Magnetic Resonance Imaging Assessment of Infantile Myofibromatosis

Counsell, Serena; DeVile, Catherine; Mercuri, E.; Allsop, JM; Birch, R; Muntoni, F.

doi:10.1053/crad.2001.0723

Cited by 21 publications

(28 citation statements)

References 20 publications

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“…According to several authors, hemangiopericytoma and infantile myofibromatosis are a continuous spectrum of a single myofibroblast disease (8). Therefore, the appearance on radiological investigation may vary on the basis of the abovementioned criteria (6).…”

Section: Discussionmentioning

confidence: 99%

“…For the abovementioned reasons, the determination of disease extent and progression with imaging are mandatory (6). US is the firststep examination, due to its availability, lack of ionizing radiation, and no need for sedation; however, the findings are often nonspecific, and US cannot fully investigate deep lesions, bone spread, visceral and lung involvement (3).…”

Section: Discussionmentioning

confidence: 99%

“…MRI is considered a gold standard imaging technique for soft tissue evaluation, due to its ability to provide a radiationfree detailed assessment of the disease, even without contrast media administration; it also enables early detection of visceral involvement in myofibromatosis (6). MRI may also provide high-accuracy musculoskeletal images and distinguish between various tissues, such as muscle, fibrous tissue and fat.…”

Section: Discussionmentioning

confidence: 99%

“…In radiological literature, myofibromatosis nodules usually display different MRI signals, depending on the main pattern of the lesions, or on their 'age', according to several authors (5,8): Younger nodules, characterized by an immature, highly vascular central component (hemangiopericytoma like) surrounded by bundles of myofibroblasts, are iso/hypointense on T1W images before and after contrast compound administration, and exhibit heterogeneous gadolinium (Gd) enhancement and high signal on T2W sequences (5,6). In older lesions, the immature core is replaced by mature myofibroblasts, or more often involutes in sheets of hyalinization or necrosis and calcification.…”

Section: Discussionmentioning

confidence: 99%

“…Clinical/radiological diagnosis and follow-up are crucial for determining disease localization and prognosis (6).…”

Section: Introductionmentioning

confidence: 99%

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Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

Salerno

Terranova

Rossello

et al. 2017

Molecular and Clinical Oncology

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Myofibromatosis is an uncommon disorder of infancy, characterized by proliferation of myofibroblasts in solitary or multiple nodules. The clinical characteristics depend on the involved sites: Myofibromatosis may develop as a musculoskeletal form, with non-painful swellings and eventual mass effect symptoms, or as a generalized form with visceral involvement and organ failure. Prognosis and therapy vary between the abovementioned patterns. When there is no visceral involvement, the tumors may regress spontaneously; however, the visceral form may represent a lifethreatening condition with poor outcome and it requires aggressive management. Imaging assessment of disease spread is mandatory to determine diagnosis, prognosis and therapy. Due to the young age of the patients, a radiation-free evaluation is recommended. We herein describe a case of musculoskeletal myofibromatosis diagnosed in a 3-month-old male infant, investigated by serial wholebody magnetic resonance imaging (MRI) examination. The histological analysis and MRI characteristics enabled a correct diagnosis and organ involvement assessment with no radiation exposure. Moreover, whole-body MRI sequences provided a detailed evaluation of the disease within a short time frame, reducing the time of sedation, which is required to perform MRI in very young patients. Therefore, whole-body MRI was found to be accurate and safe in the diagnosis and follow-up of multicentric infantile myofibromatosis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Clinical/radiological diagnosis and follow-up are crucial for determining disease localization and prognosis (6).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

Salerno

Terranova

Rossello

et al. 2017

Molecular and Clinical Oncology

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Risk‐adapted therapy for infantile myofibromatosis in children

Levine

Fréneaux

Schleiermacher

et al. 2011

Pediatric Blood & Cancer

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Infantile myofibromatosis is a rare soft tissue tumor mainly concerning infants. Surgery is the treatment of choice for solitary forms when excision is possible. Close follow-up may be proposed in the case of inoperable sites. In multicentric life-threatening forms, chemotherapy promotes tumor regression and the vinblastine and methotrexate combination is effective with few long-term adverse effects.

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Solitary myofibroma preceding the development of multicentric myofibromatosis: A report of two cases with surveillance recommendations

Todd

Kim

Szabo

et al. 2020

Pediatric Blood & Cancer

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Infantile myofibroma is the most common fibrous tumor of infancy. Despite the frequency of these tumors, the natural history is incompletely understood. We present two cases with a unique pattern of disease: solitary myofibromas with subsequent progression to diffuse myofibromatosis. Given the variable spectrum of disease and the corresponding difference in morbidity and potential mortality based on the extent of disease, we propose surveillance recommendations.

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Magnetic Resonance Imaging Assessment of Infantile Myofibromatosis

Cited by 21 publications

References 20 publications

Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

Whole-body magnetic resonance imaging in the diagnosis and follow-up of multicentric infantile myofibromatosis: A case report

Risk‐adapted therapy for infantile myofibromatosis in children

Solitary myofibroma preceding the development of multicentric myofibromatosis: A report of two cases with surveillance recommendations

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