Major depressive disorder in patients with type 2 diabetes mellitus: Prevalence and clinical characteristics

Huang, Chun-Jen; Hsieh, Hui‐Min; Tu, Hung-Pin; Jiang, He-Jiun; Wang, Pengwei; Lin, Ching‐Hua

doi:10.1016/j.jad.2017.09.044

Cited by 16 publications

(11 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast, in the present meta‐analysis, only people with major depressive disorder diagnosed according to operationalized diagnostic criteria were included, therefore, direct comparisons among studies should be made with caution. In the present study the higher prevalence of major depressive disorder found in people with Type 2 diabetes compared to the general population (odds ratio 1.73) is consistent with previous findings . The impact of long‐term treatment, medication‐induced side effects and the high costs associated with diabetes are likely risk factors for depression .…”

Section: Discussionsupporting

confidence: 92%

“…A study conducted in 23 European countries found that women had almost twice the prevalence of major depressive disorder compared with men [28], which could be related, in part, to the effects of hormones in women [29]. A nonsignificant gender difference trend was observed previously in people with Type 2 diabetes [24] as well as in the present study (24.0% in women and 15.8% in men). Obesity is a significant contributing factor to the pathogenesis of depression [30].…”

Section: Discussionsupporting

confidence: 58%

See 1 more Smart Citation

Prevalence of comorbid major depressive disorder in Type 2 diabetes: a meta‐analysis of comparative and epidemiological studies

Wang

Zong³

et al. 2019

Diabet. Med.

View full text Add to dashboard Cite

Aims To examine the average point prevalence of major depressive disorder in people with Type 2 diabetes and its associated factors in a comprehensive meta‐analysis. Methods Two researchers independently conducted a systematic literature search of PubMed, EMBASE, PsycINFO and Cochrane databases. Studies reporting the prevalence of major depressive disorder in people with Type 2 diabetes were identified and analysed using a random‐effects model. Results A total of 26 studies meeting the inclusion criteria were included in the study. The point prevalence of major depressive disorder was 14.5% (95% CI 7.9–25.3; I²=99.65). People with Type 2 diabetes were more likely to have major depressive disorder compared with the general population (odds ratio 1.73, 95% CI 1.38–2.16). Subgroup and meta‐regression analyses showed that study site, study type, diagnostic criteria and age significantly moderated the prevalence of major depressive disorder. Conclusions In this meta‐analysis, the average point prevalence of major depressive disorder in people with Type 2 diabetes was high. Routine screening and more effective interventions should be implemented for this population.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 58%

Prevalence of comorbid major depressive disorder in Type 2 diabetes: a meta‐analysis of comparative and epidemiological studies

Wang

Zong³

et al. 2019

Diabet. Med.

View full text Add to dashboard Cite

show abstract

“…The disease can inevitably affect the original life of patients, produce a variety of negative emotional experience and psychological pressure, and even can evolve into emotional and psychological disorders. [ 1 ] T2DM can increase the risk of both serious physical and mental health issues. Diabetes mellitus suffering (diabetes distress [DD]) refers to the suffering emotion caused by excessive anxiety in disease management, treatment approach, emotional burden, emotional support, and so on.…”

Section: Introductionmentioning

confidence: 99%

Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies

et al. 2020

View full text Add to dashboard Cite

This study aimed to investigate diabetes distress, happiness, and its associated factors of patients with type 2 diabetes mellitus (T2DM) treated by different therapies, and to analyze the related impact factors. A total of 1512 patients with T2DM were randomly selected from 18 tertiary hospitals in Hunan province from January 2016 to April 2016 who has been treated with oral antidiabetics monotherapy, insulin monotherapy, and combination therapy. Use the general information questionnaire, WHO-5 (the World Health Organization 5 well-being index) and PAID (the problem areas in diabetes scale) to collect the data. There are 846 (55.95%) patients that have serious emotional disorders, and the diabetes related distress in insulin treatment group was higher than that in combination treatment group ( P < .05). Happiness of T2DM patients in combination therapy was higher than oral antidiabetic drug monotherapy and insulin monotherapy ( P < .05). There was a negative correlation between diabetic suffering and happiness in patients with different treatments ( R ranged from –0.335 to –0.436, P < .001). Age and happiness experience could explain 14.8% of the variance. Acute and chronic complications, controlled blood glucose level, lifestyle, therapies, and school education can explain 18.3% variance. Under different therapies, the suffering and happiness of T2DM patients differed from each other. The suffering and happiness of T2DM were related to different therapies, age, complications, glycaemic control, lifestyle, school education, and so on.

show abstract

“…A relationship exists between depression in pregnancy and gestational diabetes mellitus (GDM), as depression in the first trimester of pregnancy has been shown to predict the development of GDM. 145 In the general population, depression and type 2 diabetes are comorbid conditions, 146 with higher prevalence observed in females; 147 however, there are conflicting reports on the directionality of the relationship between depression and GDM. 148,149 Regardless, the association between depression and GDM may be explained by a shared pro-inflammatory state that results in the inability to produce enough insulin, 150 and puts women at risk for adverse cardiovascular outcomes.…”

Section: Gestational Diabetes Mellitusmentioning

confidence: 99%

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Mattina

Lieshout

Steiner

2019

Therapeutic Advances in Cardiovascular Disease

View full text Add to dashboard Cite

Women are at increased risk for developing depression and cardiovascular disease (CVD) across the lifespan and their comorbidity is associated with adverse outcomes that contribute significantly to rates of morbidity and mortality in women worldwide. Immunesystem activity has been implicated in the etiology of both depression and CVD, but it is unclear how inflammation contributes to sex differences in this comorbidity. This narrative review provides an updated synthesis of research examining the association of inflammation with depression and CVD, and their comorbidity in women. Recent research provides evidence of pro-inflammatory states and sex differences associated with alterations in the hypothalamic-pituitary-adrenal axis, the renin-angiotensin-aldosterone system and the serotonin/kynurenine pathway, that likely contribute to the development of depression and CVD. Changes to inflammatory cytokines in relation to reproductive periods of hormonal fluctuation (i.e. the menstrual cycle, perinatal period and menopause) are highlighted and provide a greater understanding of the unique vulnerability women experience in developing both depressed mood and adverse cardiovascular events. Inflammatory biomarkers hold substantial promise when combined with a patient's reproductive and mental health history to aid in the prediction, identification and treatment of the women most at risk for CVD and depression. However, more research is needed to improve our understanding of the mechanisms underlying inflammation in relation to their comorbidity, and how these findings can be translated to improve women's health.

show abstract

Major depressive disorder in patients with type 2 diabetes mellitus: Prevalence and clinical characteristics

Cited by 16 publications

References 52 publications

Prevalence of comorbid major depressive disorder in Type 2 diabetes: a meta‐analysis of comparative and epidemiological studies

Prevalence of comorbid major depressive disorder in Type 2 diabetes: a meta‐analysis of comparative and epidemiological studies

Diabetes distress, happiness, and its associated factors among type 2 diabetes mellitus patients with different therapies

Inflammation, depression and cardiovascular disease in women: the role of the immune system across critical reproductive events

Contact Info

Product

Resources

About