Magnetic resonance imaging and spectroscopy of the heart

A, de Roos; Ee, van der Wall

doi:10.1097/00001573-199112000-00014

Cited by 15 publications

(3 citation statements)

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“…The use of 31 P MRS, unlike classical proton spectroscopy, enables the detection of high-energy phosphates such as: ATP and phosphocreatine (PCr). Bhujwalla et al using markers of dimethyl methylphosphonate (DMMP), 3-aminopropylphosphonate, P assessed the quantitative concentration of intracellular and extracellular metabolites with MRS 31 P ap-assisted in solid tumors in vivo [ 157 , 158 ]. The group of de Roos et al used the classical MR method and the 31 P spectroscopic method, which can be combined to obtain complete cardiovascular diagnostics [ 158 ].…”

Section: Tracking In Vivomentioning

confidence: 99%

“…Bhujwalla et al using markers of dimethyl methylphosphonate (DMMP), 3-aminopropylphosphonate, P assessed the quantitative concentration of intracellular and extracellular metabolites with MRS 31 P ap-assisted in solid tumors in vivo [ 157 , 158 ]. The group of de Roos et al used the classical MR method and the 31 P spectroscopic method, which can be combined to obtain complete cardiovascular diagnostics [ 158 ]. In their work, the group of Kemp et al presented the evaluation of the concentration of metabolites [Pi] and [phosphocreatine (PCr)] by 31 P MRS in muscles in in vivo studies, eliminating the problem of measuring PCr and Pi signal intensity by phantom calibration [ 159 ].…”

Section: Tracking In Vivomentioning

confidence: 99%

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Multinuclear MRI in Drug Discovery

et al. 2022

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The continuous development of magnetic resonance imaging broadens the range of applications to newer areas. Using MRI, we can not only visualize, but also track pharmaceutical substances and labeled cells in both in vivo and in vitro tests. 1H is widely used in the MRI method, which is determined by its high content in the human body. The potential of the MRI method makes it an excellent tool for imaging the morphology of the examined objects, and also enables registration of changes at the level of metabolism. There are several reports in the scientific publications on the use of clinical MRI for in vitro tracking. The use of multinuclear MRI has great potential for scientific research and clinical studies. Tuning MRI scanners to the Larmor frequency of a given nucleus, allows imaging without tissue background. Heavy nuclei are components of both drugs and contrast agents and molecular complexes. The implementation of hyperpolarization techniques allows for better MRI sensitivity. The aim of this review is to present the use of multinuclear MRI for investigations in drug delivery.

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Section: Tracking In Vivomentioning

confidence: 99%

Section: Tracking In Vivomentioning

confidence: 99%

Multinuclear MRI in Drug Discovery

et al. 2022

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“…These range from the investigation of phosphate metabolism in muscle (10,11) to glucose metabolism in the brain (12). Standard localized spectroscopy techniques, such as point resolved spectroscopy (PRESS) or in vivo selected image spectroscopy (ISIS) utilize a selected rectangular volume (voxel) of tissue from which a spectrum is collected (13).…”

Section: Introductionmentioning

confidence: 99%

Determination of Aldose Reductase Activity in the Eye by Localized Magnetic Resonance Spectroscopy

Lizak

Mori

Kador

2001

Journal of Ocular Pharmacology and Therapeutics

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The polyol pathway plays an important role in the formation of diabetic complications of the eye. Due to variations in the pharmacokinetic properties of aldose reductase inhibitors and variations in the degradation of the blood-ocular barrier, it is often difficult to determine the proper intraocular levels of aldose reductase inhibitor required for inhibition of aldose reductase activity in ocular tissues. Utilizing localized magnetic resonance spectroscopy (MRS), the present method can determine adequate inhibition of aldose reductase activity in the lens by noninvasively measuring polyol pathway activity in the eye. New Zealand White rabbits, under anesthesia, were administered an intravitreal injection of 3-fluoro-3-deoxy-D-glucose (3FDG). Localized MRS was then used to assess polyol pathway activity by determining the levels of 3-fluoro-3-deoxy-D-sorbitol (3FS) and 3-fluoro-3-deoxy-D-fructose (3FF) metabolite formation from 3FDG in the eye. MRS was able to follow the loss of 3FDG from the vitreous into the anterior segment of the eye and particularly into the lens and aqueous. The primary metabolism of 3FDG observed by MRS was the formation of 3FS in the lens that is catalyzed by aldose reductase. Production of 3FS was linear in time and decreased with the oral administration of an aldose reductase inhibitor.

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Cardiac Imaging for the Assessment of Myocardial Viability

Kaul¹,

Linder²

1998

Unstable Coronary Artery Syndromes Pathophysiology, Diagnosis and Treatment

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Magnetic resonance imaging and spectroscopy of the heart

Cited by 15 publications

References 0 publications

Multinuclear MRI in Drug Discovery

Multinuclear MRI in Drug Discovery

Determination of Aldose Reductase Activity in the Eye by Localized Magnetic Resonance Spectroscopy

Cardiac Imaging for the Assessment of Myocardial Viability

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