Major depression in coronary artery disease patients with vs. without a prior history of depression.

Freedland, Kenneth E.; Carney, Robert M.; Lustman, Patrick J.; Rich, Mike; Jaffe, Allan S.

doi:10.1097/00006842-199207000-00004

Cited by 66 publications

(33 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results arise from direct visualization of the coronary vessels and support findings from one previous study which has shown more severe CAD in the incident depression subtype although only at trend level (Freedland, 1992). Even though the sample size in the present study was modest, the prevalence of the two depression types is comparable to that in other studies (Grace et al, 2005;de Jonge et al, 2006).…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

Goodman

Shimbo

Haas

et al. 2008

Journal of Psychiatric Research

View full text Add to dashboard Cite

There is recent evidence that acute coronary syndrome (ACS) patients with first time incident major depressive disorder (MDD) and those with recurrent MDD represent different subtypes among individuals with ACS and comorbid depression. However, few studies have examined whether or not these subtypes differ in coronary artery disease (CAD) severity. We assessed whether those with incident MDD (in-hospital MDD and negative for history of MDD) or recurrent MDD (in-hospital MDD and a positive history of MDD) differ in angiographically documented CAD severity. Within 1 week of admission for ACS, 88 patients completed a clinical interview to assess current and past diagnosis of MDD. CAD severity was assessed in all patients by coronary angiography. A hierarchical regression analysis showed that neither in-hospital MDD status, nor history of MDD were significant predictors of CAD severity, but the interaction term between in-hospital MDD status and history of MDD was a significant predictor of CAD severity, after controlling for age, sex and ethnicity. Follow-up analyses showed that patients with first-time, incident MDD had significantly more severe CAD compared to patients with recurrent MDD (p = 0.043). To conclude, our study adds to the growing evidence that patients with incident MDD should be considered as a clinically distinct subtype from those with recurrent MDD. Possible mechanisms for differing CAD severity by angiogram between these two subtypes are proposed and implications for prognosis and treatment are discussed. KeywordsAcute Coronary Syndrome; Coronary Artery Disease; Myocardial Infarction; Angiogram; Incident Major Depressive Disorder; Recurrent Major Depressive Disorder Extensive research has shown that comorbid major depressive disorder (MDD) after an acute coronary syndrome (ACS) event is an independent prognostic marker of increased morbidity and mortality (Barth et al., 2004;van Melle et al., 2004 Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. (Thombs et al., 2006), and of these MDD patients, 50% or more have had depression symptoms in the past. Recent evidence suggests that patients who experience depression after ACS for the first time (incident depression) may represent a clinically distinct subtype when compared with depressed ACS patients who have had depressive symptoms in the past (recurrent depression). NIH Public AccessThe literature indicates that the extent to which comorbid MDD after ACS impacts future medical prognosis might be dependent on whether patients experience incident or recurrent depression. However, the evidence is mixed ...

show abstract

Section: Discussionsupporting

confidence: 89%

“…In a sample of 39 recently diagnosed CAD patients who met criteria for MDD, those with a depression history had less severe CAD in comparison to those without a depression history (Freedland et al, 1992). CAD severity was assessed by direct visualization of coronary arteries via angiogram, recorded as the number of occluded coronary arteries (>50% stenosed).…”

mentioning

confidence: 99%

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

Goodman

Shimbo

Haas

et al. 2008

Journal of Psychiatric Research

View full text Add to dashboard Cite

show abstract

“…Freedland et al [38 ]reported prevalences of 44% for recurrent major depressive disorder in newly diagnosed patients with CHD. A recently published study by Bankier et al [39 ]examined the prevalence of psychiatric disorders assessed with a diagnostic psychiatric interview in stable CHD outpatients and reported a substantial proportion (15%) of patients with dysthymia.…”

Section: Discussionmentioning

confidence: 99%

Associations between Major Depression, Bipolar Disorders, Dysthymia and Cardiovascular Diseases in the General Adult Population

Baune¹,

Adrian²,

Arolt³

et al. 2006

Psychother Psychosom

View full text Add to dashboard Cite

Background: Cardiovascular diseases (CVD) and affective disorders are both very prevalent in the general population. However, it is unclear on a population level if the prevalence of different subtypes of affective disorders like unipolar major depression or dysthymia is different in individuals with specific CVDs. Methods: In 4,181 participants of the general population, lifetime prevalences for affective disorders were assessed through the Composite International Diagnostic Interview and cardiovascular diseases by self-report and subsequent physician-verified diagnosis. Multivariable logistic regression was used in the analysis. Results: Prevalences of unipolar depression, bipolar disorder and dysthymia were significantly higher in participants with coronary heart disease or stroke compared to those without these CVDs. Dysthymia had a stronger (OR = 2.03; 95% CI = 1.21–3.39) association with coronary heart disease than unipolar depression (OR = 1.58; 95% CI = 1.09–2.30) or any depression (OR = 1.92; 95% CI = 1.37–2.70). In contrast, unipolar depression (OR = 2.27; 95% CI = 1.29–3.99) showed a significant OR for the relation with stroke compared to dysthymia that reached no statistical significance. The commonly used category ‘any depression’ revealed higher odds (OR = 2.50; 95% CI = 1.46–4.28) for the relationship with stroke than unipolar depression or dysthymia, but lower odds than bipolar I disorder (OR = 5.71, 95% CI = 1.23–26.66). Conclusions: Classification into diagnostic subgroups of affective disorders is important for an improved clinical and pathophysiological understanding of their relationship with CVDs. Dysthymia, in particular, plays an important role regarding the relation of affective disorders and CVDs. Future research on biological models may elucidate the pathophysiological link between subtypes of affective disorders and CVDs.

show abstract

“…Depression is not only seen in patients after an acute cardiac event, but in between 17 and 23% of those with newly diagnosed or chronic disease (cf., Carney et al, 1987). In addition, it appears that for as many as 50%, the depression predates the initial diagnosis of CHD (Freedland, Carney, Lustman, Rich, & Jaffe, 1992). Fewer studies have been conducted with patients undergoing coronary bypass surgery (CABG); however, research has found clinically meaningful depression in close to 50% of patients awaiting CABG, and in over 50% of patients up to six months after CABG (White et al, 1995).…”

Section: Depression In Chd Prevalencementioning

confidence: 99%

Depression in chronic medical illness: The case of coronary heart disease

2001

View full text Add to dashboard Cite

Depression is an important predictor of morbidity and mortality in patients with coronary disease, particularly after myocardial infarction, independent of previous cardiac history or CAD severity. Depression also is associated with poor long-term psychosocial outcomes. The prevalence of major depression among post-MI patients is 15 to 20%, with an additional 27% reporting symptoms of minor depression. This article briefly reviews the literature on depression in patients with coronary disease, including previously published efforts to treat the disorder in this group. A case review then is provided, highlighting important aspects of treatment.

show abstract

Major depression in coronary artery disease patients with vs. without a prior history of depression.

Cited by 66 publications

References 14 publications

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

Incident and recurrent major depressive disorder and coronary artery disease severity in acute coronary syndrome patients

Associations between Major Depression, Bipolar Disorders, Dysthymia and Cardiovascular Diseases in the General Adult Population

Depression in chronic medical illness: The case of coronary heart disease

Contact Info

Product

Resources

About