An 18-day-old girl was admitted to the hospital because of a left pneumothorax and cystic changes in the left lung.The infant was a triplet, born by cesarean section to a 36-year-old mother after a 32-week gestation. The Apgar score was 9 at one and five minutes, and the birth weight was 1535 g (40th percentile for gestational age). The patient had mild respiratory distress and required nasal continuous positive airway pressure for two days. The findings on a radiograph of the chest were compatible with mild respiratory distress syndrome. Theophylline was given for periodic apnea and bradycardia, and gavage feedings were begun. The infant was discharged to a nursery at another hospital on the 11th day of life.Two days before admission, tachypnea and tachycardia developed abruptly. The results of laboratory tests are shown in Table 1. The findings on a radiograph of the chest were interpreted as indicating a pneumothorax, although a subsequent review at this hospital showed cystic changes in the left lung and a shift of the mediastinum to the right, without a pneumothorax. A needle aspiration of air was performed, and a chest tube was inserted. Ampicillin and gentamicin were given. A blood culture yielded coagulase-negative staphylococcus, and vancomycin was administered. Two days later, tachypnea recurred, with intercostal retractions, despite a functioning chest tube. Laboratory tests were performed (Tables 1 and 2), and arterial-blood gases measured (Table 3). A chest radiograph (Fig. 1) showed diffuse cystic changes in the left lung, with a mediastinal shift to the right.The infant was transferred to this hospital while T ABLE 1. H EMATOLOGIC L ABORATORY F INDINGS .