Magnetic resonance imaging of intracranial hemangiopericytoma and correlation with pathological findings

Abstract

The present study aimed to evaluate the radiological and pathological features of intracranial hemangiopericytoma, and improve the understanding of this tumor. A retrospective analysis of radiological and pathological features of five cases of intracranial hemangiopericytoma was conducted between 2006 and 2012 in the Second Xiangya Hospital of Central South University. A total of five cases (three males and two females; aged 37–60 years) were enrolled. Magnetic resonance imaging revealed that the lesions were lobulated with iso-intensity T1-weighted image signals and slightly long T2-weighted image signals. Cystic degeneration, necrosis and flow void were observed. The case with the lesion located under the tentorium cerebelli exhibited compression of the fourth ventricle with lateral ventricle dilatation hydrocephalus. In all cases, the solid section of the lesion was markedly enhanced following injection of the contrast agent, and intratumoral vessels were observed. No case exhibited the dural tail sign. Immunohistochemical examination revealed positive expression of cluster of differentiation 34(CD34), vimentin and CD99, and negative expression of epithelial membrane antigen, S100 and glial fibrillary acidic protein. Proliferating cell nuclear antigen Ki-67 immunohistochemical staining revealed that <5% of cells expressed Ki-67 in two cases and 5–10% of cells expressed Ki-67 in three cases. In conclusion, intracranial hemangiopericytoma exhibits certain distinctive characteristics in radiological examination, allowing for improved diagnosis. However, pathological examination is required for confirmation.

Multidisciplinary Approach to Hepatic Metastases of Intracranial Hemangiopericytoma: A Case Report and Review of the Literature

“…Clinical symptoms are vague and nonspecific, depending on tumor location and size [ 4 ]. Pain is usually a late presentation, while hypoglycemia represents a unique endocrine paraneoplastic syndrome, caused by oversecretion of insulin-like growth factor II [ 5 ].…”

“…Magnetic resonance imaging reveals well-defined, lobular lesions, with an isointense signal in T1WI and slightly long signal in T2WI unenhanced scans. Following gadolinium administration, a heterogeneous enhancement is observed, due to cystic degeneration, focal tumor necrosis, or flow voids [ 4 , 6 ].…”

“…Unlike meningioma, which has a hyperplastic effect on adjacent bone, HPCs are shown to exert an osteolytic effect. Moreover, no dural tail sign is observed [ 4 , 6 ].…”

Visual qualitative evaluation of diffusion-weighted imaging, apparent diffusion coefficient quantification and Ki-67 proliferation index for predicting atypia in surgical meningiomas

“…On the other hand, it is still difficult to distinguish lowgrade meningiomas from atypical meningiomas using conventional MR imaging, since both entities may have similar findings. Even though, nonpresence of calcification, heterogeneous enhancement, necrosis, irregular margins, intense perifocal edema, or mushrooming patterns on imaging suggests atypical or malignant meningiomas, these findings are insufficient to evaluate atypia in meningioma [3,4,[6][7][8][9][15][16][17][18][19]. The pre-surgical evaluation of atypia is crucial to predict the prognosis and the risk of recurrence in patients with meningiomas.…”

Hemangiopericytoma: A Rare Case Report

“…Adjuvant therapies such as radiation therapy are most often used in cases which are inoperable or which have reappeared after optimal treatment or for palliative care. Chemotherapy however is not routinely employed and is used as an adjunctive therapy with more important role in inoperable cases and cases with metastases (Tang et al, 1988;Espat et al, 2002;Ma et al, 2014).…”