Magnetic resonance imaging in carcinoma cervix- Does it have a prognostic relevance

Abstract

In cervical cancer, the volume of disease as assessed on MRI may be a better prognostic indicator than FIGO staging and needs further evaluation.

Sequential magnetic resonance imaging of cervical cancer

“…Tumor regression can be better quantified, and early results have shown that tumor regression correlates with outcome. Most such studies of tumor volume and outcome in cervical cancer have assessed tumors before therapy or after completion of therapy 9, 10, 13, and only a few have obtained intra-treatment measurements 11, 12. With the large individual variations in initial tumor volumes and tumor regression rates of the reported data the best parameter threshold values and optimal timing for tumor volume measurement and it regression rate have not been well established for practical clinical translation.…”

“…Various tumor parameters and time points for MRI measurements have been suggested for outcome prediction, including pre-, during, and post-therapy follow-up 9-13. However, the simple practical paradigm and parameter thresholds for clinical implementation based upon such large and varied quantity of imaging data, including the imaging timing, has not been well defined or validated clinically with a long-term clinical study.…”

The Prognostic Value of the Metabolic Tumor Volume in FIGO stage IA to IIB Cervical Cancer for Tumor Recurrence: Measured by F-18 FDG PET/CT

“…Miller and Grigsby [13] evaluated the value of the tumor volume measurement using FDG-PET in patients with advanced cervical cancer and found that the tumor volume was predictive of the progression-free survival. Previous investigators showed that tumor size is an important prognostic factor in patients with cervical carcinoma [18,19]. Tumor volume has been measured with CT and MRI until recently.…”

Radiomic features of cervical cancer on T2-and diffusion-weighted MRI: Prognostic value in low-volume tumors suitable for trachelectomy

“…Additionally, patients could be counselled as to the need for adjuvant therapy at the outset. In larger tumors, where volume is a strong predictive factor of recurrence [31] and survival [32], the utility of additional radiomic analyses in altering management remains to be established.…”