Major distinctions in the antioxidant responses in liver and kidney of Cd2+-treated common carp (Cyprinus carpio)

Linking Oxidative Stress and Magnitude of Compensatory Responses with Life-Stage Specific Differences in Sensitivity of White Sturgeon (Acipenser transmontanus) to Copper or Cadmium

“…Similar to effects of exposure to Cu, exposure to Cd resulted in significant impacts on molecular and biochemical processes associated with metal sequestration and antioxidant responses in early life-stages of white sturgeon. This result is consistent with results of previous studies in which exposure of fish to waterborne Cd was associated with oxidative stress, including increases in concentrations of LPO. , In the present work, unlike Cu, exposure to 5 μg Cd/L led to 3.5-fold greater concentrations of LPO in the body of sturgeon at 48 dph, which was the most sensitive life-stage, but not at 15 or 139 dph. The weak or absence of LPO response in 15 dph fish exposed to Cu and Cd, respectively, may indicate that the pathways responsible for this response are still developing at that life stage.…”

Limited oxidative stress in common carp (Cyprinus carpio, L., 1758) exposed to a sublethal tertiary (Cu, Cd and Zn) metal mixture

“…These results are interesting knowing that several previous studies showed an induction of oxidative stress in diverse fish species exposed to higher concentrations of metals. In the liver, C. carpio showed elevated O2 -• levels when exposed to 10 mg/L Cd 2+ (Dugmonits et al, 2013), elevated MDA levels when exposed to 0.41-2.06 mg/L Cd or 2.5 μM Cd 2+ (Jia et al, 2011;Zhang et al, 2017) and increased lipid peroxidation in gills and liver when exposed to 0.01 mg/L mercury (García-Medina et al, 2017). Lipid peroxidation levels increased with metals in Channa punctatus exposed to heavy metals in canals (Javed et al, 2016), in Galaxias maculatus exposed to 2.5 and 10 μg/L Cd (McRae et al 2018) and in…”

“…Its populations can be threatened by severe metal contamination (Ahmad et al, 2015). This species has been well studied to assess among others the effects of metal pollution on bioaccumulation (Bervoets et al, 2009), apoptosis (Cols Vidal et al, 2008Gao et al, 2013b), energy status (De Boeck et al, 1995b;Kunwar et al, 2009), lipid metabolism (Meng et al, 2018), immune function (Zhang et al, 2017) or oxidative stress (Cortes-Diaz et al, 2017;Dugmonits et al, 2013;García-Medina et al, 2017). Our study is the first to examine the combined effects of Cu, Zn and Cd mixtures on C. carpio.…”

Impact of acute Cd2+ exposure on the antioxidant defence systems in the skin and red blood cells of common carp (Cyprinus carpio)

“…To date, we have identified and characterized a large number of genes coding for antioxidant molecules, such as heat shock proteins (hsps) (Ali et al 2003), mt-1 and mt-2 (Hermesz et al 2001), gpx4a and gpx4b (Hermesz and Ferencz 2009), cat, gpx1, gr, and gss (Dugmonits et al 2013), and ho-1 and ho-2 (Jancso and Hermesz 2014) in one of the most important cultured fish species, the common carp (Cyprinus carpio). Our previous studies focused on the liver and kidney, the organs most involved in the processing and excretion of toxic agents.…”