Magnetic Targeting Enhanced Theranostic Strategy Based on Multimodal Imaging for Selective Ablation of Cancer

Abstract

The booming development of nanomedicine offers great opportunities for cancer diagnostics and therapeutics. Herein, a magnetic targeting-enhanced cancer theranostic strategy using a multifunctional magnetic-plasmonic nanoagent is developed, and a highly effective in vivo tumor photothermal therapy, which is carefully planed based on magnetic resonance (MR)/photoacoustic (PA) multimodal imaging, is realized. By applying an external magnetic fi eld (MF) focused on the targeted tumor, a magnetic targeting mediated enhanced permeability and retention (MT-EPR) effect is observed. While MR scanning provides tumor localization and reveals time-dependent tumor homing of nanoparticles for therapeutic planning, photoacoustic imaging with higher spatial resolution allows noninvasive fi ne tumor margin delineation and vivid visualization of three dimensional distributions of theranostic nanoparticles inside the tumor. Utilizing the near-infrared (NIR) plasmonic absorbance of those nanoparticles, selective photothermal tumor ablation, whose effi cacy is predicted by real-time infrared thermal imaging intra-therapeutically, is carried out and then monitored by MR imaging for post-treatment prognosis. Overall, this study illustrates the concept of imaging-guided MF-targeted photothermal therapy based on a multifunctional nano-agent, aiming at optimizing therapeutic planning to achieve the most effi cient cancer therapy.

Magnetic Field‐Enhanced Photothermal Ablation of Tumor Sentinel Lymph Nodes to Inhibit Cancer Metastasis

“…The development of nanomedicine has brought great opportunities to the fight against cancer . Many novel tumor targeting and cancer treatment approaches, not only relying on conventional cancer molecular biology strategies, but also involving physical forces (e.g., magnetic field, optical light) to target and destruct tumors, have been proposed with the help of nanotechnology . In particular, the development of nanomedicine approaches to treat cancer metastasis has received significant attention in these years .…”

Fast assembling microarrays of superparamagnetic Fe3O4@Au nanoparticle clusters as reproducible substrates for surface-enhanced Raman scattering

“…42 The surface of Fe 3 O 4 nanoparticles was modified by dopamine (DA) molecules via complexation of iron ions and phenolic hydroxyl groups, thus making it hydrophilic and positivelycharged. 42 The surface of Fe 3 O 4 nanoparticles was modified by dopamine (DA) molecules via complexation of iron ions and phenolic hydroxyl groups, thus making it hydrophilic and positivelycharged.…”

“…42 The surface of Fe 3 O 4 nanoparticles was modified by dopamine (DA) molecules via complexation of iron ions and phenolic hydroxyl groups, thus making it hydrophilic and positivelycharged. 42 This procedure created Fe 3 O 4 nanoparticles enclosed by a dense layer of protruding Au antenna nanostructures. 42 This procedure created Fe 3 O 4 nanoparticles enclosed by a dense layer of protruding Au antenna nanostructures.…”

Recent Advances in Functional‐Polymer‐Decorated Transition‐Metal Nanomaterials for Bioimaging and Cancer Therapy

“…d) Quantification of magnetic resonance and photoacoustic signals incubated with IONC@Au‐PEG for 24 h. Reproduced with permission from Ref. . Copyright Wiley‐VCH, 2014.…”