Magnetic Resonance Imaging of Acute Myocardial Infarction in Pigs Using Gd-DTPA

Wikstrom, M.; Martinussen, H. J.; Wikstrom, G.; Ericsson, A.; Nyman, R.; Waldenstrom, A.; Hemmingsson, A.

doi:10.3109/02841859009173109

SRAD

1990

DOI: 10.3109/02841859009173109

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Magnetic Resonance Imaging of Acute Myocardial Infarction in Pigs Using Gd-DTPA

M. Wikstrom¹,

H. J. Martinussen²,

G. Wikstrom³

et al.

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Cited by 3 publications

(1 citation statement)

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“…The positive contrast agents Gd-DTPA (13) and Gd-DTPA-BMA (12) resulted in stronger enhancement of infarcted myocardium than nonischemic myocardium. The administration of the negative contrast agent Dy-DTPA-BMA improved infarction visualization by reducing signal intensity in nonischemic myocardium (7,12).…”

mentioning

confidence: 96%

MR Imaging of Double-Contrast Enhanced Porcine Myocardial Infarction

et al. 1995

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MR imaging was performed to investigate whether Gd-DTPA-BMA-induced contrast enhancement of myocardial infarction is counteracted by Dy-DTPA-BMA. Myocardial infarction was induced in 5 pigs. Microdialysate probes were inserted in ischemic and nonischemic myocardium. Gd-DTPA-BMA (0.3 mmol/kg b.w.) and Dy-DTPA-BMA (1.0 mmol/kg b.w.) were administered i.v. 4 hours post occlusion. The microdialysate was collected every 10 min and measured for Gd and Dy using inductively coupled plasma atomic emission spectrometry. The pigs were sacrificed 2 hours after administration of contrast media. The concentration of both contrast agents was 3 times higher in infarcted myocardium than in nonischemic myocardium. The infarctions displayed high signal intensity in spin-echo sequences ex vivo. This lack of detectable susceptibility effects from Dy may be caused by loss of cell membrane integrity in infarcted tissue as shown by our microdialysate and biopsy data.

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mentioning

confidence: 96%

MR Imaging of Double-Contrast Enhanced Porcine Myocardial Infarction

et al. 1995

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The contributory role of interstitial water in Gd‐DTPA‐enhanced MRI in myocardial infarction

Inoue

Murakami

Ochiai

et al. 1999

J. Magn. Reson. Imaging

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Sequential analysis of infarcted and normal myocardium in piglets using in vivo gadolinium-enhanced MR images

Dijkman

Höld

Laarse

et al. 1993

Magnetic Resonance Imaging

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Magnetic Resonance Imaging of Acute Myocardial Infarction in Pigs Using Gd-DTPA

Cited by 3 publications

References 0 publications

MR Imaging of Double-Contrast Enhanced Porcine Myocardial Infarction

MR Imaging of Double-Contrast Enhanced Porcine Myocardial Infarction

The contributory role of interstitial water in Gd‐DTPA‐enhanced MRI in myocardial infarction

Sequential analysis of infarcted and normal myocardium in piglets using in vivo gadolinium-enhanced MR images

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