Magnetically Actuated Cell‐Robot System: Precise Control, Manipulation, and Multimode Conversion (Small 15/2022)

Dai, Yuguo; Jia, Lina; Wang, Luyao; Sun, Hongyan; Ji, Yiming; Wang, Chutian; Li, Song; Liang, Shuquan; Chen, Dixiao; Feng, Yujun; Bai, Xue; Zhang, Deyuan; Arai, Fumihito; Chen, Huawei; Feng, Lin

doi:10.1002/smll.202270076

Cited by 3 publications

(3 citation statements)

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“…Magnetic robots can be actuated remotely, precisely, and flexibly using an external magnetic field. [8] Because the magnetic field has sufficient penetration depth for the human body and is considered safe for biological cells at low intensity, it has considerable potential for minimally invasive medical applications. [9][10][11][12] Currently, scientists have accomplished their goal of delivering millirobots to several organs and tissues with cavities, such as the gastrointestinal tract and gallbladder.…”

Section: Introductionmentioning

confidence: 99%

Catheter‐Assisted Bioinspired Adhesive Magnetic Soft Millirobot for Drug Delivery

Hu,

Zhou,

et al. 2023

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Soft millirobots have evolved into various therapeutic applications in the medical field, including for vascular dredging, cell transportation, and drug delivery, owing to adaptability to their surroundings. However, most soft millirobots cannot quickly enter, retrieve, and maintain operations in their original locations after removing the external actuation field. This study introduces a soft magnetic millirobot for targeted medicine delivery that can be transported into the body through a catheter and anchored to the tissues. The millirobot has a bilayer adhesive body with a mussel‐inspired hydrogel layer and an octopus‐inspired magnetic structural layer. It completes entry and retrieval with the assistance of a medical catheter based on the difference between the adhesion of the hydrogel layer in air and water. The millirobot can operate in multiple modes of motion under external magnetic fields and underwater tissue adhesion after self‐unfolding with the structural layer. The adaptability and recyclability of the millirobots are demonstrated using a stomach model. Combined with ultrasound (US) imaging, operational feasibility within organisms is shown in isolated small intestines. In addition, a highly efficient targeted drug delivery is confirmed using a fluorescence imaging system. Therefore, the proposed soft magnetic millirobots have significant potential for medical applications.

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Section: Introductionmentioning

confidence: 99%

Catheter‐Assisted Bioinspired Adhesive Magnetic Soft Millirobot for Drug Delivery

Hu,

Zhou,

et al. 2023

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“…The precise and robust motion control of MXBOTs is essential for their utilization as a platform for targeted delivery. 42 Therefore, we characterized the magnetic properties of Fe 3 O 4 and MXBOTs by using a vibrating sample magnetometer (VSM). As shown in Figure S4, Fe 3 O 4 exhibits significant paramagnetism with a high saturation magnetization of 63.4 emu/g.…”

mentioning

confidence: 99%

“…The precise and robust motion control of MXBOTs is essential for their utilization as a platform for targeted delivery . Therefore, we characterized the magnetic properties of Fe 3 O 4 and MXBOTs by using a vibrating sample magnetometer (VSM).…”

mentioning

confidence: 99%

MXBOTs: Biodegradable Ti₃C₂ MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy

Yang,

Xie,

Jiang

et al. 2024

ACS Materials Lett.

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Functions such as biocompatibility, degradability, therapeutics, and imaging are critical for use of microrobots in clinical scenarios; however, incorporation of these functions into a single microrobotic entity is still challenging. Herein, we report multifunctional Ti 3 C 2 MXene-based magnetically actuated microrobots (MXBOTs), which are prepared by sequentially electrostatic coating of Ti 3 C 2 nanosheets and Fe 3 O 4 nanoparticles on the surface of biodegradable gelatin methacryloyl (GelMA)-based helical microstructures. These MXBOTs can move along predefined paths under a rotating magnetic field. The incorporation of Ti 3 C 2 nanosheets provides MXBOTs with an advantageous photothermal effect and photoacoustic (PA) imaging capability. Additionally, MXBOTs can be loaded with fluorescent molecules, enabling fluorescence imaging. After loading the chemotherapeutic drug DOX, the MXBOTs@DOX were able to accelerate the release of DOX under the stimulation of temperature and acidic pH. This work presents a viable approach for developing biodegradable and functional microrobots for targeted delivery and synergistic chemo-photothermal therapy.

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Magnetically Controlled Millipede Inspired Soft Robot for Releasing Drugs on Target Area in Stomach

Yang,

Wang,

et al. 2024

IEEE Robot. Autom. Lett.

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Magnetically Actuated Cell‐Robot System: Precise Control, Manipulation, and Multimode Conversion (Small 15/2022)

Cited by 3 publications

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Catheter‐Assisted Bioinspired Adhesive Magnetic Soft Millirobot for Drug Delivery

Catheter‐Assisted Bioinspired Adhesive Magnetic Soft Millirobot for Drug Delivery

MXBOTs: Biodegradable Ti₃C₂ MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy

Magnetically Controlled Millipede Inspired Soft Robot for Releasing Drugs on Target Area in Stomach

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Magnetically Actuated Cell‐Robot System: Precise Control, Manipulation, and Multimode Conversion (Small 15/2022)

Cited by 3 publications

References 0 publications

Catheter‐Assisted Bioinspired Adhesive Magnetic Soft Millirobot for Drug Delivery

Catheter‐Assisted Bioinspired Adhesive Magnetic Soft Millirobot for Drug Delivery

MXBOTs: Biodegradable Ti3C2 MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy

Magnetically Controlled Millipede Inspired Soft Robot for Releasing Drugs on Target Area in Stomach

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MXBOTs: Biodegradable Ti₃C₂ MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy