Magnetic resonance imaging of disturbances in neuronal migration: illustration of an embryologic process.

Smith, A S; Blasér, Susan; Ross, Jeffery S.; Weinstein, Mark D.

doi:10.1148/radiographics.9.3.2727358

Cited by 17 publications

(9 citation statements)

References 14 publications

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“…The imaging characteristics of the mass in this report were consistent with normal gray matter, except that the tissue was ectopic, formed a mass that was highly cellular, and due to its location resulted in obstructive hydrocephalus. Similar to the cat in this report, gray matter heterotopias in humans remain isointense in comparison to normal gray matter across multiple MRI sequences, including T2W, T2‐FLAIR, T2 * W, and T1W images pre‐ and postcontrast . Diffusion weighted imaging were also similar in that the images indicated restriction of water movement.…”

Section: Discussionsupporting

confidence: 75%

Imaging Diagnosis—magnetic Resonance Imaging of a Neuronal Heterotopia in the Brain of a Cat

DeJesus¹,

Turek

Galban

et al. 2016

Vet Radiology Ultrasound

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A domestic shorthair kitten was presented for evaluation and further treatment of seizures. Magnetic resonance imaging of the brain revealed a large multilobulated mass in the third ventricle extending into the right lateral ventricle with secondary obstructive hydrocephalus. The mass was homogeneously isointense to gray matter on T2W, T2-FLAIR, T2 W, T1W, and ADC images, and hyperintense on DW-EPI. There was no appreciable contrast enhancement. Seizures were managed medically and with subsequent ventriculoperitoneal shunt placement. Clinical status later deteriorated and the cat was euthanized. Histopathology confirmed that the mass was the result of neuronal heterotopia. To the authors' knowledge this is the first report of neuronal heterotopia in a cat.

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Section: Discussionsupporting

confidence: 75%

Imaging Diagnosis—magnetic Resonance Imaging of a Neuronal Heterotopia in the Brain of a Cat

DeJesus¹,

Turek

Galban

et al. 2016

Vet Radiology Ultrasound

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“…However, this case was based on MR findings only because MRI showed abnormal structures of lissencephaly and necropsy was not performed. In recent years, the correlation between histopathological and imaging features has been well established; therefore, the diagnosis of lissencephaly by imaging alone is now well accepted in humans and dogs [1,14,16]. In this case, MRI was an efficient imaging modality for antemortem diagnosis of lissencephaly in a dog.…”

mentioning

confidence: 86%

Clinical and MRI Findings of Lissencephaly in a Mixed Breed Dog

et al. 2011

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ABSTRACT. A 7-year-old castrated male mixed-breed dog was presented with a complaint of acute pain. The dog had suffered from isolated seizures for two years. Magnetic resonance imaging (MRI) of the brain revealed a smooth brain surface due to lack of gyri and sulci formation of the cerebrum and thick cortical grey matter. Additionally, ventriculomegaly and an arachnoid cyst were noted. Multiple spinal cord compressions induced by intervertebral disc protrusion were observed on a cervical MRI. Based on these findings, the dog was diagnosed as having lissencephaly concurrent with intervertebral cervical disease. After therapy for seizure and cervical pain, the clinical signs were completely resolved. To the author's knowledge, this is the case report to diagnose lissencephaly in a mixedbreed dog.

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“…Heterotopia may be associated with pachygyria, agenesis of the corpus callosum, Chiari II malformation, arachnoid cyst, schizencephaly, and cephalocele. 1,2,6,34,35 Periventricular (Subependymal) Heterotopias Periventricular (subependymal) heterotopias (PVH) are located in close proximity to the ventricular wall. They are commonly seen in the region of the trigone and occipital horns of the lateral ventricles.…”

Section: 33mentioning

confidence: 99%

“…MR imaging is a valuable tool in the diagnosis of these disorders. [1][2][3][4][5][6] The purpose of this article was to review the embryologic stages of the cerebral cortex, illustrate the classification of the disorders of cortical formation, and finally describe the main MR imaging features of these disorders.…”

mentioning

confidence: 99%

Disorders of Cortical Formation: MR Imaging Features

Razek¹,

Kandell²,

Elsorogy³

et al. 2008

AJNR Am J Neuroradiol

146

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SUMMARY:The purpose of this article was to review the embryologic stages of the cerebral cortex, illustrate the classification of disorders of cortical formation, and finally describe the main MR imaging features of these disorders. Disorders of cortical formation are classified according to the embryologic stage of the cerebral cortex at which the abnormality occurred. MR imaging shows diminished cortical thickness and sulcation in microcephaly, enlarged dysplastic cortex in hemimegalencephaly, and ipsilateral focal cortical thickening with radial hyperintense bands in focal cortical dysplasia. MR imaging detects smooth brain in classic lissencephaly, the nodular cortex with cobblestone cortex with congenital muscular dystrophy, and the ectopic position of the gray matter with heterotopias. MR imaging can detect polymicrogyria and related syndromes as well as the types of schizencephaly. We concluded that MR imaging is essential to demonstrate the morphology, distribution, and extent of different disorders of cortical formation as well as the associated anomalies and related syndromes.

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Magnetic resonance imaging of disturbances in neuronal migration: illustration of an embryologic process.

Cited by 17 publications

References 14 publications

Imaging Diagnosis—magnetic Resonance Imaging of a Neuronal Heterotopia in the Brain of a Cat

Imaging Diagnosis—magnetic Resonance Imaging of a Neuronal Heterotopia in the Brain of a Cat

Clinical and MRI Findings of Lissencephaly in a Mixed Breed Dog

Disorders of Cortical Formation: MR Imaging Features

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