Magnetic resonance imaging findings in Tay–Sachs disease

Gupta, Laxmikant; Mirza, Arif; Gulati, Achal; Gulati, Parveen

doi:10.4103/0028-3886.236955

Cited by 1 publication

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“…31 In addition, it used to anticipate coronary illness, 32 stroke, 33 and to diminish blood levels of homocysteine. 34 FA is significant for anticipating the eye infection age-related macular degeneration, 35 age-related hearing misfortune, 36 osteoporosis, 37 diminishing indications of maturing, 38 nerve torment, 39 and depression. 40 In cancer cells that have an accelerated DNA replication and cell division rate, high folate concentrations are required for methylation processes, and metabolic pathways that could induce carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and biological activities of folic acid conjugates with polyvinyl alcohol, chitosan, and cellulose

El‐Naggar

El‐Barbary

Salama

et al. 2022

J of Applied Polymer Sci

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Polyvinyl alcohol (PVA), chitosan (CS), and cellulose (CL) are promising polymers for chemical functionalization and biomedical applications. This study aimed to synthesize folic acid (FA) conjugates with PVA, CS, and CL via chloroacetyl chloride, 2-bromopropionyl bromide, and epichlorohydrin to enhance it biomedical applications. The functionalized polymer conjugates were characterized by FT-IR, 1 H-NMR, GPC, and TGA techniques. FT-IR and 1 H-NMR revealed the main functional groups (O H, N H, C═O, C═N), the aromatic C H and N H protons of FA moieties. TGA illustrated two stages of decompositions of all-polymer conjugates. FA showed no antifungal activity, while two of the newly grafted polymer conjugates (chitosan bromopropionate-grafted FA and cellulose chloroacetate-grafted FA) illustrated antifungal activity against both Aspergillus fumigatus and Candida albicans. Polymer conjugates; poly(vinyl chloroacetate)-grafted FA and chitosan-EPCH-grafted FA revealed good antifungal effect on C. albicans and A. fumigatus, respectively. Most FA polymer conjugates showed significant antitumor activity against EAC-bearing mice. Among these conjugates, chitosan chloroacetate-grafted FA (P-2A) showed the highest antitumor effect against EAC-bearing mice via reduction in total tumor volume. Thus, these conjugates provided enhanced antifungal and antitumor activities as compared with FA itself. These conjugates may act as promising biologically active carrier systems for other applications such as drug delivery.

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