 publications

(95 citation statements)

References 59 publications

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“…Currently, there are only three pertinent studies [28][29][30] , shown in Table 5. All three studies differ regarding voxel localization, which makes it more difficult to compare results.…”

Section: Methodsmentioning

confidence: 99%

“…Cortese et al 29 studied the caudate nucleus through 1h-Mrs in seven children with FAs, two children with alcohol fetal effects, and four control children, with an age range of 9-12 years and including both genders. They found an elevated NAA/Cr ratio in left and right caudate nuclei (p=0.04 and 0.03, respectively) in FAs affected children compared with controls.…”

Section: Methodsmentioning

confidence: 99%

“…There was also an increase in NAA peak (p=0.01) in right caudate nucleus and in NAA/Cr ratio (p=0.03) in left caudate nucleus in children with alcohol fetal effects versus controls. The authors suggest that, although neuronal dysfunction is traditionally associated with a decrease in NAA absolute concentration, the increase in NAA could also reflect functional abnormalities and cognitive deficits 29 .…”

Section: Methodsmentioning

confidence: 99%

“…Among the three previous studies, two of them used a multivoxel approach 29,30 , aiming to assess several components of a lesion in a specific time and, therefore, to show the metabolic abnormality extent 31 . In the present study, a decision was made to sequentially use single voxels in different regions.…”

Section: Methodsmentioning

confidence: 99%

“…1h-Mrs may also be able to assess integrity of neuronal and glial markers 29 . Nevertheless, the increased 1h-Mrs sensitivity is counteracted by its decreased specificity, as similar changes in cerebral metabolites may be found in various central nervous system disorders.…”

Section: Methodsmentioning

confidence: 99%

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Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Gonçalves

Vasconcelos

Faleiros

et al. 2009

Arq. Neuro-Psiquiatr.

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-Objective: To analyze the metabolic constitution of brain areas through proton magnetic resonance spectroscopy in children affected with fetal alcohol spectrum disorder compared with normal children. Method: The sample of this case-control study included eight boys with epidemiologic history of in utero exposure to alcohol (median age 13.6±3.8 years) who were diagnosed with fetal alcohol spectrum disorder, and eight controls (median age 12.1±3,4 years). An 8 cm 3 single voxel approach was used, with echo time 30 ms, repetition time 1500 ms, and 128 acquisitions in a 1.5T scanner, and four brain areas were analyzed: anterior cingulate, left frontal lobe, left striatum, and left cerebellar hemisphere. Peaks and ratios of metabolites N-acetylaspartate, choline, creatine, and myo-inositol were measured. Results: Children with fetal alcohol spectrum disorder showed a decrease in choline/creatine ratio (p=0.020) in left striatum and an increase in myo-inositol/creatine ratio (p=0.048) in left cerebellum compared with controls. There was no statistically significant difference in all peaks and ratios from the anterior cingulate and frontal lobe between the two groups. Conclusion: This study found evidence that the left striatum and left cerebellum are affected by intrauterine exposure to alcohol. Additional studies with larger samples are necessary to expand our knowledge of the effects of fetal exposure to alcohol.Key words: fetal alcohol syndrome, alcohol-induced disorders of the nervous system, ethanol, fetal development, magnetic resonance spectroscopy. espectroscopia por ressonância magnética de prótons em crianças com transtornos do espectro alcoólico fetal resumo -Objetivo: Analisar a composição metabólica de áreas encefálicas através da espectroscopia de prótons por ressonância magnética em crianças com transtornos do espectro alcoólico fetal e crianças normais. Método: A amostra deste estudo de casos-controles incluiu 8 meninos com história epidemiológica de exposição fetal ao álcool (idade mediana 13,6±3,8 anos), diagnosticados com transtorno do espectro alcoólico fetal, e 8 controles (idade mediana 12,1±3,4 anos). Utilizou-se voxel único de 8 cm³, tempo de eco 30 ms, tempo de repetição 1.500 ms, 128 aquisições, em scanner de 1,5T para as seguintes áreas: cíngulo anterior, lobo frontal esquerdo, estriado esquerdo e hemisfério cerebelar esquerdo. estudaram-se os picos e as razões dos metabólitos N-acetilaspartato, colina, creatina e o mio-inositol. Resultados: As crianças acometidas apresentaram diminuição da razão colina/creatina (p=0,020) no estriado esquerdo, e aumento da razão mio-inositol/creatina (p=0,048) no cerebelo esquerdo. Não houve diferença estatisticamente significativa nos valores encontrados no cíngulo anterior e lobo frontal entre os dois grupos. Conclusão: este estudo encontrou evidências de que o estriado e o cerebelo esquerdos são acometidos pela exposição intra-uterina ao álcool. estudos adicionais com amostras maiores são essenciais para expandir nosso conhecimento dos efeitos d...

