Magnetic Resonance Imaging Screening for Trilateral Retinoblastoma

Qureshi, Sana; Francis, Jasmine H.; Haque, Sofia; Dunkel, Ira J.; Souweidane, Mark M.; Friedman, Danielle Novetsky; Abramson, David H.

doi:10.1016/j.oret.2019.10.010

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…The detection rate of 2, 3 and 4 additional MRI scans increases to 72%, 87% and 92%, respectively. An issue with performing additional MRI scans is that there will be unclear results requiring follow-up MRI examinations (Qureshi et al 2020). Qureshi et al (2020) showed that 202 MRI scans are required to detect one patient with TRb.…”

Section: Discussionmentioning

confidence: 99%

“…An issue with performing additional MRI scans is that there will be unclear results requiring follow-up MRI examinations (Qureshi et al 2020). Qureshi et al (2020) showed that 202 MRI scans are required to detect one patient with TRb. From our database of TRb patients (de Jong et al 2020), we had similarly estimated that a screening programme for heritable retinoblastoma patients would require 311 scans to detect one TRb, and 776 scans to save a life (de Jong et al 2020).…”

Section: Discussionmentioning

confidence: 99%

“…The updated search gave 3 new article inclusions (Abdelbaki et al 2020;Farouk Sait et al 2020;Qureshi et al 2020) all from the same institution, combined with the two patients presented in Figure 1 and Appendix C. This resulted in the inclusion of 8 new patients and updated information on 4 already included patients (see Appendices B and D).…”

Section: Inclusion Of New Studies and Patientsmentioning

confidence: 99%

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Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta‐analysis

Jong

Shaikh

Gallie

et al. 2021

Acta Ophthalmologica

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To determine the risk of patients with an early diagnosis of heritable retinoblastoma being diagnosed with TRb (or pineoblastoma) asynchronously in a later stage and its effect on screening. Methods:We updated the search (PubMed and Embase) for published literature as performed by our research group in 2014 and 2019. Trilateral retinoblastoma (TRb) patients were eligible for inclusion if identifiable as unique and the age at which TRb was diagnosed was available. The search yielded 97 new studies. Three new studies and eight new patients were included. Combined with 189 patients from the previous meta-analysis, the database included 197 patients. The main outcome was the percentage of asynchronous TRb in patients diagnosed before and after preset age thresholds of 6 and 12 months of age at retinoblastoma diagnosis.Results: Seventy-nine per cent of patients with pineoblastoma are diagnosed with retinoblastoma before the age of 12 months. However, baseline MRI screening at time of retinoblastoma diagnosis fails to detect the later diagnosed pineal TRb in 89% of patients. We modelled that an additional MRI performed at the age of 29 months picks up 53% of pineoblastomas in an asymptomatic phase. The detection rate increased to 72%, 87% and 92%, respectively, with 2, 3 and 4 additional MRIs.Conclusions: An MRI of the brain in heritable retinoblastoma before the age of 12 months misses most pineoblastomas, while retinoblastomas are diagnosed most often before the age of 12 months. Optimally timed additional MRI scans of the brain can increase the asymptomatic detection rate of pineoblastoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Inclusion Of New Studies and Patientsmentioning

confidence: 99%

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Asynchronous pineoblastoma is more likely after early diagnosis of retinoblastoma: a meta‐analysis

Jong

Shaikh

Gallie

et al. 2021

Acta Ophthalmologica

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“…Retinoblastoma (RB) is a common eye malignant tumor and the most common type of tumor in children. According to previous studies, RB shows rapid growth, a high metastatic rate, and poor prognosis (1)(2)(3). With the development of modern technology, the survival rate of RB has increased to over 50% (4,5).…”

Section: ' Introductionmentioning

confidence: 99%

microRNA-144 functions as a diagnostic and prognostic marker for retinoblastoma

Zheng

Zhu

et al. 2020

Clinics

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OBJECTIVES: Retinoblastoma (RB) is a highly malignant eye tumor with a low survival rate and a high metastatic rate. The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. METHODS: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The association between miR-144 expression levels and clinical features were analyzed. Moreover, diagnostic and prognostic values of miR-144 in RB were verified by receiver operating characteristic analysis and Kaplan-Meier survival assays. RESULTS: The expression level of miR-144 was markedly decreased in tumor tissues of RB patients, and the expression level of miR-144 was positively associated with tumor size and metastasis in RB patients. Moreover, miR-144 can distinguish tumor tissues from normal tissues with high specificity and sensitivity, and RB patients with lower miR-144 expression have shorter overall and disease-free survival rates than those with higher miR-144 expression. Alternatively, miR-144 also decreased in the serum of RB patients in comparison with healthy subjects, and miR-144 expression levels in the tissue samples and serum were positively correlated. Furthermore, miR-144 levels in the serum of RB patients sensitively distinguished RB patients from healthy controls. CONCLUSIONS: miR-144 expression was downregulated in serum and tissue samples of RB patients and may function as a diagnostic and prognostic marker for RB.

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