Magnetic Two-Way Valves for Paper-Based Capillary-Driven Microfluidic Devices

Fratzl, Mario; Chang, Boyce S.; Oyola‐Reynoso, Stephanie; Blaire, Guillaume; Delshadi, Sarah; Devillers, Thibaut; Ward, Thomas; Dempsey, Nora; Bloch, Jean‐Francis; Thuo, Martin M.

doi:10.1021/acsomega.7b01839

Cited by 42 publications

(31 citation statements)

References 61 publications

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“…Mechanically actuated valves have also been developed such as layered push-to-contact paper valves 12 and compressive sponge actuators 6 but these are irreversible once actuated. Other μPAD valve modalities rely on external magnetic fields 13 , 14 or local heating via thin film resistors 15 . However, the complexity and requirement for electronic equipment may hinder the applicability of these formats, especially in low-resource settings or with untrained operators.…”

Section: Introductionmentioning

confidence: 99%

Hybrid 3D printed-paper microfluidics

Zargaryan

Farhoudi

Haworth

et al. 2020

Sci Rep

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3D printed and paper-based microfluidics are promising formats for applications that require portable miniaturized fluid handling such as point-of-care testing. These two formats deployed in isolation, however, have inherent limitations that hamper their capabilities and versatility. Here, we present the convergence of 3D printed and paper formats into hybrid devices that overcome many of these limitations, while capitalizing on their respective strengths. Hybrid channels were fabricated with no specialized equipment except a commercial 3D printer. Finger-operated reservoirs and valves capable of fully-reversible dispensation and actuation were designed for intuitive operation without equipment or training. Components were then integrated into a versatile multicomponent device capable of dynamic fluid pathing. These results are an early demonstration of how 3D printed and paper microfluidics can be hybridized into versatile lab-on-chip devices.

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Section: Introductionmentioning

confidence: 99%

Hybrid 3D printed-paper microfluidics

Zargaryan

Farhoudi

Haworth

et al. 2020

Sci Rep

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“…Active microfluidic liquid flow control employing diverse forms of external actuations, including hydrogel‐based valves, magnetic valves, and electrowetting valves, based on diffusion, magnetic, and electrical actuation, respectively, has been implemented. However, designs equipped with active µ‐valves have several practical weaknesses hindering large‐scale applications in wearable microfluidic sensors.…”

Section: Liquid Flow Control Of Wearable Microfluidic Sensorsmentioning

confidence: 99%

Advanced Wearable Microfluidic Sensors for Healthcare Monitoring

Cao

et al. 2019

Small

141

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Wearable flexible sensors based on integrated microfluidic networks with multiplex analysis capability are emerging as a new paradigm to assess human health status and show great potential in application fields such as clinical medicine and athletic monitoring. Well‐designed microfluidic sensors can be attached to the skin surface to acquire various pieces of physiological information with high precision, such as sweat loss, information regarding metabolites, and electrolyte balance. Herein, the recent progress of wearable microfluidic sensors for applications in healthcare monitoring is summarized, including analysis principles and microfabrication methods. Finally, the challenges and opportunities for wearable microfluidic sensors in practical applications are discussed.

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“…The advantage of this approach is that it can perform various functions (Off to On, On to Off, and diversion switch) ( Figure 11A). An electromagnetic valve on paper-based analytical devices has also been studied [105,106]. The cantilever valve is made by applying ferromagnetic nanoparticles.…”

Section: Mechanical Actuation-based Active Valvesmentioning

confidence: 99%

“…In this way, the flow of fluid can be automatically controlled ( Figure 11B). This valve can be operated several times and is programmable [106]. Rotational valve (hollow rivet) Switching (ON) ELISA (carcino-embryonic antigen; CEA) [102] Rotational valve (comb binding) Switching (ON) Colorimetric-enzymatic assay (Fe 2+ and nitrite) [103] Rotational valve (circular disk) Switching (ON) Fluorescence-based molecular-imprinting detection (4-nitrophenol and 2,4,6-trinitrophenol) [39] Rotational valves on paper-based analytical devices have been implemented using rotatable disk-type packaging [101], hollow rivets [102], comb binding [103], and rotational paper-based microfluidic chips [39] as ways to bridge separated paper channels.…”

Section: Mechanical Actuation-based Active Valvesmentioning

confidence: 99%

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Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays

Kim¹,

Hahn

Kim

2020

Micromachines

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Microfluidic paper-based analytical devices (μPADs) have been suggested as alternatives for developing countries with suboptimal medical conditions because of their low diagnostic cost, high portability, and disposable characteristics. Recently, paper-based diagnostic devices enabling multi-step assays have been drawing attention, as they allow complicated tests, such as enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR), which were previously only conducted in the laboratory, to be performed on-site. In addition, user convenience and price of paper-based diagnostic devices are other competitive points over other point-of-care testing (POCT) devices, which are more critical in developing countries. Fluid manipulation technologies in paper play a key role in realizing multi-step assays via μPADs, and the expansion of biochemical applications will provide developing countries with more medical benefits. Therefore, we herein aimed to investigate recent fluid manipulation technologies utilized in paper-based devices and to introduce various approaches adopting several principles to control fluids on papers. Fluid manipulation technologies are classified into passive and active methods. While passive valves are structurally simple and easy to fabricate, they are difficult to control in terms of flow at a specific spatiotemporal condition. On the contrary, active valves are more complicated and mostly require external systems, but they provide much freedom of fluid manipulation and programmable operation. Both technologies have been revolutionized in the way to compensate for their limitations, and their advances will lead to improved performance of μPADs, increasing the level of healthcare around the world.

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Magnetic Two-Way Valves for Paper-Based Capillary-Driven Microfluidic Devices

Cited by 42 publications

References 61 publications

Hybrid 3D printed-paper microfluidics

Hybrid 3D printed-paper microfluidics

Advanced Wearable Microfluidic Sensors for Healthcare Monitoring

Recent Advances of Fluid Manipulation Technologies in Microfluidic Paper-Based Analytical Devices (μPADs) toward Multi-Step Assays

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