Magnetic Resonance Imaging and Pathological Analysis of a Pituicytoma

Hurley, Thomas R.; D’Angelo, Charles M.; Clasen, Raymond A.; Wilkinson, Steven B.; Passavoy, Robert D.

doi:10.1227/00006123-199408000-00021

Cited by 60 publications

(31 citation statements)

References 12 publications

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“…The most common tumors in this region are pituitary adenoma and granular cell tumors. 6) Pituicytomas show similar histological features to the normal neurohypophysis. 1) The immunohistochemical characteristics are of glial origin.…”

Section: Discussionmentioning

confidence: 97%

“…5,9) The magnetic resonance (MR) imaging and clinicopathological features of this unique tumor have recently been described, indicating distinctive differentiation from granular cell tumor, and pilocytic or ordinary fibrillary astrocytomas. 1,6) Nineteen cases have been reported with typical pathological findings and localization. 1,2,4,[6][7][8]11,12) We report two new cases of suprasellar pituicytomas showing no regrowth after partial removal, and discuss the clinical manifestations, indications for management, and role of adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

“…1,6) Nineteen cases have been reported with typical pathological findings and localization. 1,2,4,[6][7][8]11,12) We report two new cases of suprasellar pituicytomas showing no regrowth after partial removal, and discuss the clinical manifestations, indications for management, and role of adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

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Pituicytoma-Two Case Reports-

Nakasu

Saito

et al. 2006

Neurol. Med. Chir.(Tokyo)

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Pituicytoma is a rare tumor in the sellar or suprasellar region with distinct histological characteristics of glial neoplasm. A 42-year-old woman presented with a history of amenorrhea and vertigo, and a 62-year-old woman presented with mild headache. Both patients had mild hyperprolactinemia and one had mild anterior pituitary dysfunction. They underwent transcranial partial resection of a suprasellar tumor. The tumors were characterized by storiform pattern of elongated cells immunoreactive for S-100 protein and glial fibrillary acidic protein. Ultrastructural study showed abundant cytoplasmic intermediate filaments and tumor/blood vessel basal lamina, but no desmosomes between tumor cells. The residual tumors showed no changes in size without adjuvant therapy at 56 and 18 months after surgery. Pituicytoma is a glial neoplasm of adults with low proliferative activity. Patients often present with visual symptoms or anterior pituitary dysfunction. Symptoms and signs of neurohypophysis are rare. Neuroimaging reveals an intra-or suprasellar mass with non-specific features. The prognosis and role of adjuvant therapy remain unclear for this discrete noninfiltrative glioma.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Pituicytoma-Two Case Reports-

Nakasu

Saito

et al. 2006

Neurol. Med. Chir.(Tokyo)

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“…In the present study, cases 1 and 3 exhibited solid cystic tumors. The differential diagnoses had included pituitary adenoma, meningioma, craniopharyngioma, hemangiopericytoma, pilocytic astrocytoma, granulocyte tumor, ganglioglioma, germinoma, hamartoma and metastatic tumors (6,27).…”

Section: Discussionmentioning

confidence: 99%

Pituicytoma: A report of three cases and literature review

Yang

Liu

et al. 2016

Oncology Letters

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Abstract. Pituicytoma is a rare tumor of the sellar and suprasellar regions, arising from the pituicytes, which are specialized glial cells in the neurohypophysis and infundibulum. Due to its rarity, ambiguity persists over the diagnosis, management and prognosis of pituicytoma. The current study presents a case series of three patients, each with a histopathological diagnosis of pituicytoma. A summary of the clinical manifestations, radiological characteristics, histopathological features, treatment strategies and prognoses are presented. In addition, 78 cases of pituicytoma, identified in a search of the published literature in Pubmed, are profiled. Pituicytoma typically presents with dysfunction of the optic nerve and pituitary. The radiological characteristics are nonspecific; diagnosis is typically made on the basis of histopathological results. The tumor is slow growing and benign and is amenable to surgical treatment by gross total resection; subsequent tumor recurrence is rare. A definitive assessment of prognosis requires an extended follow-up in a larger cohort.

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“…They are often described as sellar lesions with frequent suprasellar extension and sellar enlargement (and/or bone remodelling). They generally present as isointense lesions on T1-weighted MRI and the posterior lobe of the pituitary gland is generally not identifiable, while they appear as hyperintense lesions on T2-weighted images (2,8). T1-weighted MRI sequences with gadolinium contrast enhancement may prove useful in diagnosis, as pituicytomas may appear brighter than classical adenomas due to their dense vascularisation (4).…”

Section: Discussionmentioning

confidence: 99%

An exceptional presentation of pituicytoma apoplexy: A case report

et al. 2018

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Abstract. Pituicytomas are a rare form of indolent neoplasms, which typically present with visual disturbance and hypopituitarism. Complete resection by a trans-sphenoidal approach is the optimal treatment. Only 80 cases have been described thus far in the current literature and the present case is the first to describe the development of pituitary apoplexy in the context of a pituicytoma. A 77-year-old man presented with fatigue and clinical signs of hypogonadism and a sellar lesion was diagnosed at cerebral magnetic resonance imaging (MRI). A watch-and-wait management was initially decided and 1 year after the initial diagnosis, he presented with a thunderclap headache with images suggestive of pituitary apoplexy. A pituitary adenoma was suspected and an endoscopic resection was decided upon the development of a visual deficit. Pathological analysis established the correct diagnosis of a pituicytoma. Pituicytomas are characterised by dense vascularisation, thus ischaemic and haemorrhagic events may be common. When confronted with a hypervascularised pituitary lesion demonstrating strong contrast enhancement and no abnormal hormonal secretion, one must maintain a high index of suspicion for a pituicytoma. A wide range of differential diagnoses should thus be considered in the context of pituitary apoplexy. IntroductionPituicytomas are rare slow-growing tumours arising from the glial cells of the neurohypophysis and infundibulum (pituicytes). The histogenesis, natural history and prognosis of these lesions still need to be elucidated, as data in the current literature remain scarce.Since the first reported case in 1955 (1), there has been a surge in the number of case reports and small case series describing this rare entity. There are no gender-specific differences in the incidence of pituicytomas, and the average age of presentation is 50 years of age (2). No specific risk factors were identified. These neoplasms generally present with headaches, visual disturbances and manifestations of hypopituitarism (typically sexual dysfunction). The clinical presentation is almost identical to other more frequent sellar lesions, therefore correctly diagnosing these lesions can be challenging. Of about 80 cases described in the literature up until now (3), only one previous case reported an abrupt onset of clinical features and this was due to an intraventricular haemorrhage (4).On imaging, even if pituicytomas present with suspicious radiological peculiarities, their rarity often leads them to be misdiagnosed for more common lesions. Surgical resection represents the mainstay of treatment, and this is typically via an endoscopic endonasal approach (5). However, complete resection may be challenging due to the firm consistency and highly vascularised nature of these tumours.We report a novel case of a pituicytoma presenting as pituitary apoplexy, with the aim to advance a hypothesis to explain this phenomenon. To our knowledge this is the first reported case in the literature that describes the development of pituitary ap...

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Magnetic Resonance Imaging and Pathological Analysis of a Pituicytoma

Cited by 60 publications

References 12 publications

Pituicytoma-Two Case Reports-

Pituicytoma-Two Case Reports-

Pituicytoma: A report of three cases and literature review

An exceptional presentation of pituicytoma apoplexy: A case report

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