Magnetic resonance imaging of muscle and brain in myotonic dystrophy

Damian, Maxwell S.; Bachmann, G. W.; Herrmann, David N.; Dorndorf, W.

doi:10.1007/bf00838438

Cited by 52 publications

(30 citation statements)

References 13 publications

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“…The finding of differential involvement of the flexor digitorum profundus is therefore suggestive of sIBM, but its absence does not exclude the diagnosis. Selective sparing of the rectus femoris with involvement of the vasti and selective involvement of the medial head of the gastrocnemius have also been reported in some cases of myotonic dystrophy 4,8,27 and Becker dystrophy, 9 and are therefore not specific to sIBM. However, in both myotonic dystrophy and Becker dystrophy, there is usually also involvement of other muscles, such as the posterior thigh muscles, adductors, and other calf muscles not usually affected in sIBM.…”

Section: Discussionmentioning

confidence: 91%

Patterns of muscle involvement in inclusion body myositis: Clinical and magnetic resonance imaging study

et al. 2001

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The differential patterns of muscle involvement in the upper and lower limbs in sporadic inclusion body myositis (sIBM) were examined in 18 patients using both quantitative and manual muscle testing as well as magnetic resonance imaging (MRI) in 9 patients. Weakness of the quadriceps femoris and the forearm flexors was present in most patients, but there was considerable variability in the patterns and severity of muscle involvement. MRI disclosed preferential patterns of muscle involvement within functional groups such as the quadriceps femoris, in which there was severe involvement of the vasti with relative sparing of the rectus femoris, and the triceps surae, in which selective involvement of the medial gastrocnemius was common. Involvement of flexor digitorum profundus on MRI was found in only one third of patients. The results emphasize the variability in the clinical phenotype and differential susceptibility of muscles to the disease process in sIBM.

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Section: Discussionmentioning

confidence: 91%

Patterns of muscle involvement in inclusion body myositis: Clinical and magnetic resonance imaging study

et al. 2001

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“…In the thigh muscles, the vastus muscles were damaged most often and rectus femoris least [2,14,15]. On the other hand, in Duchenne type muscular dystrophy, sartorius, gracilis (G), and ST muscles are preserved.…”

Section: Discussionmentioning

confidence: 99%

Muscle MRI in Myotonic Dystrophy Type 1 with Foot Drop

Hamano¹,

Kawamura

Mutoh³

et al. 2010

Eur Neurol

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The purpose of this study was to investigate the relationship of muscle MRI findings and gait disturbance in myotonic dystrophy type 1 (DM1) patients. Thirteen patients with DM1 were evaluated by manual muscle strength test and muscle MRI of the lower limb. All DM1 patients presenting with foot drop showed high intensity signals in the tibialis anterior muscles on T1-weighted imaging (p < 0.001). The patients presenting with gait disturbance showed high intensity signals in the semimembranosus, vastus intermedius and gastrocnemius medialis muscles, too. Disturbance of the gastrocnemius lateralis muscles was mild in all DM1 patients. The patients without gait disturbance showed no abnormalities, especially in tibialis anterior muscles on muscle MRI. Muscle MRI is useful for the detection of pathological muscles in DM1 patients with gait disturbance.

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“…Muscle MRI findings of the lower extremities have previously been reported in DM1 patients [2,[7][8][9][10][11] . DM1 patients showed drop foot and presented with high-intensity areas in the tibialis anterior muscle on T1-weighted imaging [2] .…”

Section: Discussionmentioning

confidence: 99%

“…muscle disturbances of the lower extremities in myotonic dystrophy has been investigated using CT [6] or MRI [2,[7][8][9][10] . However, to our knowledge, only one previous report has evaluated the MRI findings of the upper extremity muscles in DM1 patients [11] .…”

mentioning

confidence: 99%

Muscle MRI of the Upper Extremity in the Myotonic Dystrophy Type 1

Hayashi¹,

Hamano²,

Kawamura³

et al. 2016

Eur Neurol

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Background: The purpose of this study was to explore the relation between muscle MRI findings and weakness of the upper extremity muscles in patients with myotonic dystrophy type 1 (DM1). Methods: Nineteen DM1 patients from 15 families were enrolled in this study. Muscle weakness was evaluated using the modified Medical Research Council scale. Subjects also underwent a genetic study and muscle MRI of the upper extremities. Results: In patients with DM1, the flexor digitorum profundus (FDP), flexor pollicis longus, flexor digitorum superficialis (FDS), extensor pollicis, abductor pollicis longus (APL), lateral head of triceps brachii and infraspinatus (INF) muscles were frequently and severely affected. Muscle strength was significantly correlated with the severity of muscle MRI findings in the FDP, short head of biceps brachii (SBB), and medial head of triceps brachii muscles. Disease duration was correlated significantly with MRI findings in the FDP, FDS, long head of biceps brachii, INF, APL, and SBB muscles. Unexpectedly, the degree of trinucleotide expansion of myotonin protein kinase was not correlated with muscle MRI findings. Conclusion: Muscle MRI of the upper extremity is useful to detect affected muscles in DM1 patients.

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Magnetic resonance imaging of muscle and brain in myotonic dystrophy

Cited by 52 publications

References 13 publications

Patterns of muscle involvement in inclusion body myositis: Clinical and magnetic resonance imaging study

Patterns of muscle involvement in inclusion body myositis: Clinical and magnetic resonance imaging study

Muscle MRI in Myotonic Dystrophy Type 1 with Foot Drop

Muscle MRI of the Upper Extremity in the Myotonic Dystrophy Type 1

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