Magnetic-silk/polyethyleneimine core-shell nanoparticles for targeted gene delivery into human breast cancer cells

Song, Wenxing; Gregory, David A.; Al-Janabi, Haider; Muthana, Munitta; Cai, Zhiqiang; Zhao, Xiubo

doi:10.1016/j.ijpharm.2018.11.030

Cited by 50 publications

(23 citation statements)

References 65 publications

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“…Recently, fibroin nanoparticles have also been highlighted for their versatility, non-toxicity, high transfection efficiency, and DNase resistance properties. Song et al manufactured a c-myc anti-sense oligo deoxyneucleotide-containing fibroin-PEI NP, with or without the addition of magnetic NP, for targeted delivery to MDA-MB-231 breast cancer cell lines [ 8 ]. The particle size and zeta potential were controlled by varying the amount of fibrin.…”

Section: Types Of Proteins Used To Produce Protein Nanoparticlesmentioning

confidence: 99%

“…Thus, drug delivery systems are becoming increasingly important. Among them, several nanomaterials, such as liposomes [ 2 , 3 ], polymers [ 4 , 5 ], dendrimers [ 6 , 7 ], and magnetic nanoparticles [ 8 , 9 ], are used as carriers for drug delivery. The transport of insoluble drugs via nanoparticles is improving because of their small particle size, which quickly dissolves in the bloodstream and can reach a cell or tissue-specific target.…”

Section: Introductionmentioning

confidence: 99%

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Protein-Based Nanoparticles as Drug Delivery Systems

et al. 2020

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Nanoparticles have been extensively used as carriers for the delivery of chemicals and biomolecular drugs, such as anticancer drugs and therapeutic proteins. Natural biomolecules, such as proteins, are an attractive alternative to synthetic polymers commonly used in nanoparticle formulation because of their safety. In general, protein nanoparticles offer many advantages, such as biocompatibility and biodegradability. Moreover, the preparation of protein nanoparticles and the corresponding encapsulation process involved mild conditions without the use of toxic chemicals or organic solvents. Protein nanoparticles can be generated using proteins, such as fibroins, albumin, gelatin, gliadine, legumin, 30Kc19, lipoprotein, and ferritin proteins, and are prepared through emulsion, electrospray, and desolvation methods. This review introduces the proteins used and methods used in generating protein nanoparticles and compares the corresponding advantages and disadvantages of each.

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Section: Types Of Proteins Used To Produce Protein Nanoparticlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protein-Based Nanoparticles as Drug Delivery Systems

et al. 2020

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“…Recently, Song et al fabricated the fibroin-PEI NPs with and without the addition of magnetic NPs, using the salting out method, for the targeted delivery of c-myc antisense oligodeoxynucleotides into the MDA-MB-231 breast cancer cell line (Song et al, 2019). The particle size and zeta potential were controllable by varying the amount of fibroin.…”

Section: Gene Deliverymentioning

confidence: 99%

“…Demonstrating less cytotoxicity than the PEI NPs only, both fibroin-PEI NPs, with and without magnetic NPs, could deliver the encapsulated genetic material into MDA-MB-231 cells successfully. By utilizing magnetofection, the fibroin-PEI combined with magnetic NPs showed significantly enhanced uptake into the cells (over 70%) within 20 min, compared to the same carriers via non-magnetofection (Song et al, 2019).…”

Section: Gene Deliverymentioning

confidence: 99%

Fibroin nanoparticles: a promising drug delivery system

2020

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Fibroin is a dominant silk protein that possesses ideal properties as a biomaterial for drug delivery. Recently, the development of fibroin nanoparticles (FNPs) for various biomedical applications has been extensively studied. Due to their versatility and chemical modifiability, FNPs can encapsulate different types of therapeutic compounds, including small and big molecules, proteins, enzymes, vaccines, and genetic materials. Moreover, FNPs are able to be administered both parenterally and non-parenterally. This review summaries basic information on the silk and fibroin origin and characteristics, followed by the up-to-date data on the FNPs preparation and characterization methods. In addition, their medical applications as a drug delivery system are in-depth explored based on several administrative routes of parenteral, oral, transdermal, ocular, orthopedic, and respiratory. Finally, the challenges and suggested solutions, as well as the future outlooks of these systems are discussed.

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“…Thus current literature indicates that silk-based composite materials can be used to form excellent tuneable scaffold materials for cardiac repair with low immunological responses, good cell adhesion, and proliferation, as well as superior mechanical properties (234,242,243). Silk as a biomaterial gives the opportunity to create a variety of materials including fibers (237), foams (241), hydrogels (231), nanoparticles (245), films (243), and 3D printed structures (246,247). It also has tuneable degradation rates as well as the potential for gene and drug delivery in the created constructs.…”

Section: Silk As a Scaffold Biomaterials For Cardiac Tissue Repairmentioning

confidence: 99%

Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution

Majid

Fricker

Gregory

et al. 2020

Front. Cardiovasc. Med.

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Cardiovascular diseases (CVD) constitute a major fraction of the current major global diseases and lead to about 30% of the deaths, i.e., 17.9 million deaths per year. CVD include coronary artery disease (CAD), myocardial infarction (MI), arrhythmias, heart failure, heart valve diseases, congenital heart disease, and cardiomyopathy. Cardiac Tissue Engineering (CTE) aims to address these conditions, the overall goal being the efficient regeneration of diseased cardiac tissue using an ideal combination of biomaterials and cells. Various cells have thus far been utilized in pre-clinical studies for CTE. These include adult stem cell populations (mesenchymal stem cells) and pluripotent stem cells (including autologous human induced pluripotent stem cells or allogenic human embryonic stem cells) with the latter undergoing differentiation to form functional cardiac cells. The ideal biomaterial for cardiac tissue engineering needs to have suitable material properties with the ability to support efficient attachment, growth, and differentiation of the cardiac cells, leading to the formation of functional cardiac tissue. In this review, we have focused on the use of biomaterials of natural origin for CTE. Natural biomaterials are generally known to be highly biocompatible and in addition are sustainable in nature. We have focused on those that have been widely explored in CTE and describe the original work and the current state of art. These include fibrinogen (in the context of Engineered Heart Tissue, EHT), collagen, alginate, silk, and Polyhydroxyalkanoates (PHAs). Amongst these, fibrinogen, collagen, alginate, and silk are isolated from natural sources whereas PHAs are produced via bacterial fermentation. Overall, these biomaterials have proven to be highly promising, displaying robust biocompatibility and, when combined with cells, an ability to enhance post-MI cardiac function in pre-clinical models. As such, CTE has great potential for future clinical solutions and hence can lead to a considerable reduction in mortality rates due to CVD.

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Magnetic-silk/polyethyleneimine core-shell nanoparticles for targeted gene delivery into human breast cancer cells

Cited by 50 publications

References 65 publications

Protein-Based Nanoparticles as Drug Delivery Systems

Protein-Based Nanoparticles as Drug Delivery Systems

Fibroin nanoparticles: a promising drug delivery system

Natural Biomaterials for Cardiac Tissue Engineering: A Highly Biocompatible Solution

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