Magnetostrictive-Piezoelectric-Triggered Nanocatalytic Tumor Therapy

Abstract

Magnetic-based theranostics feature a high efficiency, excellent tissue penetration, and minimal damage to normal tissues, are noninvasive, and are widely used in the diagnosis and therapy of clinical diseases. Herein, a conceptually novel magnetostrictive-piezoelectric nanocatalytic medicine (MPE-NCM) for tumor therapy is proposed by initiating an intratumoral magneto-driven and piezoelectric-catalyzed reaction using core–shell structured CoFe2O4–BiFeO3 magnetostrictive-piezoelectric nanoparticles (CFO-BFO NPs) under an alternating magnetic field. The CFO-BFO NPs catalyze the generation of cytotoxic reactive oxygen species (ROS): superoxide radicals (•O2 –) and hydroxyl radicals (•OH). The simulation calculation demonstrates the highly controllable electric polarization, facilitating the above catalytic reactions under the magnetic stimulation. Both a detailed cell-level assessment and the tumor xenograft evaluation evidence the significant tumor eradication efficacy of MPE-NCM. This study proposes an original and novel magneto-responsive nanocatalytic modality for cancer therapy, which displays promising prospects for the future clinic translation owing to its excellent catalytic dynamic responsiveness, high therapeutic efficacy, and biosafety in vivo.

Bioinspired Electron Polarization of Nanozymes with a Human Self‐Generated Electric Field for Cancer Catalytic Therapy

“…Once ROS generation is inadequate, due to the upregulated antioxidant defense system of tumor cells, the cells may escape or recover from oxidative damage, which may lead to tumor proliferation, recurrence, and metastasis. [3] Recently, to activate the current nanozymes and improve their catalytic activities and therapeutic outcomes, different external stimulators have been locally used to improve the catalytic efficiency, including near-infrared light, [4] ultrasound, [5] magnetic field, [6] microwave, [7] and electricity. [8] With regard to using electricity as a stimulator, natural protein enzymes are considered to have strong and permanent electrostatic fields in their active sites, which are believed to be the major factor responsible for the binding of these enzymes with substrates and subsequent catalytic reactions, namely the electrostatic preorganization effect.…”

“…Once ROS generation is inadequate, due to the upregulated antioxidant defense system of tumor cells, the cells may escape or recover from oxidative damage, which may lead to tumor proliferation, recurrence, and metastasis. [ 3 ] Recently, to activate the current nanozymes and improve their catalytic activities and therapeutic outcomes, different external stimulators have been locally used to improve the catalytic efficiency, including near‐infrared light, [ 4 ] ultrasound, [ 5 ] magnetic field, [ 6 ] microwave, [ 7 ] and electricity. [ 8 ]…”

Tumor microenvironment-activated single-atom platinum nanozyme with H2O2 self-supplement and O2-evolving for tumor-specific cascade catalysis chemodynamic and chemoradiotherapy

“…Chemodynamic therapy (CDT), which takes advantage of iron-mediated Fenton reaction or Cu 2+ -/Mn 2+ -mediated Fenton-like reaction to convert less reactive H 2 O 2 into highly toxic ·OH for inducing cell apoptosis and necrosis 1 - 4 , has attracted widespread attention in recent years due to its high selectivity and logicality as well as activation of endogenous stimuli 5 - 9 . To date, despite tremendous efforts have been achieved in triggering tumor cells apoptosis by the endogenous H 2 O 2 -dependent Fenton reaction in CDT 10 - 14 , their therapeutic effectiveness remains a great challenge due to the tumor microenvironment (TME) characterized by insufficient endogenous hydrogen peroxide (H 2 O 2 , 50-100×10 -6 M) 6 , 15 - 17 , overexpressed glutathione (GSH) 18 - 24 as well as hypoxia microenvironment 25 - 32 . Therefore, to potentially enhance their antitumor efficiency, several H 2 O 2 -supplementing strategies have been applied to convey exogenous H 2 O 2 or trigger endogenous H 2 O 2 generation in the tumor site 16 , 33 - 37 .…”

Magnetoelectric dissociation of Alzheimer’s β-amyloid aggregates

“…Recently, Mushtaq et al (11)(12)(13) reported that BFOcoated CFO (BCFO) can efficiently generate excited charge carriers in response to low-frequency magnetic field (e.g., below 1.1 kHz). Furthermore, the magnetic field-responsive BCFO is biocompatible with human cells [e.g., osteoblasts (12) and neuronal cells (14)] and mouse models (15), hinting at its potential for medical applications.…”