Recent insights into nanotechnology development for detection and treatment of colorectal cancer

Viswanath, Buddolla; Kim, Sang-Hyo; Lee, Ki-Young

doi:10.2147/ijn.s108715

Cited by 30 publications

(29 citation statements)

References 66 publications

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“… 47 Despite different approaches developed to detect CTCs, none of them completely meets the application requirements as loss of CTCs, low purity, and a narrow detection spectrum still need to be addressed. 29 Most of these methods include multiple operative processes, such as erythrocyte lysis, cell centrifugation and washing, which may lead to insufficient capture or cell damage and considerable time-consuming and expensive procedures. In addition, CTC detection and enumeration is still not included in routine tumor staging in clinical practice.…”

Section: Circulating Tumor Cellsmentioning

confidence: 99%

Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology

et al. 2018

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Over the last decades, the concept of precision medicine has dramatically renewed the field of medical oncology; the introduction of patient-tailored therapies has significantly improved all measurable outcomes. Liquid biopsy is a revolutionary technique that is opening previously unexpected perspectives. It consists of the detection and isolation of circulating tumor cells, circulating tumor DNA and exosomes, as a source of genomic and proteomic information in patients with cancer. Many technical hurdles have been resolved thanks to newly developed techniques and next-generation sequencing analyses, allowing a broad application of liquid biopsy in a wide range of settings. Initially correlated to prognosis, liquid biopsy data are now being studied for cancer diagnosis, hopefully including screenings, and most importantly for the prediction of response or resistance to given treatments. In particular, the identification of specific mutations in target genes can aid in therapeutic decisions, both in the appropriateness of treatment and in the advanced identification of secondary resistance, aiming to early diagnose disease progression. Still application is far from reality but ongoing research is leading the way to a new era in oncology. This review summarizes the main techniques and applications of liquid biopsy in cancer.

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Section: Circulating Tumor Cellsmentioning

confidence: 99%

Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology

et al. 2018

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“…Nanobioconjugates produced as previously described have been successfully used in the diagnosis of colorectal cancer [ 185 ]; in particular, various types of applications lead to an effective improvement of diagnostic techniques.…”

Section: Nanotechnology and Crc Diagnosismentioning

confidence: 99%

“…Magnetic nanocrystals have also been used for multimodal diagnosis employing MPI and fluorescence [ 175 ]. As far as CRC is concerned, successful applications have been made with quantum dots (QD) [ 185 ]. These NPs are constituted by nanocrystals of a semiconductor and are capable of emitting fluorescence following excitation.…”

Section: Nanotechnology and Crc Diagnosismentioning

confidence: 99%

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Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives

Pellino

Gallo

Pallante

et al. 2018

Gastroenterology Research and Practice

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Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide. It has been estimated that more than one-third of patients are diagnosed when CRC has already spread to the lymph nodes. One out of five patients is diagnosed with metastatic CRC. The stage of diagnosis influences treatment outcome and survival. Notwithstanding the recent advances in multidisciplinary management and treatment of CRC, patients are still reluctant to undergo screening tests because of the associated invasiveness and discomfort (e.g., colonoscopy with biopsies). Moreover, the serological markers currently used for diagnosis are not reliable and, even if they were useful to detect disease recurrence after treatment, they are not always detected in patients with CRC (e.g., CEA). Recently, translational research in CRC has produced a wide spectrum of potential biomarkers that could be useful for diagnosis, treatment, and follow-up of these patients. The aim of this review is to provide an overview of the newer noninvasive or minimally invasive biomarkers of CRC. Here, we discuss imaging and biomolecular diagnostics ranging from their potential usefulness to obtain early and less-invasive diagnosis to their potential implementation in the development of a bespoke treatment of CRC.

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“…Novel therapies utilizing nanomedicine can result in superior treatments as compared to the current regimens. The goal to achieve increased efficacy and reduced toxicity has been achieved by overcoming the drug delivery challenges using nanomedicine to detect and treat pancreatic ductal adenocarcinoma, 31 colorectal cancer (CRC), 32 melanoma 33 and cervical cancer. 34 …”

Section: Introductionmentioning

confidence: 99%

Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors

Zulfiqar

Mahroo

Nasir

et al. 2017

OTT

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Nanomedicine application in cancer immunotherapy is currently one of the most challenging areas in cancer therapeutic intervention. Innovative solutions have been provided by nanotechnology to deliver cytotoxic agents to the cancer cells partially affecting the healthy cells of the body during the process. Nanoparticle-based drug delivery is an emerging approach to stimulate the immune responses against cancer. The inhibition of indoleamine 2,3-dioxygenase (IDO) is a pivotal area of research in cancer immunotherapy. IDO is a heme-containing immunosuppressive enzyme, which is responsible for the degradation of tryptophan while increasing the concentration of kynurenine metabolites. Various preclinical studies showed that IDO inhibition in certain diseases may result in significant therapeutic effects. Here, we provide a review of the natural and synthetic inhibitors of IDO. These inhibitors are classified according to their source, inhibitory concentrations, the chemical structure, and the mechanism of action. Tumor-targeted chemotherapy is an advanced technique and has more advantages as compared to the conventional chemotherapy. Search for more efficient and less toxic nanoparticles in conjunction with compounds to inhibit IDO is still an area of interest for several research groups worldwide, especially revealing to be an extensive and a promising area in cancer therapeutic innovations.

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Recent insights into nanotechnology development for detection and treatment of colorectal cancer

Cited by 30 publications

References 66 publications

Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology

Liquid biopsy of cancer: a multimodal diagnostic tool in clinical oncology

Noninvasive Biomarkers of Colorectal Cancer: Role in Diagnosis and Personalised Treatment Perspectives

Nanomedicine and cancer immunotherapy: focus on indoleamine 2,3-dioxygenase inhibitors

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