Magnetocubosomes for the delivery and controlled release of therapeutics

Montis, Costanza; Castroflorio, Benedetta; Mendozza, Marco; Salvatore, Annalisa; Berti, Debora; Baglioni, Piero

doi:10.1016/j.jcis.2014.11.056

Cited by 58 publications

(50 citation statements)

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“…In a study by Montis et al [21], the fabrication and characterization of a drug delivery system (DDS) with hydrophobic Fe 3 O 4 NPs embedded in the bilayer of bicontinuous cubic lipid NPs of glyceryl monooleate (GMO) was reported. The "magnetocubosomes" synthesized are investigated and characterized by their ability to incorporate and release both hydrophobic and hydrophilic drugs.…”

Section: Magnetic Np (Mnp) Synthesis and Magnetoliposome (Mp) Formationmentioning

confidence: 99%

“…The "magnetocubosomes" synthesized are investigated and characterized by their ability to incorporate and release both hydrophobic and hydrophilic drugs. Magnetocubosomes were reported for the first time as a novel multifunctional, biocompatible, and responsive DDS [21]. This novel hybrid composite can represent an extremely flexible and interesting device for the targeted delivery of diagnostic agents and multiple therapeutic.…”

Section: Magnetic Np (Mnp) Synthesis and Magnetoliposome (Mp) Formationmentioning

confidence: 99%

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Recent advances in magnetoliposome for heart drug delivery

Namdari

Cheraghi

Negahdari

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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Magnetic nanoparticles (NPs) also have been subject of interest to the therapeutic and imaging field because of their unique magnetic properties. Magnetoliposomes (MLs) are made up of a combination of liposomes and magnetic NPs, and they have been proven to be a potential biomaterial to fields like magnetic-targeted drug delivery, MRI, etc. The efficiency of a drug delivery system to the heart determines the treatment strategy for most of the heart diseases. In this review article, we summarize the recent development and updates in the application of MLs as a drug delivery system for heart/cardiac diseases.

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Section: Magnetic Np (Mnp) Synthesis and Magnetoliposome (Mp) Formationmentioning

confidence: 99%

Section: Magnetic Np (Mnp) Synthesis and Magnetoliposome (Mp) Formationmentioning

confidence: 99%

Recent advances in magnetoliposome for heart drug delivery

Namdari

Cheraghi

Negahdari

et al. 2017

Artificial Cells, Nanomedicine, and Biotechnology

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“…showed that the monoolein cubic phase with MNPs subjected to AMF for 10 minutes indicate Pn3m to HII phase transition. [40] Other works [28,30,32,41,42] rely on the so-called magnetothermal effect observed in an alternating magnetic field. This effect reveals itself as temperature rises, transferring heat to the immediate vicinity when the magnetic nanoparticles are exposed to the alternating magnetic field of sufficiently high frequency (typically from several kHz to hundreds of kHz) due to the Néel and Brownian relaxation [43].…”

Section: Low-frequency Alternatingmentioning

confidence: 99%

“…[24] Magnetic nanoparticles and ions are currently of great interest in research related to medical applications [25] and are used as contrast agents for theranostics in medical imaging applications [26]. Few reported studies examined the effect of the addition of nanoparticles to liquid crystalline hexagonal phase [27], liposomes [28,29] and cubosomes [30][31][32] creating a magnetic responsive system.…”

Section: Introductionmentioning

confidence: 99%

Hybrid delivery systems for methotrexate-lipidic liquid crystalline cubic phases and cubosomes with magnetic nanoparticles

M¹,

Krysiński²,

Bilewicz³

2019

Preprint

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The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although deviating from the model when the temperature was increased. Magnetocubosomes - cubic phase nanoparticles containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid materials are very promising, allowing to control the release of the drug at the appropriate sites, but do require further investigations into their in vitro cytotoxicity and in vivo biodistribution.

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“…24,25 Exposure to a stimulus can result in the specic alteration of the global physicochemical properties of the matrix such as viscosity. 26 Most importantly, for application in active drug delivery, dynamic release of encapsulated drug from these nanostructured matrices has been demonstrated using temperature, 27 pH, 28 light activation of photothermal nanoparticles 29,30 and a magnetic eld, 31,32 whereby the application of the external stimulus has induced a phase transition and consequent alteration of the release rate that reects the change in nanostructure. 33 Lipidic mesophases are thermodynamically stable and consequently can be dispersed into sub-micron particles with preserved internal nanostructure and colloidal stability commonly imparted by block copolymers, proteins and particles.…”

Section: Introductionmentioning

confidence: 99%