Major secretory product of the mesometrial decidua in the rat, a variant of alpha-2-macroglobulin, binds insulin-like growth factor I via a protease-dependent mechanism

Correia-da-Silva, Georgina; Teixeira, Natércia; Bell, Steven

doi:10.1002/(sici)1098-2795(199605)44:1<103::aid-mrd12>3.0.co;2-5

Cited by 12 publications

(2 citation statements)

References 38 publications

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“…Plasma a 2 M accounts for 3% to 5% of total proteins and is primarily synthesized in the liver (95), while small amounts of this protein are synthesized by microglia as well (96). They act as modulators of acute phase response (97) and bind to and moderate the function of cytokines (97,98), a variety of growth factors (99) and potent proteases (100). Cytokines that bind to a 2 M include PDGF, TGFß1 and 2, bFGF, EGF and VEGF and interleukins (IL-1B, IL-6, IL-TGFß8).…”

Section: Pdgf Peptide and Their Receptorsmentioning

confidence: 99%

Growth factors in the fetal and neonatal lung

Kumar

Ryan²

2004

Front Biosci

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Formation and orderly development of the mammalian lung results from a complex set of cell to cell and cell to matrix interactions following transcriptional regulation during pulmonary organogenesis. Transcriptional control of differentiation genes early on and epithelial-mesenchymal interactions mediated by growth factors later on, resulting in the formation of conducting airways and an extensive alveolar capillary interface, is critical for normal lung development. HNF-3beta and TTF-1 are transcription factors that are involved in gene regulation and formation and differentiation of respiratory epithelium. Studies done in early mouse embryonic lung demonstrate that a variety of peptide growth factors and their receptors are expressed early on in lung development. Signalling through the FGFR2 is critical to normal development of the distal epithelium and mesenchyme. The inductive and permissive influences of growth factors on lung development has been demonstrated by gain or loss of function experiments in early embryonic mouse lung organ culture, in transgenic and in null mutant mice. VEGF present in airway epithelial cells is involved in the maturation as well as proliferation of capillary endothelial cells. Epithelial-endothelial interactions during lung development are important in establishing a functional blood gas interface. Epithelial-mesenchymal interactions mediated by growth factors are also important in the restoration of normal alveolar architecture after lung injury. Further understanding of the role of these growth factors and their cellular interactions in bronchopulmonary dysplasia and in tissue repair following lung injury, may lead to development of better therapeutic modalities in treating these disorders.

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Section: Pdgf Peptide and Their Receptorsmentioning

confidence: 99%

Growth factors in the fetal and neonatal lung

Kumar

Ryan²

2004

Front Biosci

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“…This differentiation process involves intense modifications in gene expression, cellular morphology and function. This process is also accompanied by secretion of various cytokines and hormones, being α2-macroglobulin (α2-MG), a protease inhibitor involved in the regulation of placental trophoblast invasion, the major product secreted by rat decidual tissue (da Silva et al, 1996;Gellersen et al, 2007). Besides α2-MG expression, an increase in alkaline phosphatase (ALP) activity in the uterine stroma is associated with the decidual cell reaction, characteristic of an increased metabolic activity (Christie, 1966).…”

Section: Introductionmentioning

confidence: 99%

Anandamide restricts uterine stromal differentiation and is critical for complete decidualization

Fonseca

Correia-da-Silva

Teixeira

2015

Molecular and Cellular Endocrinology

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Expression of mRNA encoding insulin-like growth factors I and II by uterine tissues and placenta during pregnancy in the rat

Correia-da-Silva

Bell

Teixeira³

1999

Mol. Reprod. Dev.

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The uterus and the placenta synthesize insulin‐like growth factors (IGFs) and insulin‐like binding proteins (IGFBPs). These growth factors are implicated in processes of proliferation and differentiation that occur in the uterus. To determine the patterns of expression of IGFs during rat pregnancy we used in situ hybridization with digoxigenin labeled probes on uterus from day 7 to day 16 of pregnancy. In early gestation days (7–8) both IGF mRNAs showed similar tissue distribution with relative abundance in the stroma and circular muscle layer. On days 11 and 12 expression for IGF‐I mRNA was found in the mesometrial decidua and metrial gland and in the ectoplacental cone while clear expression of IGF‐II mRNA could only be found in the latter. On days 13 and 14, expression for IGF‐I mRNA could be detected in the mesometrial decidua and metrial gland but no expression was observed for IGF‐II mRNA. A gradient of IGF‐I mRNA expression could be observed in the placenta on day 16, with the trophoblastic cells of the basal zone expressing the signal with stronger intensity than in the labyrinthine zone. For IGF‐II mRNA the highest expression was associated with the labyrinthine zone. Endovascular trophoblast was positive for both mRNAs. The spatial and temporal patterns of expression suggests a role for IGFs in the process of decidualization as well as in the establishment, growth and differentiation of the various trophoblast cells of the placenta. Mol. Reprod. Dev. 53:294–305, 1999. © 1999 Wiley‐Liss, Inc.

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Major secretory product of the mesometrial decidua in the rat, a variant of alpha-2-macroglobulin, binds insulin-like growth factor I via a protease-dependent mechanism

Cited by 12 publications

References 38 publications

Growth factors in the fetal and neonatal lung

Growth factors in the fetal and neonatal lung

Anandamide restricts uterine stromal differentiation and is critical for complete decidualization

Expression of mRNA encoding insulin-like growth factors I and II by uterine tissues and placenta during pregnancy in the rat

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