Major Adverse Events in Patients with Peripheral Artery Disease after Endovascular Revascularization: A Retrospective Study

Kim, Mihui; Yang, Yong Sook; Ko, Young–Guk; Choi, Mona

doi:10.3390/jcm11092547

Cited by 7 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, the numbers of patients who died in the hospital within 7 days and 30 days of a PAD diagnosis were 24 to 53 and 41 to 89, respectively, suggesting that a high proportion of in-hospital deaths occurred within 7 days. Patients with PAD may develop complications, such as ischemic myocardial and cerebrovascular events and sepsis [39][40][41], and older adults have a higher risk of complications than younger age groups [40]. Interventions and intensive monitoring of complications in the first month are necessary for hospitalized patients with PAD.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Prevalence of Peripheral Arterial Disease in South Korea: Retrospective Analysis of National Claims Data

Ryu¹,

Park²,

Kim³

et al. 2022

JMIR Public Health Surveill

Self Cite

View full text Add to dashboard Cite

Background Peripheral arterial disease (PAD) causes blood vessel narrowing that decreases blood flow to the lower extremities, with symptoms such as leg pain, discomfort, and intermittent claudication. PAD increases risks for amputation, poor health-related quality of life, and mortality. It is estimated that more than 200 million people worldwide have PAD, although the paucity of PAD research in the East detracts from knowledge on global PAD epidemiology. There are few national data–based analyses or health care utilization investigations. Thus, a national data analysis of PAD incidence and prevalence would provide baseline data to enable health promotion strategies for patients with PAD. Objective This study aims to identify South Korean trends in the incidence and prevalence of PAD and PAD treatment, in-hospital deaths, and health care utilization. Methods This was a retrospective analysis of South Korean national claims data from 2009 to 2018. The incidence of PAD was determined by setting the years 2010 and 2011 as a washout period to exclude previously diagnosed patients with PAD. The study included adults aged ≥20 and <90 years who received a primary diagnosis of PAD between 2011 and 2018; patients were stratified according to age, sex, and insurance status for the incidence and prevalence analyses. Descriptive statistics were used to assess incidence, prevalence, endovascular revascularization (EVR) events, amputations, in-hospital deaths, and the health care utilization characteristics of patients with PAD. Results Based on data from 2011 to 2018, there were an average of 124,682 and 993,048 incident and prevalent PAD cases, respectively, in 2018. PAD incidence (per 1000 persons) ranged from 2.68 to 3.09 during the study period. From 2012 to 2018, the incidence rate in both sexes showed an increasing trend. PAD incidence continued to increase with age. PAD prevalence (per 1000 persons) increased steadily, from 3.93 in 2011 to 23.55 in 2018. The number of EVR events varied between 933 and 1422 during the study period, and both major and minor amputations showed a decreasing trend. Health care utilization characteristics showed that women visited clinics more frequently than men, whereas men used tertiary and general hospitals more often than women. Conclusions The number of incident and prevalent PAD cases generally showed an increasing trend. Visits to tertiary and general hospitals were higher among men than women. These results indicate the need for attention not only to Western and male patients, but also to Eastern and female patients with PAD. The results are generalizable, as they are based on national claims data from the entire South Korean population, and they can promote preventive care and management strategies for patients with PAD in clinical and public health settings.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence and Prevalence of Peripheral Arterial Disease in South Korea: Retrospective Analysis of National Claims Data

Ryu¹,

Park²,

Kim³

et al. 2022

JMIR Public Health Surveill

Self Cite

View full text Add to dashboard Cite

show abstract

“…Purposeful sampling was used to recruit participants from the cardiovascular outpatient clinic of a tertiary hospital in Seoul, South Korea. A prior retrospective study that used electronic medical records from this hospital included 1,263 patients with PAD and the age range was 19-96 years (mean age 67.3 years; Kim et al, 2022b). Therefore, we tried to recruit as broad an age range as possible to explore the various experiences of the participants.…”

Section: Step 1: Analysis Of the Target Behaviormentioning

confidence: 99%

Development of an Ecological Momentary Assessment-Triggered Text Message Library for Peripheral Artery Disease

Kim

Choi

2023

West J Nurs Res

Self Cite

View full text Add to dashboard Cite

This study developed an ecological momentary assessment (EMA)-triggered text message library based on the behavior change wheel framework to encourage exercise engagement in patients with peripheral artery disease (PAD). This study was conducted in three steps. In Step 1, semi-structured interviews were conducted with 15 patients with PAD. Their accounts of their exercise experiences revealed six barriers and three facilitators through thematic analysis. In Step 2, based on the findings from the prior step, the EMA survey was developed; its items included barriers to exercise, PAD-related leg symptoms, and general conditions. In Step 3, intervention functions to overcome exercise barriers were mapped, and 120 text messages were generated. Responses to the exercise barriers in the EMA survey triggered the automatic text messages. Additional studies are needed to examine the end-user acceptability of the text message library and the effectiveness of EMA-triggered text message interventions.

show abstract

“…8,9 There is a need to investigate potential adverse event mechanisms, as many patients are affected by adverse events with unexplained mechanisms worldwide. [10][11][12] There are limited in vivo studies that investigate the effects of TKIs on different protein expressions or the activation of certain genes. Most of the in vivo studies focus on tumor response to the TKIs.…”

Section: Introductionmentioning

confidence: 99%

“… 8 , 9 There is a need to investigate potential adverse event mechanisms, as many patients are affected by adverse events with unexplained mechanisms worldwide. 10 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

In vitro PK/PD modeling of tyrosine kinase inhibitors in non‐small cell lung cancer cell lines

Wanika,

Evans,

Johnson

et al. 2024

Clinical Translational Sci

View full text Add to dashboard Cite

Tyrosine kinase inhibitors (TKIs) are routinely prescribed for the treatment of non‐small cell lung cancer (NSCLC). As with all medications, patients can experience adverse events due to TKIs. Unfortunately, the relationship between many TKIs and the occurrence of certain adverse events remains unclear. There are limited in vivo studies which focus on TKIs and their effects on different regulation pathways. Many in vitro studies, however, that investigate the effects of TKIs observe additional changes, such as changes in gene activations or protein expressions. These studies could potentially help to gain greater understanding of the mechanisms for TKI induced adverse events. However, in order to utilize these pathways in a pharmacokinetic/pharmacodynamic (PK/PD) framework, an in vitro PK/PD model needs to be developed, in order to characterize the effects of TKIs in NSCLC cell lines. Through the use of ordinary differential equations, cell viability data and nonlinear mixed effects modeling, an in vitro TKI PK/PD model was developed with estimated PK and PD parameter values for the TKIs alectinib, crizotinib, erlotinib, and gefitinib. The relative standard errors for the population parameters are all less than 25%. The inclusion of random effects enabled the model to predict individual parameter values which provided a closer fit to the observed response. It is hoped that this model can be extended to include in vitro data of certain pathways that may potentially be linked with adverse events and provide a better understanding of TKI‐induced adverse events.

show abstract

Major Adverse Events in Patients with Peripheral Artery Disease after Endovascular Revascularization: A Retrospective Study

Cited by 7 publications

References 29 publications

Incidence and Prevalence of Peripheral Arterial Disease in South Korea: Retrospective Analysis of National Claims Data

Incidence and Prevalence of Peripheral Arterial Disease in South Korea: Retrospective Analysis of National Claims Data

Development of an Ecological Momentary Assessment-Triggered Text Message Library for Peripheral Artery Disease

In vitro PK/PD modeling of tyrosine kinase inhibitors in non‐small cell lung cancer cell lines

Contact Info

Product

Resources

About