Major royal jelly protein 2 acts as an antimicrobial agent and antioxidant in royal jelly

Park, Min Ji; Kim, Bo Yeon; Park, Hee Geun; Deng, Yulin; Yoon, Hyung Joo; Choi, Yong Soo; Lee, Kwang-Sik; Jin, Byung Rae

doi:10.1016/j.aspen.2019.05.003

Cited by 47 publications

(35 citation statements)

References 43 publications

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“…Moreover, the RJ organization can effectively decrease heat stress-induced reproductive damages through improvement of sperm attributes and MDA concentration restoration, proposing that RJ is a promising component to protect the reproduction in heat stress issue (Mahdivand et al, 2019). This bit of leeway is maybe a direct result of the presence of MRJPs in the RJ (Park et al, 2019). These properties supported the use of RJ as a well-known dietary enhancement and various pharmaceuticals related to fertility issue in animals (Maghsoudlou et al, 2019).…”

Section: Introductionmentioning

confidence: 89%

Effect of Gibberellic Acid and Royal Jelly Injection on Some Productive, Reproductive and Physiological Traits in Matrouh Chickens Strain During Summer Season.

Ezzat¹,

Rizk²,

Mohamed³

et al. 2020

Journal of Productivity and Development

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A total of 168 laying hens and 21 cocks of Matrouh local strain at 24 weeks of age (At 43.93 % egg production)was used in a completely randomized design among seven treatment groups with three replicates per treatment group (8 hens and 1 cock per replicate).Birds are biweekly injected, up to 36 weeks of age (12 weeks). The 1 st treatment group of birds were injected with saline solution 0.9% only and served as control, The birds in 2 nd and 3 rd treatment groups, were injected subcutaneously with 100 and 200 μg Gibberellic acid (GA3)/kg body weight (BW), respectively. The 4 th and 5 th treatment groups were injected with50 and 100 μg Royal Jelly (RJ)/kg BW, respectively. The 6 th treatment group was injected subcutaneously with 50μg GA3 plus25μg RJ/kg BW. The 7 th treatment group was injected subcutaneously with 100 μg GA3 plus 50μg RJ/kg BW. The same 7 treatment groups were used also, on 21 cocks in individual batteries to take semen quality. The obtained results revealed that, Injection with 100 , 200 μg GA3 or50 , 100 μg RJ /kg BW of Matrouh chicks improved significantly (P<0.05 and P<0.01) body weight changes (BWC),fertility eggs %, hatchability/total eggs % and chicks hatch weight (g), sperm-cell concentration (X 10 9 /ml) and sperm motility (%), while significantly (P<0.05) decreased each of dead spermatozoa (%), sperm abnormalities (%), and acrosomal damage (%) as compared with the control group. Layers injected by 100 , 200 μgGA3/kg body weight showed significantly (P≤0. 05 and P≤0. 01) improved feed conversion ratio (FCR), egg production (EP)% and egg mass (EM) compared with those the groups 170 EZZAT et al. 50 , 100 μg RJ /kg BW and control groups through the whole of the experimental period. Injection with 50, 100 μg of RJ /kg BW caused to increase significantly (P≤0. 01) in IgG and IgM and primary and secondary antibody titer against sheep red blood cells (SRBC's) in hens as compared with100, 200 μg of GA3and the control group. Injection 100 , 200 μg of GA3 /kg BW caused to increase significantly (P≤0. 05 and P≤0. 01) in concentration of estrogen in hens and testosterone of cocks, FSH and LH in hens and cocks when compared with those in control group. In conclusion, injection with 100, 200 μg GA3 /kg BW improved productive, reproductive and physiological performance of males and females Matrouh. Furthermore, the RJ-treated groups had significantly improved immune responses in hens and the quality of semen parameters in cocks under summer season conditions in Egypt.

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Section: Introductionmentioning

confidence: 89%

Effect of Gibberellic Acid and Royal Jelly Injection on Some Productive, Reproductive and Physiological Traits in Matrouh Chickens Strain During Summer Season.

