2001
DOI: 10.1016/s0360-3016(01)01480-8
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Magnetic resonance spectroscopy of the malignant prostate gland after radiotherapy: a histopathologic study of diagnostic validity

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Cited by 74 publications
(45 citation statements)
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“…When biopsy specimens obtained after external-beam radiation therapy were studied with highresolution MR spectroscopy, Cit was undetectable in almost all benign and malignant biopsy specimens (37). The exact biochemical mechanisms responsible for these "cancer-like" metabolic alterations in benign gland after radiation or hormone treatment are unknown.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…When biopsy specimens obtained after external-beam radiation therapy were studied with highresolution MR spectroscopy, Cit was undetectable in almost all benign and malignant biopsy specimens (37). The exact biochemical mechanisms responsible for these "cancer-like" metabolic alterations in benign gland after radiation or hormone treatment are unknown.…”
Section: Discussionmentioning
confidence: 99%
“…The assessment for cancer was performed by using only three metabolites. Additional metabolites (eg, polyamines), detected in the prostate by using high-resolution one-and two-dimensional spectroscopy ex vivo and single-voxel J-resolved spectroscopy in vivo, could eventually be used to improve the diagnostic accuracy of MR spectroscopy (37,(47)(48)(49).…”
Section: Discussionmentioning
confidence: 99%
“…We have been using with success such approaches in classifying spectra of various tissue specimens, e.g. prostate (22,23), colon (24,25), brain (26), ovary (27), breast (28), thyroid (29), head & neck (30), and esophagus (31). The Statistical Classification Strategy (SCS) is the consequence of this series of studies.…”
Section: Introductionmentioning
confidence: 99%
“…3 MRS signals from different chemical groups can be correlated to the biology of the cell. In particular, lipid metabolism can be examined by 1 H MRS through the identification and analysis of many individual metabolites in vitro, 4-6 ex vivo [7][8] and in vivo. 9,10 Among lipid metabolites, phosphocholine (PC), glycerophosphocholine (GPC) and choline (Cho) are often studied, being involved in the synthetic and catabolic pathways of the main phospholipids.…”
Section: Introductionmentioning
confidence: 99%