Magnetic resonance imaging of resting OEF and CMRO2 using a generalized calibration model for hypercapnia and hyperoxia

Gauthier, Claudine; Hoge, Richard D.

doi:10.1016/j.neuroimage.2011.12.056

Cited by 140 publications

(203 citation statements)

References 65 publications

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“…This MLV implementation then resulted in multiple data points to uniquely estimate the two unknowns, CMRO 2 and x nb , within each block. There is substantial amount of noise propagation from the CBF and QSM input to the CMRO 2 output, which can be further reduced using a global CMRO 2 constraint as the regularization in Equation [4].…”

Section: Discussionmentioning

confidence: 99%

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Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Zhang

Cho

Zhou

et al. 2017

Magnetic Resonance in Med

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Purpose: The objective of this study was to demonstrate the feasibility of a cerebral metabolic rate of oxygen (CMRO 2 ) mapping method based on its minimum local variance (MLV) without vascular challenge using quantitative susceptibility mapping (QSM) and cerebral blood flow (CBF). Methods: Three-dimensional multi-echo gradient echo imaging and arterial spin labeling were performed in 11 healthy subjects to calculate QSM and CBF. Minimum local variance was used to compute whole-brain CMRO 2 map from QSM and CBF. The MLV method was compared with a reference method using the caffeine challenge. Their agreement within the cortical gray matter (CGM) was assessed on CMRO 2 and oxygen extraction fraction (OEF) maps at both baseline and challenge states. Results: Mean CMRO 2 (in mmol/100 g/min) obtained in CGM using the caffeine challenge and MLV were 142 6 16.5 and 139 6 14.8 mmol/100 g/min, respectively; the corresponding baseline OEF were 33.0 6 4.0% and 31.8 6 3.2%, respectively. The MLV and caffeine challenge methods showed no statistically significant differences across subjects with small ( < 4%) biases in CMRO 2 and OEF values. Conclusions: Minimum local variance-based CMRO 2 mapping without vascular challenge using QSM and arterial spin labeling is feasible in healthy subjects. Magn Reson Med 79:172-179,

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Section: Discussionmentioning

confidence: 99%

“…l (Eq. [4]) was chosen to be 500. In CGM, the CBF decreased by 16.3 6 7.0 mL/100 g/min (P < .01) after the caffeine challenge.…”

Section: Numerical Simulationmentioning

confidence: 99%

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Zhang

Cho

Zhou

et al. 2017

Magnetic Resonance in Med

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“…Several fMRI methods have been developed to recover baseline CMRO 2 . One of these methods is an extension of calibrated fMRI with both hypercapnia and hyperoxia [14][15][16]. This method has recently been refined using a compartmental BOLD model [66].…”

Section: (D) Linking Microscopic To Macroscopic Parametersmentioning

confidence: 99%

Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon microscopy

Gagnon

Sakadžić

Lesage

et al. 2016

Phil. Trans. R. Soc. B

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One contribution of 15 to a Theo Murphy meeting issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'. LG, 0000-0001-7202-5176Hypercapnic-calibrated fMRI allows the estimation of the relative changes in the cerebral metabolic rate of oxygen (rCMRO 2 ) from combined BOLD and arterial spin labelling measurements during a functional task, and promises to permit more quantitative analyses of brain activity patterns. The estimation relies on a macroscopic model of the BOLD effect that balances oxygen delivery and consumption to predict haemoglobin oxygenation and the BOLD signal. The accuracy of calibrated fMRI approaches has not been firmly established, which is limiting their broader adoption. We use our recently developed microscopic vascular anatomical network model in mice as a ground truth simulator to test the accuracy of macroscopic, lumped-parameter BOLD models. In particular, we investigate the original Davis model and a more recent heuristic simplification. We find that these macroscopic models are inaccurate using the originally defined parameters, but that the accuracy can be significantly improved by redefining the model parameters to take on new values. In particular, we find that the parameter a that relates cerebral blood-volume changes to cerebral blood-flow changes is significantly smaller than typically assumed and that the optimal value changes with magnetic field strength. The results are encouraging in that they support the use of simple BOLD models to quantify BOLD signals, but further work is needed to understand the physiological interpretation of the redefined model parameters. This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.

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“…The gold standard for OEF imaging is positron emission tomography (PET) that involves a sequence of three scans with injection of 15 O or 18 F that is about 46 min and meanwhile the patient is exposed to a radiation dose of 8300MBq (5). PET imaging has several disadvantages that limit its use.…”

Section: Introductionmentioning

confidence: 99%

“…Gauthier and Hoge (2012) (15) and Bulte (2012) (5) where the first group that used these methods. In the following years (2013, 2016), wise et al (16,17) made some improvement to these methods and gained more accurate results for OEF.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Measurement of Oxygen Extraction Fraction (OEF) Using Respiratory Modulated Perfusion MRI

Oghabian

Jafari

2017

Iran J Radiol

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Background: Measurement of oxygen consumption can give useful information of brain functionality in health and disease. To have a better understanding of normal physiology in all conditions (rest or functional tasks), development of accurate brain oxygen mapping is essential. This mapping could also be a great help in managing pathological conditions with disturbance in oxygen supply. One of the most important hemodynamic parameters of the brain is oxygen extraction fraction (OEF). By development of blood oxygen level dependent magnetic resonance imaging (BOLD MRI) in imaging, several methods have been proposed for measuring this parameter. The latest methods are mostly based on hypercapnic and hyperoxic stimulus.

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Magnetic resonance imaging of resting OEF and CMRO2 using a generalized calibration model for hypercapnia and hyperoxia

Cited by 140 publications

References 65 publications

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Quantitative susceptibility mapping‐based cerebral metabolic rate of oxygen mapping with minimum local variance

Validation and optimization of hypercapnic-calibrated fMRI from oxygen-sensitive two-photon microscopy

Quantitative Measurement of Oxygen Extraction Fraction (OEF) Using Respiratory Modulated Perfusion MRI

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