Ezzat¹,

Rizk²,

Mohamed³

et al. 2020

Journal of Productivity and Development

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“…In summary, this substantial enhancement in the motility of frozen-thawed sperm may be due to the collective influences of the chemical composition of the amino acids and the noteworthy antioxidant capacity of the RJ (Bărnuţiu et al, 2011). Furthermore, RJ is rich in calcium ions that promote sperm motility by limiting the capacity of sperm cells (Howe, Dimick, & Benton, 1985;Kodai et al, 2007 (Asadi et al, 2019;Park et al, 2019). Likewise, Khadr et al (2015) pointed out that oral administration of 200 mg RJ/kg every other day for 6 weeks produced higher progressive motility percentage (91.0 ± 0.9) in pre-pubertal buck rabbits compared with the control group (70.0 ± 1.1).…”

Section: Sperm Motility Parametersmentioning

confidence: 98%

“…RJ is considered one of the widely applied natural supplement products. RJ is representing a fragment of principal food source diet for honey bee larvae and having a main role in caste recognition of this species (Maghsoudlou, Mahoonak, Mohebodini, & Toldra, 2019), by dint of having unique types of proteins and phytochemicals, and is rich in secondary metabolite (Park et al, 2019;Zhang et al, 2019).…”

Section: His Toric Al Vie Wmentioning

confidence: 99%

Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals

Abdelnour

El‐Hack

Alagawany

et al. 2020

Animal Physiology Nutrition

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Royal jelly (RJ) is one of the furthermost valuable curative products mentioned by natural medicine scientists due to its promising medical and nutritional purposes. It possesses many impacts, including antioxidants, antimicrobial, antitumor, antiinflammatory and immunomodulatory functions in human and animal that benefit How to cite this article: Abdelnour SA, Abd El-Hack ME, Alagawany M, et al. Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals.

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“…MRJPs 2 and 4 act as antimicrobial agents and have a wide range of activity against bacteria (Gram-positive and Gram-negative), fungi, and yeasts. Recombinant MRJP-2 and MRJP-4 could kill microorganisms by attaching to the cell wall of fungi, yeast, and bacteria that damage the structure of the cell wall [66,68]. RJ aqueous fraction has reported a strong inhibition of the growth of Fusarium species [73].…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…Moreover, ERJ has the potential as an oxidative agent to be used for human, as well as animal, diets [123]. Similarly, MRJP-2 has potential action as an antioxidant to protect mammalian and insect cells via decreasing the levels of caspase-3 activity and oxidative stress-induced cell apoptosis followed by increase cell viability [68]. Hydroxyl radicals and hydrogen-peroxide scavenging activity were verified with 29 antioxidant peptides isolated from RJ hydrolysate, in which 12 small peptides having 2-4 residues (Ala-Lys, Phe-Arg, Ile-Arg, Lys-Phe, Lys-Leu, Lys-Tyr, Arg-Tyr, Tyr-Asp, Tyr-Tyr, Leu-Asn-Arg, and Lys-Asn-Tyr-Pro) having the strongest activity.…”

Section: Antioxidant Activitymentioning

confidence: 99%

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

Ahmad

Campos

Fratini

et al. 2020

IJMS

169

134

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Royal jelly (RJ) is a yellowish-white and acidic secretion of hypopharyngeal and mandibular glands of nurse bees used to feed young worker larvae during the first three days and the entire life of queen bees. RJ is one of the most appreciated and valued natural product which has been mainly used in traditional medicines, health foods, and cosmetics for a long time in different parts of the world. It is also the most studied bee product, aimed at unravelling its bioactivities, such as antimicrobial, antioxidant, anti-aging, immunomodulatory, and general tonic action against laboratory animals, microbial organisms, farm animals, and clinical trials. It is commonly used to supplement various diseases, including cancer, diabetes, cardiovascular, and Alzheimer’s disease. Here, we highlight the recent research advances on the main bioactive compounds of RJ, such as proteins, peptides, fatty acids, and phenolics, for a comprehensive understanding of the biochemistry, biological, and pharmaceutical responses to human health promotion and life benefits. This is potentially important to gain novel insight into the biological and pharmaceutical properties of RJ.

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Major royal jelly protein 2 acts as an antimicrobial agent and antioxidant in royal jelly

Cited by 47 publications

References 43 publications

Effect of Gibberellic Acid and Royal Jelly Injection on Some Productive, Reproductive and Physiological Traits in Matrouh Chickens Strain During Summer Season.

Effect of Gibberellic Acid and Royal Jelly Injection on Some Productive, Reproductive and Physiological Traits in Matrouh Chickens Strain During Summer Season.

Useful impacts of royal jelly on reproductive sides, fertility rate and sperm traits of animals

New Insights into the Biological and Pharmaceutical Properties of Royal Jelly

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