Magnetic Resonance Characterization of Ischemic Tissue Metabolism

Cheung, J. T.; Wang, Xiaoying; Sun, Phillip Zhe

doi:10.2174/1874440001105010066

Cited by 6 publications

(5 citation statements)

References 142 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The substance is a product of anaerobic glycolysis metabolism, typically detectable in brain diseases under hypoxia conditions ( e.g. , stroke, encephalopathy) [ 69 , 70 ]. Finally, Taurine (Tau) : Tau is associated with two sets of spectral peaks at 3.25 ppm and 3.42 ppm [ 71 , 72 ].…”

Section: Technical Remarksmentioning

confidence: 99%

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

Zhang¹,

Song²,

Bartha³

et al. 2014

CAR

View full text Add to dashboard Cite

Alzheimer’s disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV 1H MRS). Although the often heralded diagnostic potential of MRS in AD largely remains unfulfilled, more recent use of high magnetic fields has led to significantly improved signal-to-noise ratios and spectral resolutions, thereby allowing clinical applications with increased measurement reliability. The present article provides a comprehensive review of SV 1H MRS studies on AD at high magnetic fields (3.0 Tesla and above). This review suggests that patterned regional differences and longitudinal alterations in several neurometabolites are associated with clinically established AD. Changes in multiple metabolites are identifiable even at early stages of AD development. By combining information of neurochemicals in different brain regions revealing either pathological or compensatory changes, high field MRS can be evaluated in AD diagnosis and in the detection of treatment effects. To achieve this, standardization of data acquisition and analytical approaches is needed.

show abstract

Section: Technical Remarksmentioning

confidence: 99%

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

Zhang¹,

Song²,

Bartha³

et al. 2014

CAR

View full text Add to dashboard Cite

show abstract

“…Recently we began studies to establish both the therapeutic effectiveness of different liposomal formulations of bovine CuZn-SOD on animal models of arthritis and IRI, as well as to test a new contrast agent for Magnetic Resonance Imaging (MRI) with high spatial resolution (magnetic resonance microscopy, MRM) (Corvo et al, 2015;Martins et al, 2014). MRM has been suggested as a promising technique for medical imaging not only to diagnose acute ischaemia but also to follow up the complex chain of events that follows an acute ischaemia (Cheung et al, 2011;Martins et al, 2014). MRM can be used on live animals and when used for imaging of fixed specimens has advantages over conventional microscopy because it is non-destructive, can be 3D, and is inherently digital (Driehuys et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy

Marcelino

Marinho

Campos

et al. 2017

European Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Liver ischaemia-reperfusion injury (IRI) may occur during hepatic surgery and is unavoidable in liver transplantation. Superoxide dismutase enzymosomes (SOD-enzymosomes), liposomes where SOD is at the liposomal surface expressing enzymatic activity in intact form without the need of liposomal disruption, were developed with the aim of having a better insight into its antioxidant therapeutic outcome in IRI. We also aimed at validating magnetic resonance microscopy (MRM) at 7T as a tool to follow IRI. SOD-enzymosomes were characterized and tested in a rat ischaemia-reperfusion model and the therapeutic outcome was compared with conventional long circulating SOD liposomes and free SOD using biochemical liver injury biomarkers, histology and MRM. MRM results correlated with those obtained using classical biochemical biomarkers of liver injury and liver histology. Moreover, MRM images suggested that the therapeutic efficacy of both SOD liposomal formulations used was related to prevention of peripheral biliary ductular damage and disrupted vascular architecture. Therefore, MRM at 7T is a useful technique to follow IRI. SOD-enzymosomes were more effective than conventional liposomes in reducing liver ischaemia-reperfusion injury and this may be due to a short therapeutic window.

show abstract

“…Stroke is a severe neurovascular disease caused by focal or global interruption of blood supply to the brain, leading to transient or permanent neuropsychiatric impairments [ 76 ]. During this process, ATP levels are reduced, triggering lactate accumulation and activating the inflammatory cascade response, resulting in post-ischemic brain tissue necrosis [ 77 , 78 ]. While autophagy may represent a critical route to cleaning damaged proteins or debris early in ischemic occurrence, excessive autophagy leads to substantial death [ 79 ].…”

Section: Treatment Of Neurological Disorders: Pten In Stem Cellsmentioning

confidence: 99%

Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review

Li,

Ma,

Hao

2024

Cell Death Dis

View full text Add to dashboard Cite

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) represents the initial tumor suppressor gene identified to possess phosphatase activity, governing various cellular processes including cell cycle regulation, migration, metabolic pathways, autophagy, oxidative stress response, and cellular senescence. Current evidence suggests that PTEN is critical for stem cell maintenance, self-renewal, migration, lineage commitment, and differentiation. Based on the latest available evidence, we provide a comprehensive overview of the mechanisms by which PTEN regulates activities of different stem cell populations and influences neurological disorders, encompassing autism, stroke, spinal cord injury, traumatic brain injury, Alzheimer’s disease and Parkinson’s disease. This review aims to elucidate the therapeutic impacts and mechanisms of PTEN in relation to neurogenesis or the stem cell niche across a range of neurological disorders, offering a foundation for innovative therapeutic approaches aimed at tissue repair and regeneration in neurological disorders.

show abstract

Magnetic Resonance Characterization of Ischemic Tissue Metabolism

Cited by 6 publications

References 142 publications

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

Therapeutic activity of superoxide dismutase-containing enzymosomes on rat liver ischaemia-reperfusion injury followed by magnetic resonance microscopy

Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review

Contact Info

Product

Resources

About