Magnetic resonance imaging of isolated single liposome by magnetic resonance force microscopy

Tsuji, Shintaro; Masumizu, Toshiki; Yoshinari, Y.

doi:10.1016/j.jmr.2003.12.011

Cited by 23 publications

(21 citation statements)

References 31 publications

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“…Unlike previous MRFM imaging experiments, the MRFM image did not show ringlike features associated with the resonant slice point spread function 14,28,29 . This is due to the extreme sharpness of the magnetic tip, which leads to a compact resonant slice with a radius of curvature that is comparable to the 100 nm sample features.…”

Section: Two Dimensional Imaging Using Cyclic-cermit Protocolcontrasting

confidence: 85%

Nuclear magnetic resonance imaging with 90-nm resolution

et al. 2007

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Magnetic resonance imaging, based on the manipulation and detection of nuclear spins, is a powerful imaging technique that typically operates on the scale of millimeters to microns. Using magnetic resonance force microscopy, we have demonstrated that magnetic resonance imaging of nuclear spins can be extended to a spatial resolution better than 100 nm. The two-dimensional imaging of 19 F nuclei was done on a patterned CaF 2 test object, and was enabled by a detection sensitivity of roughly 1200 nuclear spins. To achieve this sensitivity, we developed high-moment magnetic tips that produced field gradients up to 1.4×10 6 T/m, and implemented a measurement protocol based on force-gradient detection of naturally occurring spin fluctuations. The resulting detection volume of less than 650 zl represents 60,000× smaller volume than previous NMR microscopy and demonstrates the feasibility of pushing magnetic resonance imaging into the nanoscale regime.

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Section: Two Dimensional Imaging Using Cyclic-cermit Protocolcontrasting

confidence: 85%

Nuclear magnetic resonance imaging with 90-nm resolution

et al. 2007

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“…72,73 In an exciting first step towards a biological application, a nitroxide-labeled liposome membrane was prepared and imaged by MRFM. 74 Resolution in three dimensional ͑3D͒ ESR imaging experiments has been pushed to nanometer scale by working with gradient sources as small as 5 m mounted to a commercial silicon nitride cantilever. 75 Many of these experiments required long imaging times, achieved with careful closed-loop control of scanning; 76,77 acquisition times as long as ten days have been demonstrated in a 3D ESR imaging experiment.…”

Section: Imagingmentioning

confidence: 99%

“…40 Imaging. The established MRFM image-reconstruction protocols 47,69,70,[74][75][76] have been designed to image Curie-law magnetization. With a sufficiently sharp tip and a thin planar sample, an image of small-ensemble magnetization fluctuations can be acquired directly by scanning, as the 90 nm resolution fluorine imaging experiment of Ref.…”

Section: Future Directions In Mechanically Detected Magnetic Resmentioning

confidence: 99%

Advances in mechanical detection of magnetic resonance

Kuehn

Hickman

Marohn

2008

The Journal of Chemical Physics

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The invention and initial demonstration of magnetic resonance force microscopy (MRFM) in the early 1990s launched a renaissance of mechanical approaches to detecting magnetic resonance. This article reviews progress made in MRFM in the last decade, including the demonstration of scanned probe detection of magnetic resonance (electron spin resonance, ferromagnetic resonance, and nuclear magnetic resonance) and the mechanical detection of electron spin resonance from a single spin. Force and force-gradient approaches to mechanical detection are reviewed and recent related work using attonewton sensitivity cantilevers to probe minute fluctuating electric fields near surfaces is discussed. Given recent progress, pushing MRFM to single proton sensitivity remains an exciting possibility. We will survey some practical and fundamental issues that must be resolved to meet this challenge.

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“…However, SFM is unable to identify the fundamental origins of such anomalies, for instance whether they are caused by a particular compound or a defect below the surface. Magnetic resonance force microscopy (MRFM) [1,2] is one type of SFM capable of performing magnetic resonance imaging (MRI) [3][4][5][6][7][8][9] with remarkable sensitivity and spatial resolution. The prominent work of single spin detection [10] has demonstrated the potential of MRFM as a tool for observing individual spins, but realizing such performance for routine daily imaging measurements is still challenging.…”

Section: Introductionmentioning

confidence: 99%