Magnetically responsive nanofibrous ceramic scaffolds for on-demand motion and drug delivery

Zhang, Yonggang; Li, Jiaping; Habibović, Pamela

doi:10.1016/j.bioactmat.2022.02.028

Cited by 24 publications

(26 citation statements)

References 57 publications

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“…On the other hand, previously reported magnetoactive scaffolds are often based on hydrogels or ceramics and require much higher magnetic field intensities to achieve deformation. For example, a hydroxyapatite sponge was reported to undergo contraction of up to 25% in close proximity to an electromagnet with 200-kg strength [25] . Additionally, Spangenberg et al reported that 3D-printed reticulated scaffolds based on ION-loaded alginate/methyl cellulose hydrogels were capable of contraction up to 4%, which occurred due to filament collapse under a magnetic field intensity of up to 200 mT [52] .…”

Section: Mechanical Behavior and Magnetic Actuation Of Pcl And Pcl/rg...mentioning

confidence: 99%

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Servin

Dahri

Meneses

et al. 2023

Preprint

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Tunable culture platforms that guide cellular organization and mechanically stimulate skeletal muscle development are still unavailable due to limitations in biocompatibility and actuation triggered without contact. This study reports the rational design and fabrication of magneto-active microfiber meshes with controlled hexagonal microstructures via melt electrowriting (MEW) of a thermoplastic/graphene/iron oxide composite. In situ deposition of iron oxide nanoparticles on oxidized graphene yielded homogeneously dispersed magnetic particles with sizes above 0.5 micrometer and low aspect ratio, preventing cellular internalization and toxicity. With these fillers, homogeneous magnetic composites with very high magnetic filler content (up to 10 wt.%) were obtained and successfully processed in a solvent-free manner for the first time. MEW of magnetic composites enabled the skeletal muscle-inspired design of hexagonal scaffolds with tunable fiber diameter, reconfigurable modularity, and zonal distribution of magneto-active and nonactive material. Importantly, the hexagonal microstructures displayed elastic deformability under tension, mitigating the mechanical limitations due to high filler content. External magnetic fields below 300 mT were sufficient to trigger out-of-plane reversible deformation leading to effective end-to-end length decrease up to 17%. Moreover, C2C12 myoblast culture on 3D Matrigel/collagen/MEW scaffolds showed that the presence of magnetic particles in the scaffolds did not significantly affect viability after 8 days with respect to scaffolds without magnetic filler. Importantly, in vitro culture demonstrated that myoblasts underwent differentiation at similar rates regardless of the presence of magnetic filler. Overall, these innovative microfiber scaffolds were proven as a magnetically deformable platform suitable for dynamic culture of skeletal muscle with potential for in vitro disease modeling.

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Section: Mechanical Behavior and Magnetic Actuation Of Pcl And Pcl/rg...mentioning

confidence: 99%

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Servin

Dahri

Meneses

et al. 2023

Preprint

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“…A variety of intelligent hydrogels, such as photo‐responsive hydrogels, thermal responsive hydrogels, pH responsive hydrogels, etc., have been developed and shown remarkable biomedical values 25–30 . By combining smart hydrogel systems with fabrication strategies like microfluidic, 3D printing, and electrostatic spinning, the fabrication of responsive hydrogel microfibers could be easily realized, which has achieved significant advances in biomedical engineering applications, including drug delivery, biosensors, clinical treatment, etc., according to the relevant literatures 31–36 …”

Section: Introductionmentioning

confidence: 99%

“…[25][26][27][28][29][30] By combining smart hydrogel systems with fabrication strategies like microfluidic, 3D printing, and electrostatic spinning, the fabrication of responsive hydrogel microfibers could be easily realized, which has achieved significant advances in biomedical engineering applications, including drug delivery, biosensors, clinical treatment, etc., according to the relevant literatures. [31][32][33][34][35][36] In this review, we provide a comprehensive summarization of the latest relevant research studies on the responsive hydrogel microfibers and their promising applications in biomedical engineering. To begin, we introduce the common fabrication strategy of responsive hydrogel microfibers.…”

mentioning

confidence: 99%

Responsive hydrogel microfibers for biomedical engineering

et al. 2022

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Responsive hydrogel microfibers can realize multiple controllable changes in shapes or properties under the stimulation of the surrounding environment, and are called as intelligent biomaterials. Recently, these responsive hydrogel microfibers have been proved to possess significant biomedical values, and remarkable progress has been achieved in biomedical engineering applications, including drug delivery, biosensors and clinical therapy, etc. In this review, the latest research progress and application prospects of responsive hydrogel microfibers in biomedical engineering are summarized. We first introduce the common preparation strategies of responsive hydrogel microfibers. Subsequently, the response characteristics and the biomedical applications of these materials are discussed. Finally, the present opportunities and challenges as well as the prospects for future development are critically analyzed.

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“…In recent years, hydroxyapatite-based materials have been successfully used for the adsorption of BPA in the form of nanowire membranes 16 and dried foam 17 have been used for. In addition, HAp-based materials have been studied as drug deliveries, 18 heterogeneous catalysis, 19 and photoluminescent materials. 20 Hydroxyapatite (HAp), Ca 10 (PO 4 ) 6 (OH) 2 ) is the main inorganic component of bones and teeth; thus, hydroxyapatite-based materials are mainly used in the medical field to produce synthetic bone grafts.…”

Section: Introductionmentioning

confidence: 99%

Zinc-doped hydroxyapatite: an UVA light photocatalyst for the removal of bisphenol A

et al. 2022

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Magnetically responsive nanofibrous ceramic scaffolds for on-demand motion and drug delivery

Cited by 24 publications

References 57 publications

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

3D printed magneto-active microfiber scaffolds for remote stimulation of 3Din vitroskeletal muscle models

Responsive hydrogel microfibers for biomedical engineering

Zinc-doped hydroxyapatite: an UVA light photocatalyst for the removal of bisphenol A

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