Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered

McPherson, Stuart; Jonsson, Julie R.; Cowin, Gary; O’Rourke, Peter; Clouston, Andrew D.; Volp, Andrew; Horsfall, Leigh; Jothimani, Dinesh; Fawcett, Jonathan; Galloway, Graham J.; Benson, Mark D.; Powell, Elizabeth E.

doi:10.1016/j.jhep.2009.04.012

Cited by 160 publications

(160 citation statements)

References 28 publications

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“…In a similar study on cancer patients, the use of MTX led to an increase in ALT in 14% and AST in 8% of patients, although by discontinuing drug use within 1 month, the level of liver enzymes could return to the normal range (21). In the present study, no association was revealed between the grade of steatosis and severity of hepatic fibrosis that was also previously indicated in some studies (22)(23)(24)(25)(26). Overall, it could be concluded that FibroScan is a useful technique for assessing hepatic fibrosis in patients, who receive MTX.…”

Section: Discussionsupporting

confidence: 78%

Transient Elastography in Methotrexate Administered Patients

et al. 2017

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Section: Discussionsupporting

confidence: 78%

Transient Elastography in Methotrexate Administered Patients

et al. 2017

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“…Magnetic-resonance spectroscopy (MRS) is the best imaging modality to grade the severity of steatosis with high accuracy [25,26], but it is not broadly available and its routine application is not perceived practical in the pre-transplant setting. On the other hand, US is cheap and easily available, and provides good accuracy for the diagnosis of hepatic steatosis, but it is operator dependent with low inter-and intra-observer agreement on the severity of steatosis [16,19].…”

Section: Discussionmentioning

confidence: 99%

A Simple Model to Predict Moderate to Severe Steatosis in Obese Liver Donors

Martini¹,

Anty²,

Schneck³

et al. 2017

J Obes Chronic Dis

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Background: In the selection of marginal liver grafts most transplantation centers use a cut-off of 30% macrovesicular steatosis to define an acceptable risk of non-function. The aim of this prospective cohort study was to create a noninvasive model to predict >30% hepatic steatosis based on simple clinical and biochemical markers available at the time of potential liver-donor evaluation, to avoid futile and expensive procurement proceedings.

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“…In the MOZART study, mean PDFF trended downwards between F0-2 and F2-4 [31,34]. It is known that MRI may underestimate the amount of fat in hepatocytes when compared with histology in those with more advanced fibrosis because the number of hepatocytes per volume of liver is reduced, leading to an apparent reduction in liver fat [37]. Therefore, it is likely that fibrosis stage will need to be considered when measuring steatosis in patients with chronic liver disease [37].…”

Section: Magnetic Resonance Imaging-proton-derived Fat Fraction (Mri mentioning

confidence: 99%

“…It is known that MRI may underestimate the amount of fat in hepatocytes when compared with histology in those with more advanced fibrosis because the number of hepatocytes per volume of liver is reduced, leading to an apparent reduction in liver fat [37]. Therefore, it is likely that fibrosis stage will need to be considered when measuring steatosis in patients with chronic liver disease [37]. Concomitant assessment of liver fibrosis and steatosis by MRI may overcome this need [34], as discussed later in this review.…”

Section: Magnetic Resonance Imaging-proton-derived Fat Fraction (Mri mentioning

confidence: 99%

Imaging-Based Assessment of Steatosis, Inflammation and Fibrosis in NAFLD

Hardy

McPherson

2017

Curr Hepatology Rep

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Purpose of Review Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the Western world. Invasive liver biopsy remains the gold standard method for the diagnosis and staging of NAFLD. The aim of this review is to summarize recent research regarding imagingbased assessment of NAFLD. Recent Findings Novel methods such as controlled attenuation parameter (CAP) and magnetic resonance imaging proton-derived fat fraction (MRI-PDFF) appear promising for steatosis assessment and are currently undergoing validation in NAFLD. Fibrosis can be non-invasively assessed by transient elastography (TE), which is currently the best validated test in NAFLD. MR elastography (MRE) appears very sensitive for fibrosis detection. No imaging technique can accurately detect NASH. Summary TE is inexpensive and relatively widely available and can reliably exclude advanced fibrosis in NAFLD. MRI offers the most promise for steatosis and fibrosis quantification, but further validation of these techniques is needed.

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Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered

Cited by 160 publications

References 28 publications

Transient Elastography in Methotrexate Administered Patients

Transient Elastography in Methotrexate Administered Patients

A Simple Model to Predict Moderate to Severe Steatosis in Obese Liver Donors

Imaging-Based Assessment of Steatosis, Inflammation and Fibrosis in NAFLD

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