Magneto‐Plasmonic Au‐Fe Alloy Nanoparticles Designed for Multimodal SERS‐MRI‐CT Imaging

Amendola, Vincenzo; Scaramuzza, Stefano; Litti, Lucio; Meneghetti, Moreno; Zuccolotto, Gaia; Rosato, Antonio; Nicolato, Elena; Marzola, Pasquina; Fracasso, Giulio; Anselmi, Cristina; Pinto, Marcella; Colombatti, Marco

doi:10.1002/smll.201303372

Cited by 172 publications

(185 citation statements)

References 76 publications

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“…These particular nanoparticles have in common that they feature magnetic properties due to their iron content. For these nanoparticles, the alloying with a noble element segregated as the shell can be used to protect the reactive iron from oxidation [61], or bimodal functionality like magneto surface-enhanced Raman scattering (SERS) [62].…”

Section: Magneticsmentioning

confidence: 99%

“…Following the first ''cocktail recipe'', dual functions can easily be obtained by either synthesis of alloy nanoparticles or by doping oxide nanoparticles. When alloy nanoparticles are used as the target material, it is possible to combine the plasmonic properties of Ag or Au with the magnetic properties of Fe [58,62,78]. This coexistence of properties can be used for imaging techniques such as multimodal SERS-MRI-CT [62].…”

Section: Dual Functionsmentioning

confidence: 99%

“…When alloy nanoparticles are used as the target material, it is possible to combine the plasmonic properties of Ag or Au with the magnetic properties of Fe [58,62,78]. This coexistence of properties can be used for imaging techniques such as multimodal SERS-MRI-CT [62]. It is also possible to combine magnetic resonance and fluorescence properties for dual-modal imaging agents [79,80].…”

Section: Dual Functionsmentioning

confidence: 99%

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Process Chain for the Fabrication of Nanoparticle Polymer Composites by Laser Ablation Synthesis

2017

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Nanoparticle polymer composites are of growing interest due to their unique properties. However, conventional composite synthesis methods usually require several process steps including steps for cleaning and improving the particlematrix dispersion. As an alternative, laser ablation synthesis can be used to prepare tunable composite materials. This method enables an easy process chain, without the need of additional steps. In this status report, the process chain of laser-based pre-series fabrication of nanocomposites is visualized, and the increase of the method's technology readiness level is demonstrated. The process steps are demonstrated from the synthesis of the colloid to applicable functional products. The advantages of using laser ablation for nanocomposite synthesis are highlighted.

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Section: Magneticsmentioning

confidence: 99%

Section: Dual Functionsmentioning

confidence: 99%

Section: Dual Functionsmentioning

confidence: 99%

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Process Chain for the Fabrication of Nanoparticle Polymer Composites by Laser Ablation Synthesis

2017

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“…Due to the higher magnetic state of Fe in Au-Fe than in pure Fe, various properties have been studied, including thickness dependent spin-glass behavior and anomalous hall conductivity in Fe/Au multilayers. [1][2][3][4][5] Due to its exceptional biocompatibility and favorable physical properties, Au-Fe nanoparticles find various applications in medical sciences, as a promising candidate for cancer cell treatment, multimodal magneto-resonance imaging agent, etc.. [6][7][8][9][10] Gold-rich Au-Fe alloys form a simple face-centeredcubic (fcc) structure. Although fcc is a high-temperature phase, Au-Fe alloys up to 53 at.%Fe are reported to be easily stabilized at room temperature.…”

mentioning

confidence: 99%

Anomalous random correlations of force constants on the lattice dynamical properties of disordered Au-Fe alloys