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“…Currently, there are only three pertinent studies [28][29][30] , shown in Table 5. All three studies differ regarding voxel localization, which makes it more difficult to compare results.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Gonçalves

Vasconcelos

Faleiros

et al. 2009

Arq. Neuro-Psiquiatr.

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Differential neuroimaging indices in prefrontal white matter in prenatal alcohol‐associated ADHD versus idiopathic ADHD

O’Neill

O’Connor

Yee

et al. 2019

Birth Defects Research

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Background: Attention deficit-hyperactivity disorder (ADHD) is common in fetal alcohol spectrum disorders (FASD) but also in patients without prenatal alcohol exposure (PAE). Many patients diagnosed with idiopathic ADHD may actually have ADHD and covert PAE, a treatment-relevant distinction. Methods: We compared proton magnetic resonance spectroscopic imaging (MRSI; N = 44) and diffusion tensor imaging (DTI; N = 46) of the anterior corona radiata (ACR)-a key fiber tract in models of ADHD-at 1.5 T in children with ADHD with PAE (ADHD+PAE), children with ADHD without PAE (ADHD−PAE), children without ADHD with PAE (non-ADHD+PAE), and children with neither ADHD nor PAE (non-ADHD−PAE, i.e., typically developing controls). Levels of choline-compounds (Cho) were the main MRSI endpoint, given interest in dietary choline for FASD; the main DTI endpoint was fractional anisotropy (FA), as ACR FA may reflect ADHD-relevant executive control functions. Results: For ACR Cho, there was an ADHD-by-PAE interaction (p = 0.038) whereby ACR Cho was 26.7% lower in ADHD+PAE than in ADHD−PAE children (p < 0.0005), but there was no significant ACR Cho difference between non-ADHD+PAE and non-ADHD−PAE children. Voxelwise false-discovery rate (FDR)-corrected analysis of DTI revealed significantly (q ≤ 0.0101-0.05) lower FA in ACR for subjects with PAE (ADHD+PAE or non-ADHD+PAE) than for subjects without PAE (ADHD−PAE or non-ADHD−PAE). There was no significant effect of ADHD on FA. Thus, in overlapping samples, effects of PAE on Cho and FA were observed in the same white-matter tract. Conclusions: These findings point to tract focal, white-matter pathology possibly specific for ADHD+PAE subjects. Low Cho may derive from abnormal choline metabolism; low FA suggests suboptimal white-matter integrity in PAE. More advanced MRSI and DTI-and neurocognitive assessments-may better distinguish ADHD+PAE from ADHD−PAE, helping identify covert cases of FASD.

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Impact of fetal alcohol exposure on body systems: A systematic review

Caputo

Wood

Jabbour

2016

Birth Defects Research Pt C

142

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Evidence shows that the brain was the most severely impacted organ of the body systems discussed. However, prenatal alcohol exposure causes several abnormalities within the heart, kidney, liver, gastrointestinal tract, and the endocrine systems. In addition, preventative measures need to be taken by mothers during pregnancy. Birth Defects Research (Part C), 2016. © 2016 Wiley Periodicals, Inc. Birth Defects Research (Part C) 108:174-180, 2016. © 2016 Wiley Periodicals, Inc.

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Magnetic resonance and spectroscopic imaging in prenatal alcohol-exposed children: Preliminary findings in the caudate nucleus

Cited by 77 publications

References 59 publications

Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Proton magnetic resonance spectroscopy in children with fetal alcohol spectrum disorders

Differential neuroimaging indices in prefrontal white matter in prenatal alcohol‐associated ADHD versus idiopathic ADHD

Impact of fetal alcohol exposure on body systems: A systematic review

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