Major surgery in classic hemophilia using fraction I

Major surgery in haemophilia. Prolonged substitution therapy for surgical treatment of haemophilic cyst and pathological fracture of the femur

“…When replacement therapy was stopped on the seventy-third day, there was an exponential fall of plasma fibrinogen with a half-life of 6 days (Fig. 6), a value similar to that observed by Marder and Shulman (1966). The high fibrinogen concentration was associated with marked rouleaux formation on the blood-films and raised sedimentation rate, but no other side-effects were noted.…”

“…Haemolysis has been reported (McMillan and others, 1961; Newcomb and Watson, 1963) and may be due to red-cell iso-antibodies contaminating the H.A.H.G. (Marder and Shulman, 1966). Possibly more sophisticated methods of producing A.H.G.…”