Magnetoliposomes: Versatile Innovative Nanocolloids for Use in Biotechnology and Biomedicine

Soenen, Stefaan J.; Hodenius, Michael; Cuyper, Marcel De

doi:10.2217/17435889.4.2.177

Cited by 105 publications

(83 citation statements)

References 88 publications

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“…93 If the superparamagnetic particles are SPIONs, the MLPs can be used as T 2 contrast agents, whereas if USPIONs are used, the MLPs produce a T 1 contrast. 75,77,94 The term MLP denotes several types of phospholipid-iron oxide constructs with totally different properties. The original MLPs consisted of iron oxide cores, upon which a single phospholipid bilayer was adsorbed.…”

Section: Paramagnetic/superparamagnetic Liposomes: Versatile Mri Probesmentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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Section: Paramagnetic/superparamagnetic Liposomes: Versatile Mri Probesmentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

281

106

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“…47 Examples include magnetic targeting of drugs encapsulated in magnetic responsive carriers to tissues, magnetic heating of (e.g. cancerous) tissues (magnetic hyperthermia) 48,49 and time controlled release of drugs from magnetic responsive polymer hydrogels. 50 Bulk ferromagnetic materials, such as magnetite, consist of multiple magnetic domains (Weiss domains) which are all randomly oriented, leading to zero net magnetization.…”

Section: Magnetic Field-responsive Electrospun Fibersmentioning

confidence: 99%

Stimuli-responsive electrospun fibers and their applications

et al. 2011

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In this critical review, an overview is given on recent advances in the development and application of stimuliresponsive electrospun nanofibers.Please check this proof carefully. Our staff will not read it in detail after you have returned it. Translation errors between word-processor files and typesetting systems can occur so the whole proof needs to be read. Please pay particular attention to: tabulated material; equations; numerical data; figures and graphics; and references. If you have not already indicated the corresponding author(s) please mark their name(s) with an asterisk. Please e-mail a list of corrections or the PDF with electronic notes attached --do not change the text within the PDF file or send a revised manuscript.Please bear in mind that minor layout improvements, e.g. in line breaking, table widths and graphic placement, are routinely applied to the final version.Please note that, in the typefaces we use, an italic vee looks like this: n, and a Greek nu looks like this: n.We will publish articles on the web as soon as possible after receiving your corrections; no late corrections will be made.Please return your final corrections, where possible within 48 hours of receipt, by e-mail to: chemsocrev@rsc.org Reprints-Electronic (PDF) reprints will be provided free of charge to the corresponding author. Enquiries about purchasing paper reprints should be addressed via: http://www.rsc.org/publishing/journals/guidelines/paperreprints/. Costs for reprints are below: Stimuli-responsive electrospun nanofibers are gaining considerable attention as highly versatile tools which offer great potential in the biomedical field. In this critical review, an overview is given on recent advances made in the development and application of stimuli-responsive fibers. The specific features of these electrospun fibers are highlighted and discussed in view of the properties required for the diverse applications. Furthermore, several novel biomedical applications are discussed and the respective advantages and shortcomings inherent to stimuli-responsive electrospun fibers are addressed (136 references).

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“…It has been accepted that for these slowly or non degrading particles, cell division usually results in an exponential decrease in the intracellular concentration of the particles, as in general both daughter cells receive approximately 50% of the particles. Recently, several studies questioned the general applicability of this finding [85,86].…”

Section: Mitotic Partitioning Of Inorganic Quantum Dots Gold and Iromentioning

confidence: 99%

Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis

Symens

Soenen

Rejman

et al. 2012

Advanced Drug Delivery Reviews

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Magnetoliposomes: Versatile Innovative Nanocolloids for Use in Biotechnology and Biomedicine

Cited by 105 publications

References 88 publications

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Stimuli-responsive electrospun fibers and their applications

Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis

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