PEG‐poly(L‐lysine)‐based polymeric micelle MRI contrast agent: Feasibility study of a Gd‐micelle contrast agent for MR lymphography

Abstract

1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:238-245.

Double hydrophilic block copolymers self-assemblies in biomedical applications

“…tissues. This result demonstrates the applicability of this DHBC as a diagnostic tool, which was confirmed by a subsequent study using them for magnetic resonance lymphography [80,81].…”

“…We declare that there is no conflict of interest related to this article. Templating agent lysozyme-loaded CaCO3 particles [80,81] FA-PEG PAEP Transfection of plasmid DNA [106] Abbreviations : DNA deoxyribonucleic acid ; FA folate ; PAE-API poly(β-aminoester)-1-(3-aminopropyl)imidazole ; PAEP poly(2-(2-aminoethoxy)ethoxy)phosphazene ; PATMC, poly(5-allyloxytrimethylethylenecarbonate) ; PBYPCOOH poly(phosphotriester) ; PCCL-b-PPIL poly(6-acetoxyl-ε-caprolactone)-b-poly(4-N-piperilactone) ; P(CL-co-CL(COOH)2) poly(ε-caprolactone-co--propane-2,3-dimercaptosuccinic acid-ε-caprolactone) ; P(CL-co-CL (NH2)2) poly(ε-caprolactone-co--propane-2,3dimercapto-4,5-diamino-6-hydroxy-pyrimidine-ε-caprolactone) ; P(CL-co-DCL) poly(ε-caprolactone-co-γ-dimethyl maleamidic acid-ε-caprolactone) ; P(-COOHCL-co-CL) Poly(α-carboxyl-ε-caprolactone-co-ε-caprolactone) ; P(LA-co-MAL) Poly(lactic acid-co-malic acid) ; P(ɤ-NH2-CL) Poly(ɤ-amino-ε-caprolactone) ; PPDOanionic poly(phosphodiester) ; P(-TMA-CL-co-CL) Poly(trimethyl ammonium ε-caprolactone-co-ε-caprolactone) ;…”

Sentinel lymph node detection by combining nonradioactive techniques with contrast agents: State of the art and prospects

“…Other promising contrast agents for MR lymphography and, particularly, for SLN imaging are polymeric micelles and dendrimer-based nanoparticles in complex with Gd [26][27][28][29]. Inflamed lymph nodes can be enhanced even 6 hours after interstitial administration of a Gdmicelle complex [28]. However, the toxicity of such agents has not been tested, and further toxicological studies are needed.…”

Polymerizable Gd(iii) building blocks for the synthesis of high relaxivity macromolecular MRI contrast agents

“…4 An exciting prospect in MRI CA design is the development of macromolecular systems that possess signicantly higher relaxivities. Numerous strategies have been pursued, [5][6][7][8] including the conjugation of one or several Gd(III) complexes to polymers, [9][10][11][12] dendrimers, [13][14][15][16][17][18] micelles [19][20][21][22][23] or nanoparticles, [24][25][26][27][28][29][30][31] or via the non-covalent association with biomolecules (e.g. serum albumin protein) 32,33 or nano-assembled capsules.…”