Magnetic resonance imaging of the pancreas in streptozotocin-induced diabetic rats: Gadofluorine P and Gd-DOTA

PEG‐poly(L‐lysine)‐based polymeric micelle MRI contrast agent: Feasibility study of a Gd‐micelle contrast agent for MR lymphography

“…In our study we used gadofluorine P as a control. Gadofluorine P is a daughter product of gadofluorine M (Bayer Schering Pharma, Berlin, Germany; molecular weight, 1528 Da) with improved tolerability . Gadofluorine agents interact strongly with hydrophobic proteins in blood and extracellular tissue, leading to a breakdown of the micelles.…”

“…Gadofluorine P is a daughter product of gadofluorine M (Bayer Schering Pharma, Berlin, Germany; molecular weight, 1528 Da) with improved tolerability. 20 Gadofluorine agents interact strongly with hydrophobic proteins in blood and extracellular tissue, leading to a breakdown of the micelles. In addition, gadofluorine P binds reversibly to plasma proteins and forms semistable, macromolecular gadofluorine-protein complexes after intravenous injection.…”

“…In addition, gadofluorine P binds reversibly to plasma proteins and forms semistable, macromolecular gadofluorine-protein complexes after intravenous injection. Based on these characteristics, gadofluorine P is able to detect atherosclerotic plaques in rabbits, 21 shows high accuracy in the diagnosis of STZ-induced diabetes in rats, 20 and provides satisfactory interstitial MRL images in mice. 15 We performed an interstitial MRL study in healthy and inflamed lymph node mouse models and compared the visualization of the lymphatic system between gadofluorine P and Gd-micelle.…”

“…In addition, gadofluorine P binds reversibly to plasma proteins and forms semistable, macromolecular gadofluorine‐protein complexes after intravenous injection. Based on these characteristics, gadofluorine P is able to detect atherosclerotic plaques in rabbits, shows high accuracy in the diagnosis of STZ‐induced diabetes in rats, and provides satisfactory interstitial MRL images in mice …”