Magnetic resonance imaging in boys with severe hemophilia A: Serial and end‐of‐study findings from the Canadian Hemophilia Primary Prophylaxis Study

Stimec, Jennifer; Dover, Saunya; Pullenayegum, Eleanor; Blanchette, Victor S.; Doria, A.; Feldman, Brian M.; Carção, Manuel; Rivard, Georges E.; Israels, Sara J.; Chan, Anthony; Steele, MacGregor; Cloutier, Stéphanie; Klaassen, Robert J.; Price, Victoria; Sinha, Roona; Laferriere, Nicole; Paradis, Elizabeth; Wu, John; Babyn, Paul

doi:10.1002/rth2.12565

Cited by 7 publications

(7 citation statements)

References 33 publications

(80 reference statements)

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“…wileyonlinelibrary.com/journal/hae haemosiderin on interval MRIs was associated with new osteochondral MRI changes at follow-up (OR = 4.7 and 5.3 respectively). 16 These results emphasize the importance of monitoring joint status in PwH using imaging which may be used to guide treatment.…”

Section: Mri Detects Previous (Subclinical) Bleedingmentioning

confidence: 76%

“…The pooled prevalence of asymptomatic cartilage defects was 11% for subjects < 40 years and 43% for subjects ≥40 years 22 . In PwH, self‐reported joint bleeds were associated with new osteochondral changes on MRI during follow‐up 16 . These may later on progress into more severe arthropathy as observed in another study that showed that osteochondral MRI abnormalities were strongly associated with the development of abnormalities on x‐rays 5 years later 15 .…”

Section: Mri Evaluation Of Osteochondral Abnormalitiesmentioning

confidence: 85%

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The relevance of MRI findings in joints of persons with haemophilia: Insights from the last decade

Foppen,

van Leeuwen,

Timmer

et al. 2024

Haemophilia

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Most bleeding episodes in persons with haemophilia (PwH) occur in the large synovial joints (elbows, knees, and ankles). Recurrent joint bleeding eventually leads to irreversible haemophilic arthropathy, which causes pain, reduced functionality, and thus reduced quality of life. Prophylactic treatment prevents most bleeding episodes. 1 Even in the absence of clinically overt joint bleeding, long-term progression to arthropathy is observed. Subclinical bleeding and inflammation are therefore thought to contribute to the development of arthropathy. 2-4 Detection of these subclinical processes is becoming increasingly important in the prevention of arthropathy in PwH as overt spontaneous joint bleeding is almost completely avoided by prophylaxis with new (non-factor) replacement therapies. 5 Magnetic resonance imaging (MRI) is considered the gold standard for evaluation of early blood-induced joint changes in PwH. In 2005, the International Prophylaxis Study Group (IPSG) published compatible scales for progressive and additive MRI assessment based on the Denver MRI score and the European MRI score. 6 These scores were combined in a comprehensive scoring scheme in 2012. 7 Based on an appraisal of the original IPSG MRI scale, 8 the score is now updated to the IPSG MRI Scale version 2.0 by Lundin and colleagues. 9 To provide more insight on the clinical relevance of MRI findings, we provide an overview of research on the clinical relevance of MRI findings evaluated by IPSG MRI Scale version 2.0.

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Section: Mri Detects Previous (Subclinical) Bleedingmentioning

confidence: 76%

Section: Mri Evaluation Of Osteochondral Abnormalitiesmentioning

confidence: 85%

The relevance of MRI findings in joints of persons with haemophilia: Insights from the last decade

Foppen,

van Leeuwen,

Timmer

et al. 2024

Haemophilia

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“…Nihal Bakeer 2 Amy L. Dunn 3 Sridhar Gibikote 4 Shyamkumar N. Keshava 4 Rolf C. R. Ljung 5 Olympia Papakonstantinou 6 Helen Pergantou 7…”

Section: Funding Informationmentioning

confidence: 99%

International Prophylaxis Study Group (IPSG) haemophilia joint MRI scale version 2.0

Lundin,

Bakeer,

Dunn

et al. 2024

Haemophilia

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“… 28 MRI studies examining joint changes over time generally reveal that soft tissue changes can be reversed, whereas alterations in bone and cartilage are irreversible. 29 Contemporary suggestions recommend the use of refractory synovitis to describe irreversible synovitis that persists for more than three months. 30 Therefore, the early diagnosis and appropriate treatment of synovitis are considered important for preventing the progression of arthropathy.…”

Section: Hemophilic Arthropathymentioning

confidence: 99%

Current Status and Challenges in Delivering Comprehensive Care for Patients with Hemophilia

Nomura

2023

JBM

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The importance of comprehensive care as a treatment strategy for patients with hemophilia is recognized worldwide. Comprehensive care entails addressing full spectrum of medical and psychological aspects impacting both patients and their families. The primary objective of comprehensive care for individuals with hemophilia is to enable them to lead their daily lives just as anyone else would. To achieve this goal, it is necessary to have a positive and collaborative approach across various healthcare disciplines. This extends beyond clinical specialists, encompassing pediatricians, hematologists, orthopedic surgeons, dental and oral surgeons, gynecologists, nurses, physical therapists, clinical psychologists, and other professionals from diverse fields. This review article discusses the current status and challenges associated with comprehensive care for patients with hemophilia. We categorize these challenges as follows: hemophilic arthritis, rehabilitation, oral care, transitioning from pediatric to adult care, addressing carrier issues, and providing psychological care. There is still substantial work to be undertaken in addressing these hurdles and advancing the quality of comprehensive care for hemophilia patients.

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Magnetic resonance imaging in boys with severe hemophilia A: Serial and end‐of‐study findings from the Canadian Hemophilia Primary Prophylaxis Study

Cited by 7 publications

References 33 publications

The relevance of MRI findings in joints of persons with haemophilia: Insights from the last decade

The relevance of MRI findings in joints of persons with haemophilia: Insights from the last decade

International Prophylaxis Study Group (IPSG) haemophilia joint MRI scale version 2.0

Current Status and Challenges in Delivering Comprehensive Care for Patients with Hemophilia

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