Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural‐like cells

Esmaeili, Elaheh; Soleimani, Masoud; Ghiass, Mohammad Adel; Hatamie, Shadie; Vakilian, Saeed; Zomorrod, Mahsa Soufi; Sadeghzadeh, Negar; Vossoughi, Manouchehr; Hosseinzadeh, Simzar

doi:10.1002/jcp.28040

Cited by 44 publications

(30 citation statements)

References 70 publications

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“…However, the effect of electromagnetic activities on neurogenesis remains controversial. The effect of PVDF on neural stem cells isolated in the later time of embryonic development was shown previously [63]. However, isolation of cells at an earlier stage of embryonic development gives the ability to direct their differentiation is more addressed, but biocompatibility of materials should be studied additionally.…”

Section: Biological Testsmentioning

confidence: 89%

Boosting Magnetoelectric Effect in Polymer-Based Nanocomposites

et al. 2021

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Polymer-based magnetoelectric composite materials have attracted a lot of attention due to their high potential in various types of applications as magnetic field sensors, energy harvesting, and biomedical devices. Current researches are focused on the increase in the efficiency of magnetoelectric transformation. In this work, a new strategy of arrangement of clusters of magnetic nanoparticles by an external magnetic field in PVDF and PFVD-TrFE matrixes is proposed to increase the voltage coefficient (αME) of the magnetoelectric effect. Another strategy is the use of 3-component composites through the inclusion of piezoelectric BaTiO3 particles. Developed strategies allow us to increase the αME value from ~5 mV/cm·Oe for the composite of randomly distributed CoFe2O4 nanoparticles in PVDF matrix to ~18.5 mV/cm·Oe for a composite of magnetic particles in PVDF-TrFE matrix with 5%wt of piezoelectric particles. The applicability of such materials as bioactive surface is demonstrated on neural crest stem cell cultures.

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Section: Biological Testsmentioning

confidence: 89%

Boosting Magnetoelectric Effect in Polymer-Based Nanocomposites

et al. 2021

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“…Another emerging and effective method for repairing and replacing damaged central nervous system tissues is based on the induction of exogenous stem cell neurogenesis [154]. In this context, a high-performance magneto-electric (ME) scaffold was proposed to induce neural cell differentiation without the use of chemical differentiation factors [155]. For the preparation of the scaffold, polyvinylidene difluoride (PVDF) in the crystalline β phase was obtained in order to exploit its piezoelectric features.…”

Section: Soft Tissue Cellular Response Modulation By Magnetic Scaffoldsmentioning

confidence: 99%

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

et al. 2020

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The burst of research papers focused on the tissue engineering and regeneration recorded in the last years is justified by the increased skills in the synthesis of nanostructures able to confer peculiar biological and mechanical features to the matrix where they are dispersed. Inorganic, organic and hybrid nanostructures are proposed in the literature depending on the characteristic that has to be tuned and on the effect that has to be induced. In the field of the inorganic nanoparticles used for decorating the bio-scaffolds, the most recent contributions about the paramagnetic and superparamagnetic nanoparticles use was evaluated in the present contribution. The intrinsic properties of the paramagnetic nanoparticles, the possibility to be triggered by the simple application of an external magnetic field, their biocompatibility and the easiness of the synthetic procedures for obtaining them proposed these nanostructures as ideal candidates for positively enhancing the tissue regeneration. Herein, we divided the discussion into two macro-topics: the use of magnetic nanoparticles in scaffolds used for hard tissue engineering for soft tissue regeneration.

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“…The magnetic properties of the core-shell nanostructures are reported to improve due to the diverse coupling interactions between the core and shell nano particles via interfacial defect acts as anisotropy in ferro-ferri and ferro-anti ferro magnetic structures [33][34][35], which make them great candidates to use in magnetic imaging [36][37][38]. In this study, we used the seed-growth technique to prepare spherical cobalt ferrite (s-CoFe 2 O 4 ) as a magnetic core template to cover with the cubic iron oxide as shell (c-Fe 3 O 4 ) to form (s-CoFe 2 O 4 @c-Fe 3 O 4 ) core-shell NPs [39][40][41][42]. The WS 2 nanosheets were synthesized by a series of chemical methods followed by a non-oxygen annealing process.…”

Section: Introductionmentioning

confidence: 99%

Synergic Effect of Novel WS2 Carriers Holding Spherical Cobalt Ferrite @cubic Fe3O4 (WS2/s-CoFe2O4@c-Fe3O4) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration

et al. 2020

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The design of novel materials to use simultaneously in an ocular system for driven therapeutics and wound healing is still challenging. Here, we produced nanocomposites of tungsten disulfide carriers with spherical cobalt ferrite nanoparticles (NPs) as core inside a cubic iron oxide NPs shell (WS2/s-CoFe2O4@c-Fe3O4). Transmission electron microscopy (TEM) confirmed that 10 nm s-CoFe2O4@c-Fe3O4 NPs were attached on the WS2 sheet surfaces. The cytotoxicity of the WS2 sheets and nanocomposites were evaluated on bovine cornea endothelial cells (BCECs) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay for a duration of three days. The MTT assay results showed low toxicity of the WS2 sheets on BCECs by 67% cell viability at 100 μg/mL in 24 h, while the nanocomposites show 50% cell viability in the same conditions. The magnetic resonance imaging (MRI) of nanocomposites revealed the excellent T2-weighted imaging with an r2 contrast of 108 mM−1 S−1. The in vitro photothermal therapy based on WS2 sheets and WS2/s-CoFe2O4 @c-Fe3O4 nanocomposites using 808 nm laser showed that the maximum thermal energy dispatched in medium at different applied power densities (1200 mw, 1800, 2200, 2600 mW) was for 0.1 mg/mL of the sample solution. The migration assay of BCECs showed that the wound healing was approximately 20% slower for the cell exposed by nanocomposites compared with the control (no exposed BCECs). We believe that WS2/s-CoFe2O4@c-Fe3O4 nanocomposites have a synergic effect as photothermal therapy agents for eye diseases and could be a target in an ocular system using MRI.

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Magnetoelectric nanocomposite scaffold for high yield differentiation of mesenchymal stem cells to neural‐like cells

Cited by 44 publications

References 70 publications

Boosting Magnetoelectric Effect in Polymer-Based Nanocomposites

Boosting Magnetoelectric Effect in Polymer-Based Nanocomposites

Paramagnetic Functionalization of Biocompatible Scaffolds for Biomedical Applications: A Perspective

Synergic Effect of Novel WS2 Carriers Holding Spherical Cobalt Ferrite @cubic Fe3O4 (WS2/s-CoFe2O4@c-Fe3O4) Nanocomposites in Magnetic Resonance Imaging and Photothermal Therapy for Ocular Treatments and Investigation of Corneal Endothelial Cell Migration

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