Magnetically triggered nanovehicles for controlled drug release as a colorectal cancer therapy

Kuo, Cheng-Tzu; Liu, Ting Yu; Chan, Tzu Yi; Tsai, Sung Chen; Hardiansyah, Andri; Huang, Li; Yang, Ming; Lu, Ruey Hwa; Jiang, Jeng Kai; Yang, Chung‐May; Lin, Chi; Chiu, Wen‐Yen

doi:10.1016/j.colsurfb.2015.11.008

Cited by 37 publications

(31 citation statements)

References 46 publications

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“…Nanotechnology and nanomedicine offer new opportunity for cancer treatment. In this respect development of nanoparticles with various feature and functions along with the innovation of the cancer treatment methodology has been conducted experimentally in in vitro and in vivo [1, 2]. …”

Section: Introductionmentioning

confidence: 99%

“…Specifically, through the guidance of external magnetic field, magnetic liposomes could be directed into the specific area of tumor cells, then promote another specific function, including drug release [3, 16, 20, 21] and killing the cancerous cells [3, 13, 16, 22, 23]. High-frequency magnetic field (HFMF) has been developed as a system to assist the magnetic-based nanoparticles developed the specific function based on the interaction between the magnetic-based nanoparticles and HFMF exposure [1–3, 24, 25]. …”

Section: Introductionmentioning

confidence: 99%

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Hydrophobic Drug-Loaded PEGylated Magnetic Liposomes for Drug-Controlled Release

et al. 2017

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Less targeted and limited solubility of hydrophobic-based drug are one of the serious obstacles in drug delivery system. Thus, new strategies to enhance the solubility of hydrophobic drug and controlled release behaviors would be developed. Herein, curcumin, a model of hydrophobic drug, has been loaded into PEGylated magnetic liposomes as a drug carrier platform for drug controlled release system. Inductive magnetic heating (hyperthermia)-stimulated drug release, in vitro cellular cytotoxicity assay of curcumin-loaded PEGylated magnetic liposomes and cellular internalization-induced by magnetic guidance would be investigated. The resultant of drug carriers could disperse homogeneously in aqueous solution, showing a superparamagnetic characteristic and could inductive magnetic heating with external high-frequency magnetic field (HFMF). In vitro curcumin release studies confirmed that the drug carriers exhibited no significant release at 37 °C, whereas exhibited rapid releasing at 45 °C. However, it would display enormous (three times higher) curcumin releasing under the HFMF exposure, compared with that without HFMF exposure at 45 °C. In vitro cytotoxicity test shows that curcumin-loaded PEGylated magnetic liposomes could efficiently kill MCF-7 cells in parallel with increasing curcumin concentration. Fluorescence microscopy observed that these drug carriers could internalize efficiently into the cellular compartment of MCF-7 cells. Thus, it would be anticipated that the novel hydrophobic drug-loaded PEGylated magnetic liposomes in combination with inductive magnetic heating are promising to apply in the combination of chemotherapy and thermotherapy for cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrophobic Drug-Loaded PEGylated Magnetic Liposomes for Drug-Controlled Release

et al. 2017

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“…41 Kuo et al 42 fabricated smart multifunctional magnetic nanovehicles encapsulating anticancer drugs and an antibody-targeting peptide AP-1 (MPVA-AP1). 42 In this study, the magnetic nanovehicles with consistent sizes and dispersed in aqueous solution displayed good hemocompatibility and no toxicity toward L929 fibroblasts, which showed their potential for applications in therapeutics. Using a simple synthesis method, that is, the double-emulsion method, the researchers observed considerable encapsulation of both hydrophilic and hydrophobic lowmolecular-weight drugs and protein-like drugs.…”

Section: Applications Of Iron Oxide Nanocrystalsmentioning

confidence: 61%

“…Thus, smart magnetic nanovehicles, such as MPVA-AP1, have significant potential for targeted doses and accurate controlled release in anticancer applications. 42 Esmaelbeygi et al 43 demonstrated the effectiveness of polylactide-co-glycolic acid (PLGA) NPs as a 5-fluorouracil (5-FU) carrier with and without an iron oxide core and hyperthermia at the point of DNA damage in a spheroid culture model of HT-29 colon cancer cell lines by alkaline comet assay. 43 In their study, the cells treated with a combination of hyperthermia and 5-FU or NPs as 5-FU carriers showed more DNA damage than the controls.…”

Section: Applications Of Iron Oxide Nanocrystalsmentioning

confidence: 99%

Recent insights into nanotechnology development for detection and treatment of colorectal cancer

Viswanath¹,

Kim²,

Lee³

2016

IJN

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The global incidence of colorectal cancer (CRC) is 1.3 million cases. It is the third most frequent cancer in males and females. Most CRCs are adenocarcinomas and often begin as a polyp on the inner wall of the rectum or colon. Some of these polyps become malignant, eventually. Detecting and removing these polyps in time can prevent CRC. Therefore, early diagnosis of CRC is advantageous for preventive and instant action interventions to decrease the mortality rates. Nanotechnology has been enhancing different methods for the detection and treatment of CRCs, and the research has provided hope within the scientific community for the development of new therapeutic strategies. This review presents the recent development of nanotechnology for the detection and treatment of CRC.

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“…Also, iron oxide nanoparticles are biocompatible and its 1000 times smaller than human cells so it can easily penetrate into the cells, enzymes, receptor and proteins [19]. Current approaches focus on applying iron oxide nanoparticle for magnetically driven drug delivery particularly for cancer treatment [20]. However, the low stability and aggregating nature of magnetic iron oxide nanoparticles owes to the practical difficulties to use this as a carrier.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of the Cytotoxic and Anti-Proliferative Properties of Dox-ZnO Quantum Dots Loaded Chitosan Nanoparticles against MCF-7 and SKBR-3 Human Breast Cancer Cells

Jagadeesan¹,

Roshini²,

Hwan³

et al. 2017

IJEAB

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Magnetically triggered nanovehicles for controlled drug release as a colorectal cancer therapy

Cited by 37 publications

References 46 publications

Hydrophobic Drug-Loaded PEGylated Magnetic Liposomes for Drug-Controlled Release

Hydrophobic Drug-Loaded PEGylated Magnetic Liposomes for Drug-Controlled Release

Recent insights into nanotechnology development for detection and treatment of colorectal cancer

Synthesis and Evaluation of the Cytotoxic and Anti-Proliferative Properties of Dox-ZnO Quantum Dots Loaded Chitosan Nanoparticles against MCF-7 and SKBR-3 Human Breast Cancer Cells

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