Magnetic resonance assessment of the cerebral alterations associated with obesity development

Lizarbe, Blanca; Campillo, Basilio Willem; Guadilla, Irene; López‐Larrubia, Pilar; Cerdán, Sebastián

doi:10.1177/0271678x20941263

Cited by 13 publications

(27 citation statements)

References 147 publications

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“…However, two experimental animal studies have found that increased hypothalamic mIns-concentration is correlated with obesity and appetite behavior 49,50 . Our ndings obtained between BMI and hypothalamic Glc-concentration differ with the systematic review of Lizarbe et al, which reported a high glycemic concentration in brain tissue of animal models with high-fat diet consumption and obesity by using MRS 51 . One possibility that could explain these differences is that our sample size did not include clinically obese subjects or metabolic syndrome.…”

Section: Discussioncontrasting

confidence: 99%

WITHDRAWN: Hypothalamic Myo-Inositol and Glucose concentrations, mood symptoms and fatigue in depression: a 3 Tesla chemical-shift-imaging in vivo proton magnetic resonance spectroscopy study

Pedraz-Petrozzi

Blecker

Sammer

2020

Preprint

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Background: Many studies have confirmed altered brain Myo-Inositol (mIns) and Glucose (Glc) concentrations in depression. Alterations in the mIns-concentrations may represent a glial dysfunction and are associated mostly with depression symptoms. In comparison, alterations in the Glc-concentrations could represent impaired glucose metabolism. Despite this information, studies that assess these metabolites in the hypothalamus are missing. Therefore, this study aims to investigate mIns- and Glc-concentrations in the hypothalamus of participants with depression concerning mood symptoms and fatigue.Methods: We performed an in vivo proton magnetic resonance spectroscopy – chemical shift imaging of the hypothalamus in 49 participants (25 with depression diagnosis or DE, 24 healthy controls or HC), evaluating mIns- and Glc-concentrations. Concerning information about symptoms, we recollected information on depression symptomatology (BDI-FSTOT) and fatigue (FIS-D). For statistical analysis, we run generalized linear models by using the Poisson regression model with count data.Results: The results showed reduced hypothalamic mIns-concentration for every DE participant with higher FIS-D and higher BDI-FSTOT values (OR = 0.022; p < 0.001; CI95 [0.004 to 0.09]). Besides, the results showed increased hypothalamic Glc-concentration for every participant of the DE group and with higher BDI-FSTOT values (OR = 4.827; p = 0.002; CI95 [1.826 to 13.749]).Conclusions: These results provide initial evidence of a glial dysfunction and impaired glucose metabolism in the hypothalamus associated with mood symptoms and fatigue. Future studies are needed to confirm these pathophysiologic mechanisms.

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Section: Discussioncontrasting

confidence: 99%

WITHDRAWN: Hypothalamic Myo-Inositol and Glucose concentrations, mood symptoms and fatigue in depression: a 3 Tesla chemical-shift-imaging in vivo proton magnetic resonance spectroscopy study

Pedraz-Petrozzi

Blecker

Sammer

2020

Preprint

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“…In this context, MRI methods have been recently reviewed to be helpful for the characterization of the physio-pathological processes in the brain associated with obesity development. 19 As a consequence of a potential reduction of CBF, we hypothesize further that HFD feeding leads to changes in behavior and TEL treatment can prevent these changes since there are studies which show that ARB have beneficial effects in Alzheimer’s disease. 20,21 Therefore, we used different tests that address memory and anxiety-like behavior.…”

Section: Introductionmentioning

confidence: 97%

Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior

Huber

Ogrodnik

Wenzel

et al. 2021

J Cereb Blood Flow Metab

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Angiotensin II receptor blockers (telmisartan) prevent rodents from diet-induced obesity and improve their metabolic status. Hyperglycemia and obesity are associated with reduced cerebral blood flow and neurovascular uncoupling which may lead to behavioral deficits. We wanted to know whether a treatment with telmisartan prevents these changes in obesity. We put young mice on high-fat diet and simultaneously treated them with telmisartan. At the end of treatment, we performed laser speckle imaging and magnetic resonance imaging to assess the effect on neurovascular coupling and cerebral blood flow. Different behavioral tests were used to investigate cognitive function. Mice developed diet-induced obesity and after 16, not 8 weeks of high-fat diet, however, the response to whisker pad stimulation was about 30% lower in obese compared to lean mice. Simultaneous telmisartan treatment increased the response again by 10% compared to obese mice. Moreover, telmisartan treatment normalized high-fat diet-induced reduction of cerebral blood flow and prevented a diet-induced anxiety-like behavior. In addition to that, telmisartan affects cellular senescence and string vessel formation in obesity. We conclude, that telmisartan protects against neurovascular unit impairments in a diet-induced obesity setting and may play a role in preventing obesity related cognitive deficits in Alzheimer’s disease.

