Magnetofluorescent Carbon Quantum Dot Decorated Multiwalled Carbon Nanotubes for Dual-Modal Targeted Imaging in Chemo-Photothermal Synergistic Therapy

Abstract

Magnetofluorescent nanoparticles with diagnostic and therapeutic functions show great promise in nanomedicine.Here, we report the magnetofluorescent carbon nanotubes (CNTs)/doxorubicin (DOX) nanocomposites and their functions act in synergetic chemo-photothermal synergistic therapy (Chemo/PTT) in cancer excision. Magnetofluorescent CNTs conjugated with a folic acid

Near-infrared light-mediated photodynamic/photothermal therapy nanoplatform by the assembly of Fe₃O₄ carbon dots with graphitic black phosphorus quantum dots

“…Then, genipin (GP)-PGA-Fe 3 O 4 -CDs@BPQDs were readily synthesized via the self-polymerization of genipin according to our previous methods. 20 We determined from typical TEM images that the resultant GP-PGA-Fe 3 O 4 -CDs@ BPQDs were spherical with an average diameter of 102±8 nm ( Figure 1F and G) and the size of GP-PGA-Fe 3 O 4 -CDs@ BPQDs within the accepted range, which enabled efficient uptake by tumors based on the enhanced permeability and retention (EPR) effect. Furthermore, the as-prepared GP-PGA-Fe 3 O 4 -CDs@BPQDs dispersed well in NaCl, PBS, FBS, and DMEM solutions and remained stable for 1 week without any detectable agglomeration ( Figure S4B).…”

“…19 In addition, BPQDs show broad absorption across the entire visible-light region, resulting in near-infrared (NIR) PT properties suitable for PTT. 20 Considering the unique electronic structure of BPQDs, we expect that it may be a new metal-free semiconductor to generate singlet oxygen, which can be further applied in catalysis and PDT applications. All the unique properties of BPQDs make them a promising new nanostructured system in terms of multimodal therapy for cancer.…”

“…Significant efforts to assist physicians in diagnosing and monitoring the response to therapy have been made using advances toward personalized therapeutic approaches and by increasing the precision of surgical techniques using multimodal imaging. 20 Researchers have already explored many methods for enhancing the accuracy and efficiency of selective localization during treatment, such as magnetic targeting, molecular targeting, and imaging guidance. In particular, magnetic targeting, which can be achieved using iron oxide nanoparticles in the treatment platform, not only locates the physical position of drugs but also simultaneously realizes the magnetic resonance imaging (MRI)-guided therapy effect.…”

One‐Pot Synthesis of Magnetic Nanoparticles Encapsulated by Carbon Nanotube for Selective Aromatic Compound Adsorption

“…For example, the combination of CNTs with polyhydroxy metal oxides gives the CNTs better application features such as water dispersibility and ease of separation . In the field, many efforts of scientists were devoted to fabricating magnetic CNTs for potential applications in magnetic resonance imaging, separation of pollutants and magnetically guided drug delivery systems, etc . Moreover, the combination of CNTs with magnetic materials can solve the disadvantages of recycling of CNTs in some practical applications.…”

Multifunctional Nanocomposites for Targeted, Photothermal, and Chemotherapy

“…[23][24][25] Therefore, in the process of later clinical treatment, improving the drug targeting, enhancing the drug curative effect while minimizing adverse drug side effects are needed. 26,27 ZnO NPs have been widely used in biocidal applications, sensor designing, catalysis and gas sensing; however, these nanostructures in drug delivery system are still in a nascent stage. [28][29][30] Most recently, ZnO NPs have been explored as nano-vectors for targeted drug delivery systems, behaving as (1) biological modification, 31 or (2) ZnO NPs based drug delivery system.…”