Maintenance of NF-κB Activation in T-Lymphocytes and a Naive T-Cell Population in Autoimmune-Prone (NZB/NZW)F1 Mice by Feeding a Food-Restricted Diet Enriched with n-3 Fatty Acids

Jolly, Christopher A.; Muthukumar, Alagarraju; Avula, C. P. Reddy; Fernandes, Gabriel

doi:10.1006/cimm.2001.1866

Cited by 40 publications

(20 citation statements)

References 52 publications

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“…In murine models of SLE, modulation of fatty acid metabolism by increasing n-3 PUFAs intake can result in a therapeutic effect 18 – 21. High-dose (20 g daily) n-3 PUFAs has been shown to improve clinical features of SLE and our group has also previously shown a reduction in SLE disease activity with low-dose n-3 PUFAs 22…”

mentioning

confidence: 87%

A randomised interventional trial of Ï‰-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus

Wright

O'Prey

McHenry

et al. 2008

Annals of the Rheumatic Diseases

136

100

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mentioning

confidence: 87%

A randomised interventional trial of Ï‰-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus

Wright

O'Prey

McHenry

et al. 2008

Annals of the Rheumatic Diseases

136

100

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“…Mice unable to activate the p50:p65 signaling pathway can only mount Th2 immune responses to infections (11). By manipulating the dietary intake of lupus-prone mice, Jolly et al (31) were able to demonstrate that disease-associated losses in Th1 cytokine production were due to diminished NF-B activation. In addition, the changes in T cell-mediated immunity after severe injury that result in suppressed Th1 responses and increased or persistent Th2 cytokine production are due to diminished NF-B activity (32).…”

Section: Il-10 In Cd3mentioning

confidence: 99%

Pregnancy-Specific Down-Regulation of NF-κB Expression in T Cells in Humans Is Essential for the Maintenance of the Cytokine Profile Required for Pregnancy Success

McCracken

Gallery

Morris

2004

The Journal of Immunology

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It is accepted that human pregnancy is associated with a shift away from Th1 type and a bias toward Th2-type immune responses. The molecular mechanisms that regulate this shift are as yet unknown. We assessed the expression and activity of NF-κB, a transcription factor that plays a central role in regulating immune responses. We isolated T cells from PBMCs from nonpregnant and pregnant females and demonstrated that the NF-κB/IκB signaling pathway is down-regulated in T cells in pregnancy. Using Western blotting, high levels of NF-κB (p65) were detected in all nuclear fractions of T cells from nonpregnant females. In contrast, low levels of p65 were detected in nuclear fractions from T cells from pregnant females. Levels of IκBα and -β were also higher in cytoplasmic fractions from T cells from nonpregnant than from pregnant females. The reduction in p65 levels in pregnancy was reflected in the activity of NF-κB in EMSA; T cells from pregnant females contain less active NF-κB than from nonpregnant females. Stimulation of T cells from nonpregnant females with PMA/ionomycin resulted in IκBα degradation, p65 translocation, and subsequent production of the Th1 cytokines IFN-γ and IL-2. In contrast, PMA stimulation had no effect on NF-κB activity in T cells from pregnant females, and this was reflected in reduced Th1 cytokine production. Using the inhibitor of NF-κB activity, SN50, we were able to show that NF-κB activity was essential for the production of Th1 cytokines, suggesting that specific down-regulation of NF-κB in T cells throughout gestation is paramount to pregnancy success through specific regulation of cytokine production.

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“…In preliminary studies with LLC-PK 1 cells such effect was observed primarily on c-jun N-terminal kinase (Johnson et al, 2003). Since PKC and MAPK induce various cytokines by involving the activation of nuclear factor B (NFB) and lupus-prone mice have reduced activation of NFB (Jolly et al, 2001), it may be speculated that the reduced induction of cytokines in the NZBW strain is related to their decreased NFB activity.…”

Section: Discussionmentioning

confidence: 99%

Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine

Sharma

Riley

2005

Toxicology

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Maintenance of NF-κB Activation in T-Lymphocytes and a Naive T-Cell Population in Autoimmune-Prone (NZB/NZW)F1 Mice by Feeding a Food-Restricted Diet Enriched with n-3 Fatty Acids

Cited by 40 publications

References 52 publications

A randomised interventional trial of Ï‰-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus

A randomised interventional trial of Ï‰-3-polyunsaturated fatty acids on endothelial function and disease activity in systemic lupus erythematosus

Pregnancy-Specific Down-Regulation of NF-κB Expression in T Cells in Humans Is Essential for the Maintenance of the Cytokine Profile Required for Pregnancy Success

Lupus-prone NZBWF1/J mice, defective in cytokine signaling, are resistant to fumonisin hepatotoxicity despite accumulation of liver sphinganine

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