Main Predictors of Coronavirus Disease Severity Prognosis

Abstract

Coronavirus disease can have a variety of clinical symptoms, ranged from asymptomatic to severe and even critical ones. To date, an information on the epidemiology, clinical features, prevention and treatment of this disease is insufficient, which requires a further study of the problem. To personalize the treatment, it is important to determine the leading clinical and laboratory predictors to forecast the severity of COVID−19. The algorithm of examination of a patient includes the assessment of all complaints, data of the anamnesis of the disease, epidemiological anamnesis. The combination of clinical examination to determine the severity of the patient's condition includes physical examination, the one of diagnostic material using methods of nucleic acid amplification and / or enzyme−linked immunosorbent assay, pulse oximetry. Laboratory, etiological diagnostics, tests and antibodies play an important role. In case of hospitalization of the patients with moderate, severe and extremely severe infection, clinical studies are required such as: general (clinical) and biochemical blood test, coagulogram, diagnosis of disseminated intravascular coagulation syndrome, as well as identification of risk factors. Instrumental and radiological diagnostics include: pulse oximetry with measurement of SpO2 level, computed tomography and ultrasound examination of lungs and pleural cavities, electrocardiography. Comprehensive evaluation of clinical and laboratory data of patients allows to determine a clinically confirmed COVID−19, to route the patient and to start complex therapy in time. A promising direction is the introduction of the method of quantitative diagnostics by polymerase chain reaction on SARS−CoV−2 RNA in the activity of laboratories of Ukraine, which will help to individualize the degree of viral load in patients, improve treatment control. Key words: COVID−19, predictors of course severity, methods of laboratory diagnostics, quantitative polymerase chain reaction.