Maintenance of growth transformation with Epstein-Barr virus is mediated by secretion of autocrine growth factors in two serum-free B-cell lines

Shaw, James E.; Baglia, Laurel A.; Leung, Kiu

doi:10.1128/jvi.62.9.3415-3421.1988

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1991

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Cited by 8 publications

References 62 publications

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Activity of soluble factors produced by Epstein-Barr virus-transformed human B lymphocytes on different cell lines

Garzelli

Bazzichi

1991

Experientia

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Self-stimulatory growth factors, produced by a human Epstein-Barr virus (EBV)-positive lymphoblastoid B cell line, named BA-D10-4, have been tested for the capacity to induce DNA synthesis in various human and animal cell lines, including lymphoid, either EBV-positive or EBV-negative, and non-lymphoid cell lines. It has been found that BA-D10-4 cells produce growth factors which seem to be essential for their sustained proliferation in vitro, and which increase DNA synthesis in different primate lymphoid cells, independently of the presence of the EBV genome and of the lymphocyte lineage.

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