Magnetic Resonance Imaging of Intercranial Plasmocytic Granuloma

Wilner, Harvey I.; Viñas, Federico C.; Duffy, Colleen; Kupsky, William J.; Guthikonda, Murali

doi:10.1055/s-2008-1058136

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…We found 19 other cases of PCG presenting as an intraaxial mass ( Table 2). Of these 19 cases, fourteen patients had a single mass [24,25,27,[34][35][36][37][38][39][40][41][42][43][44], while five had multiple lesions [9,17,[45][46][47]. The majority of the patients (11 out of 19) did not have recurrence of the lesion on follow-up ranging from 3 months to 4 years.…”

Section: Intraaxial Pcgmentioning

confidence: 99%

Primary intracranial plasma cell granulomas presenting as malignant neoplasms

et al. 2011

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Plasma cell granuloma (PCG) is an uncommon non-neoplastic mass lesion of unknown etiology. It is characterized by a polyclonal proliferation of chronic inflammatory cells, mostly mature plasma and other mononuclear cells. PCGs arising in the central nervous system are particularly rare. We report two additional cases of intracranial PCG exclusively involving the brain parenchyma. A 47 year-old woman, presenting with partial motor seizures and fluent aphasia, underwent complete excision of a well-demarcated, enhancing left parietal mass. The second patient was a 56 year-old man presenting with headaches and right-sided weakness who underwent stereotactic biopsy of an ill-defined, heterogeneously enhancing lesion in the left basal ganglia. Immunohistochemical analysis of surgical specimens showed polyclonal plasma cells and mature lymphocytes but no etiological agent. A histopathologic diagnosis of intracranial PCG was made in both cases. PCG should be part of the differential diagnosis of enhancing mass lesions of the brain. The etiology and natural history of these tumor-like lesions is not fully understood. Complete surgical excision appears to be curative. Lesions where total resection is not possible may benefit from adjuvant treatment including corticosteroids and possibly radiation therapy.

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