Pituicytoma-Two Case Reports-

Nakasu, Yoko; Nakasu, Satoshi; Saito, Akira; Horiguchi, Satoshi; Kameya, Toru

doi:10.2176/nmc.46.152

Cited by 51 publications

(13 citation statements)

References 11 publications

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“…Depending on their state of differentiation, some pituicytomas do not express GFAP. However, ultrastructural features comparable to those described in human tumors (Nakasu et al 2006) have been previously described in pituicytoma cells positive for GFAP (Cenacchi et al 2001). These cells had features consistent with both pituicytoma and pituitary adenoma differentiation (i.e., aggregates of intermediate filaments and secretory granules), suggesting an origin of this tumor from stromal folliculostellate cells of the adenohypophysis.…”

Section: Primary Diagnostic Featuressupporting

confidence: 76%

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Weber¹,

Garman²,

Germann³

et al. 2010

Toxicol Pathol

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Neoplasms of the nervous system, whether spontaneous or induced, are infrequent in laboratory rodents and very rare in other laboratory animal species. The morphology of neural tumors depends on the intrinsic functions and properties of the cell type, the interactions between the neoplasm and surrounding normal tissue, and regressive changes. The incidence of neural neoplasms varies with sex, location, and age of tumor onset. Although the onset of spontaneous tumor development cannot be established in routine oncogenicity studies, calculations using the time of diagnosis (day of death) have revealed significant differences in tumor biology among different rat strains. In the central nervous system, granular cell tumors (a meningioma variant), followed by glial tumors, are the most common neoplasms in rats, whereas glial cell tumors are observed most frequently in mice. Central nervous system tumors usually affect the brain rather than the spinal cord. Other than adrenal gland pheochromocytomas, the most common neoplasms of the peripheral nervous system are schwannomas. Neural tumors may develop in the central nervous system and peripheral nervous system from other cell lineages (including extraneural elements like adipose tissue and lymphocytes), but such lesions are very rare in laboratory animals.

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Section: Primary Diagnostic Featuressupporting

confidence: 76%

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Weber¹,

Garman²,

Germann³

et al. 2010

Toxicol Pathol

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“…Although the neurohypophysis is associated with the storage and release of antidiuretic hormone, and is believed to be the origin of pituicytomas, only 5% of all reported cases presented with central diabetes insipidus (DI), for reasons that are unclear. 10 In our case, the patient also denied any symptoms of DI; her primary clinical presentation was Cushing syndrome.…”

Section: Discussionmentioning

confidence: 53%

Pituicytoma Coexisting With Corticotroph Hyperplasia

Guo

Kong

et al. 2016

Medicine

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Pituicytoma is a rare, low-grade glial neoplasm that arises in the neurohypophysis or infundibulum and usually presents as pituitary gland enlargement. They are often misdiagnosed as pituitary adenomas. Causes have varied for high serum adrenocorticotropic hormone level reported in a few patients with pituicytoma.We report a rare case of pituicytoma accompanied by corticotroph hyperplasia—a challenging diagnosis guided by clinical presentations, radiological signs, and biopsy.We present a case of pituicytoma with corticotroph hyperplasia in a 46-year-old woman with typical Cushing syndrome. Magnetic resonance imaging revealed a lesion in the sellar area with equal T1 and T2 signals and marked homogeneous enhancement. We present detailed analysis of the patient's disease course and review pertinent literature. Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor of this journal. Because of this, there is no need to conduct special ethic review and the ethical approval is not necessary.The patient underwent a surgical exploration and tumor resection through a trans-sphenoidal approach. Pathologic results revealed pituicytoma and corticotroph hyperplasia. As adrenocorticotropic hormone and cortisol levels did not decrease to normal, the patient received radiotherapy and recovered uneventfully. No recurrence was found over 8 years of follow-up.Pituicytoma is a rare type of sellar tumor. Pituicytomas in patients with Cushing syndrome are rarer still. To our knowledge, this is the first report of Cushing syndrome caused by corticotroph hyperplasia in a pituicytoma patient.

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“…Only one patient presented with diabetes insipidus, despite pituicytomas arising from the posterior pituitary gland or infundibulum [4]. Nakasu et al suggested that pituicytomas start to grow in the posterior lobe or lower portion of the stalk, so the upper neurohypophysis might have to compensate for the loss of function [5]. …”

Section: Discussionmentioning

confidence: 99%

Neuroimaging characteristics and growth pattern on magnetic resonance imaging in a 52-year-old man presenting with pituicytoma: a case report

et al. 2012

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IntroductionPituicytoma is a rare neoplasm of the neurohypophysis. To the best of our knowledge there have been no reports of pituicytoma in which long-term magnetic resonance imaging observation was performed. We calculated the doubling time of the tumor volume and described the growth pattern of a pituicytoma.Case presentationA 52-year-old Japanese man with a history of decreased libido was found to have a sellar and suprasellar mass. He underwent transsphenoidal surgery, but only a small specimen was obtained because of intraoperative bleeding. The tentative histological diagnosis was schwannoma. He noticed bitemporal hemianopsia 7 years later. A follow-up magnetic resonance imaging disclosed a tumor volume doubling time of 3830 days. Transcranial gross-total tumor resection was performed. The lesion consisted of elongated and plump tumor cells that were arranged in a fascicular or storiform pattern and were positive for S-100 protein and focally positive for glial fibrillary acidic protein. The final histological diagnosis was pituicytoma.ConclusionPituicytoma is a slow-growing tumor, but the growth rate may change during follow-up.

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Pituicytoma-Two Case Reports-

Cited by 51 publications

References 11 publications

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Pituicytoma Coexisting With Corticotroph Hyperplasia

Neuroimaging characteristics and growth pattern on magnetic resonance imaging in a 52-year-old man presenting with pituicytoma: a case report

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