Magnetoferritin: Process, Prospects, and Their Biomedical Applications

Xue, Le; Deng, Dawei; Sun, Jianfei

doi:10.3390/ijms20102426

Cited by 28 publications

(15 citation statements)

References 103 publications

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“…External stimuli-responsive DDS includes release of payload by physical triggers, such as temperature [ 262 , 263 ], electromagnetic stimuli such as photodynamic therapy [ 264 ], ultrasound [ 265 ], electric field [ 266 ], and applied mechanical force [ 267 ]. Jose et al developed temperature-sensitive liposomes encapsulating tamoxifen and imatinib drugs for breast cancer treatment.…”

Section: Nanomedicine To Overcome Drug Resistance In Breast Cancermentioning

confidence: 99%

Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

Gote

Nookala

Bolla

et al. 2021

IJMS

101

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Breast cancer, specifically metastatic breast, is a leading cause of morbidity and mortality in women. This is mainly due to relapse and reoccurrence of tumor. The primary reason for cancer relapse is the development of multidrug resistance (MDR) hampering the treatment and prognosis. MDR can occur due to a multitude of molecular events, including increased expression of efflux transporters such as P-gp, BCRP, or MRP1; epithelial to mesenchymal transition; and resistance development in breast cancer stem cells. Excessive dose dumping in chemotherapy can cause intrinsic anti-cancer MDR to appear prior to chemotherapy and after the treatment. Hence, novel targeted nanomedicines encapsulating chemotherapeutics and gene therapy products may assist to overcome cancer drug resistance. Targeted nanomedicines offer innovative strategies to overcome the limitations of conventional chemotherapy while permitting enhanced selectivity to cancer cells. Targeted nanotheranostics permit targeted drug release, precise breast cancer diagnosis, and importantly, the ability to overcome MDR. The article discusses various nanomedicines designed to selectively target breast cancer, triple negative breast cancer, and breast cancer stem cells. In addition, the review discusses recent approaches, including combination nanoparticles (NPs), theranostic NPs, and stimuli sensitive or “smart” NPs. Recent innovations in microRNA NPs and personalized medicine NPs are also discussed. Future perspective research for complex targeted and multi-stage responsive nanomedicines for metastatic breast cancer is discussed.

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Section: Nanomedicine To Overcome Drug Resistance In Breast Cancermentioning

confidence: 99%

Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

Gote

Nookala

Bolla

et al. 2021

IJMS

101

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“…NPs present good penetrability, even crossing the blood-brain barrier [97], and target tumor cells, which express high numbers of transferrin receptors [98]. Transferrin-bound nanoparticles are adopted in theragnostics [99] to achieve improved results.…”

Section: Theranosticsmentioning

confidence: 99%

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

2021

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Understanding of how the human organism functions has preoccupied researchers in medicine for a very long time. While most of the mechanisms are well understood and detailed thoroughly, medicine has yet much to discover. Iron (Fe), Copper (Cu), and Zinc (Zn) are elements on which organisms, ranging from simple bacteria all the way to complex ones such as mammals, rely on these divalent ions. Compounded by the continuously evolving biotechnologies, these ions are still relevant today. This review article aims at recapping the mechanisms involved in Fe, Cu, and Zn homeostasis. By applying the knowledge and expanding on future research areas, this article aims to shine new light of existing illness. Thanks to the expanding field of nanotechnology, genetic disorders such as hemochromatosis and thalassemia can be managed today. Nanoparticles (NPs) improve delivery of ions and confer targeting capabilities, with the potential for use in treatment and diagnosis. Iron deficiency, cancer, and sepsis are persisting major issues. While targeted delivery using Fe NPs can be used as food fortifiers, chemotherapeutic agents against cancer cells and microbes have been developed using both Fe and Cu NPs. A fast and accurate means of diagnosis is a major impacting factor on outcome of patients, especially when critically ill. Good quality imaging and bed side diagnostic tools are possible using NPs, which may positively impact outcome.

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“…Magnetoferritin can be used as standard in diagnosis of various diseases, contrast agent in MRI, drug delivery system for targeted anti-cancer therapy, catalytic agent (peroxidaselike activity: protective agent against oxidative stress, destruction activity on fibrils responsible for amyloid disorders), etc. (Koralewski et al, 2012;Melnikova et al, 2014;Kopcansky et al, 2015;Strbak et al, 2017;Xue et al, 2019). According to the fact that magnetoferritin is expensive material related to the apoferritin origin, which is isolated from the biological organism (horse spleen), its use is limited to a large extent against surface water, groundwater and wastewater treatment.…”

Section: Possibilities and New Approaches Of Nitrates Decontaminationmentioning

confidence: 99%

Relationship of nitrates and nitrites in the water environment with humans and their activity

Balejčíková¹,

Tall²,

Kandra³

et al. 2020

ahs

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Nitrates and nitrites in water pose a health and environmental hazards, in particular when exceeding limits defined in the European Union, i.e. max. 50 mg l-1 of nitrates. It is not recommended to exceed the limit of 10 mg l-1 of nitrates for infants and children. The maximum concentration of nitrites is 0.5 mg l-1 for adults and infants less than 0.1 mg l-1. Our work offers a review of the water quality concerning the relationship between nitrates/nitrites and humans. Basic properties and forms of nitrates, their use for human activities, importance and risks to human health and possibilities of their physicochemical determination are summarized. Our study demonstrates also the novel approaches to the nitrates decontamination in a water environment using various nanomaterials. We aimed at a collection of records from the monitoring of nitrates in selected areas in Slovakia to show good quality of water in various water sources, which over time improves due to the increasingly low fertilization intensity and thus of agriculture production, which is gradually being replaced by imports.

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Magnetoferritin: Process, Prospects, and Their Biomedical Applications

Cited by 28 publications

References 103 publications

Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

Drug Resistance in Metastatic Breast Cancer: Tumor Targeted Nanomedicine to the Rescue

Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications

Relationship of nitrates and nitrites in the water environment with humans and their activity

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