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“… 1 , 5 With respect to the hypothalamus, no consistent structural hypothalamic abnormalities have been established in association with obesity in general, although its involvement in the functional networks of food intake and energy metabolism is beyond all doubt. 20 A multiparametric MRI study demonstrated a relation between BMI and higher proton diffusivity in the hypothalamus but also not with hypothalamic total volume. 21 On the contrary, in systemic diseases which are associated with substantial metabolic alterations, body weight loss due to hypermetabolism, and/or reduced food intake has been demonstrated to be associated with hypothalamic atrophy, for example, in neurodegenerative diseases like amyotrophic lateral sclerosis 13 or Huntington’s disease 22 and in anorexia nervosa.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, future studies will have to use correlational analyses with fluid hormonal markers like leptin, somatostatin, and hormones of androgen metabolism together with advanced structural and functional neuroimaging techniques which allow for more detailed differentiation of hypothalamic subunits and target the hypothalamic connectivity. 20 , 21 , 23 , 33 , 34 …”

Section: Discussionmentioning

confidence: 99%

Morphological alterations of the hypothalamus in idiopathic intracranial hypertension

Kassubek

Weinstock

Behler

et al. 2022

Therapeutic Advances in Chronic Disease

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Background: The pathophysiology of idiopathic intracranial hypertension (IIH), a condition characterized by raised intracranial pressure, is not well understood. Objectives: We hypothesized that the hypothalamus might exhibit alterations in patients with IIH, based on its established association with obesity and the potential role of hormonal and metabolic factors in IIH. Design: Retrospective single-center cohort study. Methods: Thirty-three individuals with IIH and 40 matched healthy individuals were studied, including levels of the hormones and proteins leptin, adiponectin, ghrelin, insulin, growth/differentiation factor 15 (GDF15), somatostatin, and melatonin. In vivo high-resolution T1-weighted magnetic resonance imaging (MRI) data were analyzed by quantification of hypothalamic volumes using a well-established segmentation method, separate for the anterior and the posterior hypothalamic subvolumes. An additional analysis was performed using age, gender, and BMI-matched subgroups of 20 IIH patients and 20 controls. Results: The analysis of laboratory values showed significantly increased insulin, leptin, and melatonin levels for IIH patients in comparison to controls, while adiponectin levels were decreased in IIH; however, only melatonin level differences could be confirmed in the analysis with BMI matching. There was no statistical difference in total hypothalamus volumes between IIH and controls, but the hypothalamic morphology was altered in IIH patients with a lower volume of the anterior part of the hypothalamus and a higher volume of the posterior part; these results were identical in the analysis of the BMI-matched groups. The correlation analyses between hormonal changes and hypothalamic morphology did not achieve significant results. Conclusion: In this exploratory study, morphological abnormalities of the hypothalamus were observed to be associated with the IIH complex, although the mechanism remains to be unraveled. These findings expand the metabolic phenotype of IIH, but further functional studies are necessary to corroborate these data.

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Magnetic resonance assessment of the cerebral alterations associated with obesity development

Cited by 13 publications

References 147 publications

WITHDRAWN: Hypothalamic Myo-Inositol and Glucose concentrations, mood symptoms and fatigue in depression: a 3 Tesla chemical-shift-imaging in vivo proton magnetic resonance spectroscopy study

WITHDRAWN: Hypothalamic Myo-Inositol and Glucose concentrations, mood symptoms and fatigue in depression: a 3 Tesla chemical-shift-imaging in vivo proton magnetic resonance spectroscopy study

Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior

Morphological alterations of the hypothalamus in idiopathic intracranial hypertension

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