Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study

Smet, M Mariska de; Heijman, Edwin; Langereis, Sander; Hijnen, NM Nicole; Grüll, Holger

doi:10.1016/j.jconrel.2010.10.036

Cited by 298 publications

(248 citation statements)

References 38 publications

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“…Recently, there has been increasing interest in using ultrasound (US) as a means to physically and non-invasively trigger drug release from liposomes upon accumulation in tumour tissue (de Smet et al, 2010;Schroeder et al, 2009;Myhr and Moan, 2006;Pong et al, 2006). Local application of US to tumours produces several effects, such as enhancing extravasation of liposomes to tumours, inducing drug leakage from the liposome carrier and enhancing cell membrane permeability with a resulting increased intracellular drug uptake (For recent reviews see Schroeder et al, 2009;Pitt et al, 2004;Frenkel, 2008).…”

Section: Introductionmentioning

confidence: 99%

Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin

Evjen¹,

Hagtvet

Nilssen³

et al. 2011

European Journal of Pharmaceutical Sciences

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Ultrasound sensitive (sonosensitive liposomes) are drug delivery systems designed for releasing their drug load upon exposure to ultrasound (US). Inclusion of dioleoylphosphatidylethanolamine (DOPE) in liposome membranes was previously shown to induce sonosensitivity. For efficient US mediated drug delivery to solid tumours, a long blood circulation time of the liposomal drug providing high tumour uptake is required. In this study, blood pharmacokinetics of DOPE-based liposomal doxorubicin (DXR) were evaluated in mice. A markedly faster blood clearance of DXR was observed for DOPE-rich liposomes compared to Caelyx! (standard liposomal DXR). Subsequently, liposome membrane composition was altered to improve drug retention in the bloodstream, while maintaining sonosensitivity. Formulations with reduced blood clearance of DXR were obtained by reducing the content of DOPE from 62 to 32 or 25 mol%. These formulations showed long blood circulation time, as approximately 20% of the administered DXR dose was present in the bloodstream 24 h after intravenous injection. The reduction in liposomal DOPE content did not significantly reduce US mediated DXR release in vitro, indicating that DOPE is a potent modulator to sonosensitivity. The novel liposome formulations, containing moderate amounts of DOPE, displayed similar blood pharmacokinetic profiles as standard liposomal DXR, but a markedly improved sonosensitivity.

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Section: Introductionmentioning

confidence: 99%

Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin

Evjen¹,

Hagtvet

Nilssen³

et al. 2011

European Journal of Pharmaceutical Sciences

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“…The concept of temperature-triggered drug delivery has been extended to magnetic resonance (MR) image-guided drug delivery by the coencapsulation of a paramagnetic magnetic resonance imaging (MRI) contrast agent in the lumen of TSLs (Fig. 3) [49]. MR image-guided drug delivery illustration of the release of temperature-triggered drug using temperaturesensitive liposomes and HIFU.…”

Section: Temperature-sensitive Drug Deliverymentioning

confidence: 99%

“…MR image-guided drug delivery illustration of the release of temperature-triggered drug using temperaturesensitive liposomes and HIFU. The co-release of MRI contrast agents from the liposome loaded with temperature-sensitive drug allows to non-invasively visualize and quantify the drug release process [49].…”

Section: Temperature-sensitive Drug Deliverymentioning

confidence: 99%

Smart Drug Delivery Strategies Based on Porous Nanostructure Materials

Wang¹,

Huang²,

Lai³

2016

Smart Drug Delivery System

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The control of drug delivery can have a great effect on its efficacy. An optimum concentration range of drugs can play a significant role in the human body, and it can cause harm to humans when it exceeds the range of the drug concentration. Recently, a variety of drug deliveries and their targeted systems have been studied to minimize drug loss and maximize the amount of drug accumulated in the required area, thus increasing drug bioavailability. In addition, we should especially consider the prevention of its harmful side-effects in the human body. Innovative drug delivery systems based on biodegradable, natural or synthetic polymers, micro-or nano-particles, lipoproteins, micelles, TiO 2 nanotube arrays (TNTs), nanoporous anodic aluminum oxide (AAO), and so on were developed, which combined magnetic targeting and stimulus-responsive in drug delivery systems. The composition of delivery carriers and the stimulus-responsive elements proved stimulus-responsive drug release as a smart drug delivery system.

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“…Dedicated hybrid systems have already been introduced into clinical applications. 15,78,79 Localized drug release from TSL has been demonstrated in rodents, 55,80 and nonrodents, [81][82][83] using MRI for the control of hyperthermia. Beyond controlling the volume of heating, encapsulation of MRI contrast agents in TSL formulations allows additional characterization of the drug delivery only accessible in humans when using MRI.…”

Section: Thermosensitive Liposomes For Mri-guided Drug Deliverymentioning

confidence: 99%

“…53 A traditional temperature-sensitive liposome (TTSL) formulation with coencapsulated doxorubicin and a gadolinium-based contrast agent for MRI-guided delivery of doxorubicin is currently under investigation. [54][55][56][57] The TTSL formulation has been used in these studies because of its higher stability when compared with lysolipidcontaining low temperature-sensitive liposome (LTSL) formulations. 54 …”

mentioning

confidence: 99%

Thermosensitive liposomal drug delivery systems: state of the art review

Kneidl¹,

Peller²,

Winter³

et al. 2014

IJN

148

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Thermosensitive liposomes are a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. Up to March 2014, the Web of Science listed 371 original papers in this field, with 45 in 2013 alone. Several formulations have been developed since 1978, with lysolipid-containing, low temperature-sensitive liposomes currently under clinical investigation. This review summarizes the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Further, treatment strategies for solid tumors are discussed. Here we focus on temperature-triggered intravascular and interstitial drug release. Drug delivery guided by magnetic resonance imaging further adds the possibility of performing online monitoring of a heating focus to calculate locally released drug concentrations and to externally control drug release by steering the heating volume and power. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristic of this nanotechnology approach in medicine.

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Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study

Cited by 298 publications

References 38 publications

Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin

Sonosensitive dioleoylphosphatidylethanolamine-containing liposomes with prolonged blood circulation time of doxorubicin

Smart Drug Delivery Strategies Based on Porous Nanostructure Materials

Thermosensitive liposomal drug delivery systems: state of the art review

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