Kangsabanik¹,

Chouhan²,

Johnson³

et al. 2017

Phys. Rev. B

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Au-Fe alloys are of immense interest due to their biocompatibility, anomalous hall conductivity, and applications in various medical treatment. However, irrespective of the method of preparation, they often exhibit a high-level of disorder, with properties sensitive to the thermal or magnetic annealing temperatures. We calculate lattice dynamical properties of Au1−xFex alloys using density functional theory methods, where, being a multisite property, reliable interatomic force constant (IFC) calculations in disordered alloys remain a challenge. We follow a two fold approach: (1) an accurate IFC calculation in an environment with nominally zero chemical pair correlations to mimic the homogeneously disordered alloy; and (2) a configurational averaging for the desired phonon properties (e.g., dispersion, density of states, and entropy). We find an anomalous change in the IFC's and phonon dispersion (split bands) near x=0.19, which is attributed to the local stiffening of the Au-Au bonds when Au is in the vicinity of Fe. Other results based on mechanical and thermophysical properties reflect a similar anomaly: Phonon entropy, e.g., becomes negative below x=0.19, suggesting a tendency for chemical unmixing, reflecting the onset of miscibility gap in the phase diagram. Our results match fairly well with reported data, wherever available.

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“…Accompanied with the development of imaging technology, high-performance, especially those all-in-one multimodal contrast agents (MCAs) are highly demanded for accurate diagnosis and therapy. In the past several years, various of MCAs based on Au and Fe 3 O 4 nanoparticles have been developed for in vivo and pre-clinical MRI/CT imaging with the purpose of increasing the contrast of lesion, because these nanoparticles can offer facile thiol modification, enhanced chemical stability, excellent biocompatibility, superparamagnetic capability, and strong X-ray attenuation property456789101112. However, the achievement of these MCAs by using Fe 3 O 4 and Au shell always have low MRI contrast capability, because common Fe 3 O 4 can only provide T 2 weight MRI with dark imaging and Au shell coated on the surface of Fe 3 O 4 also prevent the connection with water molecules in tissue resulting in the reduction of the MRI contrast signal.…”

mentioning

confidence: 99%

Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1–T2Dual MRI and CT Imaging of Tumor

Wang

Gao

Zhang

et al. 2016

Sci Rep

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Diagnostic approaches based on multimodal imaging of clinical noninvasive imaging (eg. MRI/CT scanner) are highly developed in recent years for accurate selection of the therapeutic regimens in critical diseases. Therefore, it is highly demanded in the development of appropriate all-in-one multimodal contrast agents (MCAs) for the MRI/CT multimodal imaging. Here a novel ideal MCAs (F-AuNC@Fe3O4) were engineered by assemble Au nanocages (Au NC) and ultra-small iron oxide nanoparticles (Fe3O4) for simultaneous T1–T2dual MRI and CT contrast imaging. In this system, the Au nanocages offer facile thiol modification and strong X-ray attenuation property for CT imaging. The ultra-small Fe3O4 nanoparticles, as excellent contrast agent, is able to provide great enhanced signal of T1- and T2-weighted MRI (r1 = 6.263 mM−1 s−1, r2 = 28.117 mM−1 s−1) due to their ultra-refined size. After functionalization, the present MCAs nanoparticles exhibited small average size, low aggregation and excellent biocompatible. In vitro and In vivo studies revealed that the MCAs show long-term circulation time, renal clearance properties and outstanding capability of selective accumulation in tumor tissues for simultaneous CT imaging and T1- and T2-weighted MRI. Taken together, these results show that as-prepared MCAs are excellent candidates as MRI/CT multimodal imaging contrast agents.

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Magneto‐Plasmonic Au‐Fe Alloy Nanoparticles Designed for Multimodal SERS‐MRI‐CT Imaging

Cited by 172 publications

References 76 publications

Process Chain for the Fabrication of Nanoparticle Polymer Composites by Laser Ablation Synthesis

Process Chain for the Fabrication of Nanoparticle Polymer Composites by Laser Ablation Synthesis

Anomalous random correlations of force constants on the lattice dynamical properties of disordered Au-Fe alloys

Au Nanocage Functionalized with Ultra-small Fe3O4 Nanoparticles for Targeting T1–T2Dual MRI and CT Imaging of Tumor

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