2020
DOI: 10.1186/s13065-019-0657-9
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Magnetic γFe2O3@Sh@Cu2O: an efficient solid-phase catalyst for reducing agent and base-free click synthesis of 1,4-disubstituted-1,2,3-triazoles

Abstract: A hybrid magnetic material γFe 2 O 3 @Sh@cu 2 O was easily prepared from Shilajit (Sh) decorated Fe 3 O 4 and copper acetate. The prepared magnetic hybrid material was fully characterized using different analysis, including Fourier transform infrared (FT-IR), X-ray diffraction (XRD), inductively coupled plasma (ICP), scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM) thermal gravimetric analysis (TGA) and B… Show more

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Cited by 50 publications
(26 citation statements)
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“…With respect to their antioxidant activity, flavonoids are believed to prevent diseases that are related to OS via the direct scavenging of reactive oxygen species (ROS) through the donation of a hydrogen atom, activation of antioxidant enzymes, metal (such as iron and copper)-chelating activity, and alleviation of oxidative stress that is caused by nitric oxide (NO) [ 1 , 8 , 9 , 10 , 11 ]. Antioxidant activity, though, cannot be the sole explanation for the in vivo cellular effects of flavonoids’, since antioxidant activity is expressed at flavonoid concentrations that are above 10 μM, but their concentration in the circulation does not exceed 2 μM [ 12 ].…”
Section: Biological Activities Of Flavonoidsmentioning
confidence: 99%
See 1 more Smart Citation
“…With respect to their antioxidant activity, flavonoids are believed to prevent diseases that are related to OS via the direct scavenging of reactive oxygen species (ROS) through the donation of a hydrogen atom, activation of antioxidant enzymes, metal (such as iron and copper)-chelating activity, and alleviation of oxidative stress that is caused by nitric oxide (NO) [ 1 , 8 , 9 , 10 , 11 ]. Antioxidant activity, though, cannot be the sole explanation for the in vivo cellular effects of flavonoids’, since antioxidant activity is expressed at flavonoid concentrations that are above 10 μM, but their concentration in the circulation does not exceed 2 μM [ 12 ].…”
Section: Biological Activities Of Flavonoidsmentioning
confidence: 99%
“…Several mechanisms of action have been proposed to explain flavonoids’ anti-inflammatory activity in vivo, such as antioxidant activity and the modulation of the production of proinflammatory cytokines and gene expression [ 11 ]. Interestingly, flavonoids affect the inflammatory process not only by reducing the expression of cytokines and other related inflammatory markers, but also by interacting with proteins that are related to inflammation.…”
Section: Flavonoids Attenuate Human Diseases Via Direct Interactiomentioning
confidence: 99%
“…Cells were then incubated with different leaf fraction concentrations ranging from 0.25–10 mg/ml of R. rothschildianus for 24 h. Cell viability was assessed with the CellTilter 96® Aqueous One Solution Cell Proliferation (MTS) Assay according to the manufacturer’s instructions (Promega Corporation, Madison, WI). Briefly, at the end of the treatment, 20 μl MTS solution per 100 μl media was added to each well and incubated at 37 °C for 2 h. Absorbances were measured at 490 nm [ 27 , 28 ].…”
Section: Methodsmentioning
confidence: 99%
“…The reactive oxygen radicals as hydrogen peroxide (H 2 O 2 ), superoxide anion radical (O 2 − ), hydroxyl radical (HO − ), peroxynitrite (ONOO − ), and nitric oxide (NO) play important roles in both physiological and pathological conditions, increasing in some diseases, such as cancer, and inflammation. The in vivo detection is difficult due to a short half-life, but different kinds of sensors have been also reported [ 212 ]. Genetically encoded sensors for ROS, in particular for H 2 O 2 (namely HyPer) consist of a circularly permuted yellow fluorescence protein (cpYFP) inserted into the regulatory domain of the Escherichia coli hydrogen peroxide-binding protein (OxyR).…”
Section: Fluorescence-based Biosensorsmentioning
confidence: 99%